Staging of argyrophilic grains: an age-associated tauopathy.

abstract：:A retrospective analysis of 14 patients who presented with a progressively expanding mass lesion(s) shown at biopsy/autopsy to represent acute demyelination was carried out. The aims of this study were to determine the optimal neuropathological approach to diagnosis and to determine the clinical evolution of this cond...

journal_title：Journal of neuropathology and experimental neurology

authors： Annesley-Williams D,Farrell MA,Staunton H,Brett FM

更新日期：2000-06-01 00:00:00

abstract：:The aim of our study is to evaluate the extent and distribution of grey matter demyelinating lesions in multiple sclerosis (MS), addressing also neuronal loss and synaptic loss. Whole coronal sections of 6 MS brains and 6 control brains were selected. Immunohistochemistry was performed for myelin basic protein, neurof...

journal_title：Journal of neuropathology and experimental neurology

authors： Vercellino M,Plano F,Votta B,Mutani R,Giordana MT,Cavalla P

更新日期：2005-12-01 00:00:00

abstract：:Genome-wide association studies have established BIN1 (Bridging Integrator 1) as the most significant late-onset Alzheimer disease (AD) susceptibility locus after APOE We analyzed BIN1 protein expression using automated immunohistochemistry on the hippocampal CA1 region in 19 patients with either no, mild, or moderate...

journal_title：Journal of neuropathology and experimental neurology

authors： Adams SL,Tilton K,Kozubek JA,Seshadri S,Delalle I

更新日期：2016-08-01 00:00:00

abstract：:Some agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma) belonging to the thiazolidinedione (TZD) family, as well as the cyclopentenone prostaglandin 15-dPGJ2, have been shown to cause neuroprotection in animal models of stroke. We have tested whether the TZD-unrelated PPARgamma agonist L-796,...

journal_title：Journal of neuropathology and experimental neurology

authors： Pereira MP,Hurtado O,Cárdenas A,Alonso-Escolano D,Boscá L,Vivancos J,Nombela F,Leza JC,Lorenzo P,Lizasoain I,Moro MA

更新日期：2005-09-01 00:00:00

abstract：:Retinoblastoma protein (pRb) is a ubiquitous 928-amino acid cell cycle regulatory molecule with diverse biologic activities. One critical function of pRb is the control of the G1-to-S phase checkpoint of the cell cycle. In the hypophosphorylated state, pRb suppresses the activity of E2F transcription factors thereby i...

journal_title：Journal of neuropathology and experimental neurology

authors： Stone JG,Siedlak SL,Tabaton M,Hirano A,Castellani RJ,Santocanale C,Perry G,Smith MA,Zhu X,Lee HG

更新日期：2011-07-01 00:00:00

abstract：:Nijmegen breakage syndrome caused by NBS1 germline mutations is a rare autosomal recessive disease with clinical features that include microcephaly, increased radiosensitivity, and predisposition to cancer. NBS1 plays a key role in DNA double-strand break repair and the maintenance of genomic stability. We screened 87...

journal_title：Journal of neuropathology and experimental neurology

authors： Watanabe T,Nobusawa S,Lu S,Huang J,Mittelbronn M,Ohgaki H

更新日期：2009-02-01 00:00:00

abstract：:In multiple sclerosis, remyelination becomes limited after repeated or prolonged episodes of demyelination. To test the effect of platelet-derived growth factor-A (PDGF-A) in recovery from chronic demyelination we induced corpus callosum demyelination using cuprizone treatment in hPDGF-A transgenic (tg) mice with the ...

journal_title：Journal of neuropathology and experimental neurology

authors： Vana AC,Flint NC,Harwood NE,Le TQ,Fruttiger M,Armstrong RC

更新日期：2007-11-01 00:00:00

abstract：:Cerebellar ataxia is a prominent clinical symptom in patients with mitochondrial DNA (mtDNA) disease. This is often progressive with onset in young adulthood. We performed a detailed neuropathologic investigation of the olivary-cerebellum in 14 genetically and clinically well-defined patients with mtDNA disease. Quant...

journal_title：Journal of neuropathology and experimental neurology

authors： Lax NZ,Hepplewhite PD,Reeve AK,Nesbitt V,McFarland R,Jaros E,Taylor RW,Turnbull DM

更新日期：2012-02-01 00:00:00

abstract：:The favorable response of oligodendrogliomas correlates well with characteristic chromosomal losses, of which loss of the short arm of chromosome 1 is most predictive. Oligodendrogliomas are histopathologically heterogeneous tumors and, in addition to the classic honeycomb histology, fields of nonclassic histology are...

journal_title：Journal of neuropathology and experimental neurology

authors： Kros JM,van der Weiden M,Zheng PP,Hop WC,van den Bent MJ,Kouwenhoven MC

更新日期：2007-12-01 00:00:00

abstract：:Since first described, amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of Guam has represented an important model of age-related neurodegenerative disease. ALS/PDC is characterized neuropathologically by severe widespread involvement by neurofibrillary tangles (NFTs). Over the past 30 years there...

journal_title：Journal of neuropathology and experimental neurology

authors： Perl DP,Hof PR,Purohit DP,Loerzel AJ,Kakulas BA

更新日期：2003-04-01 00:00:00

abstract：:The brainstem and cervical spinal cord were sampled from 45 cases of sudden infant death syndrome (SIDS), from 17 control cases without neurological disease, and from three negative control cases with abnormal growth of the central nervous system (36-98 postconceptional weeks). Morphometric analyses were performed on ...

journal_title：Journal of neuropathology and experimental neurology

authors： O'Kusky JR,Kozuki DE,Norman MG

更新日期：1995-07-01 00:00:00

abstract：:Central nervous system (CNS) tissue was studied by immunocytochemistry and electron microscopy from three cases of multiple sclerosis (MS) in which evidence of ongoing myelin breakdown could be documented. The study focussed upon the role of glial cells in the pathogenesis of demyelination. In acute MS, demyelination ...

journal_title：Journal of neuropathology and experimental neurology

authors： Lee SC,Moore GR,Golenwsky G,Raine CS

更新日期：1990-03-01 00:00:00

abstract：:Ca2+ currents are thought to enhance glutamate excitotoxicity. To investigate whether reduced expression of the Ca2+ limiting GluR2(B) subunit enhances seizure-induced vulnerability to either CA1 or CA3 neurons, we delivered GluR2(B) oligodeoxynucleotides (AS-ODNs) to the dorsal hippocampus of adult rats before induci...

journal_title：Journal of neuropathology and experimental neurology

authors： Friedman LK,Velísková J,Kaur J,Magrys BW,Liu H

更新日期：2003-07-01 00:00:00

abstract：:Tissue microarrays (TMAs), also known as "tissue chips," are a recently developed method that allows small cores or discs of tissue from dozens or hundreds of (usually paraffin-embedded) specimens to be re-embedded in a tissue block, which can then be further sectioned. The tissue cores can subsequently be studied usi...

journal_title：Journal of neuropathology and experimental neurology

authors： Goldstine J,Seligson DB,Beizai P,Miyata H,Vinters HV

更新日期：2002-08-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a neurodegenerative disorder that predominantly affects motor-related neuroanatomic structures. The role of microglia in MSA is unknown. To address this issue, we conducted quantitative image studies on the brains from 13 cases of MSA, comprising 8 cerebellar and 5 parkinsonian variant...

journal_title：Journal of neuropathology and experimental neurology

authors： Ishizawa K,Komori T,Sasaki S,Arai N,Mizutani T,Hirose T

更新日期：2004-01-01 00:00:00

abstract：:Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a nonhypertensive hereditary cerebral small vessel disease that is caused by mutations in a single gene, HTRA1. The HTRA1 protein normally represses transforming growth factor-β (TGF-β) signaling and its mutations ...

journal_title：Journal of neuropathology and experimental neurology

authors： Ito S,Takao M,Fukutake T,Hatsuta H,Funabe S,Ito N,Shimoe Y,Niki T,Nakano I,Fukayama M,Murayama S

更新日期：2016-11-01 00:00:00

abstract：:In 63 patients with malabsorption syndromes, 16 with congenital biliary atresia (BA) and 47 with cystic fibrosis (CF), axonal dystrophy in the gracile nucleus (ADG) was studied. Of the 16 patients with BA, ADG of considerable severity was observed in all 10 over one year of age. Of the 47 patients with CF, it was obse...

journal_title：Journal of neuropathology and experimental neurology

authors： Sung JH,Park SH,Mastri AR,Warwick WJ

更新日期：1980-09-01 00:00:00

abstract：:During brain development and blood-brain barrier (BBB) differentiation the expression of P-glycoprotein (P-gp) may complement the protective function of the placental barrier against xenobiotic substances. To establish an immunohistochemical procedure for P-gp detection, different anti-P-gp monoclonal antibodies were ...

journal_title：Journal of neuropathology and experimental neurology

authors： Virgintino D,Errede M,Girolamo F,Capobianco C,Robertson D,Vimercati A,Serio G,Di Benedetto A,Yonekawa Y,Frei K,Roncali L

更新日期：2008-01-01 00:00:00

abstract：:In an earlier study we found that a substantial percentage of mice surviving infection with canine distemper virus (CDV) slowly developed a morbid obesity syndrome. In the present study we wished to explore the role of the virus in the development of this syndrome. The distribution of viral antigen(s) in brains of pre...

journal_title：Journal of neuropathology and experimental neurology

authors： Nagashima K,Zabriskie JB,Lyons MJ

更新日期：1992-01-01 00:00:00

abstract：:Lysosomal storage disorders constitute a large group of genetic diseases, many of which are characterized by mental retardation and other neurologic symptoms. The mechanisms of neural dysfunction remain poorly understood. Because neural progenitor cells (NPCs) are fundamentally important to normal brain development an...

journal_title：Journal of neuropathology and experimental neurology

authors： Walton RM,Wolfe JH

更新日期：2007-08-01 00:00:00

abstract：:This is the fourth recorded patient with extension of syringomyelia into the brain rostral to the mesencephalon verified at autopsy. A syrinx was demonstrated from the low thoracic segments of the spinal cord to the cervico-medullary junction, where a fibrovascular malformation and dural-arachnoid adhesions deformed t...

journal_title：Journal of neuropathology and experimental neurology

authors： Berry RG,Chambers RA,Lublin FD

更新日期：1981-11-01 00:00:00

abstract：:A working group supported by the Office of Rare Diseases of the National Institutes of Health formulated neuropathologic criteria for corticobasal degeneration (CBD) that were subsequently validated by an independent group of neuropathologists. The criteria do not require a specific clinical phenotype, since CBD can h...

journal_title：Journal of neuropathology and experimental neurology

authors： Dickson DW,Bergeron C,Chin SS,Duyckaerts C,Horoupian D,Ikeda K,Jellinger K,Lantos PL,Lippa CF,Mirra SS,Tabaton M,Vonsattel JP,Wakabayashi K,Litvan I,Office of Rare Diseases of the National Institutes of Health.

更新日期：2002-11-01 00:00:00

abstract：:Morphologic investigations of the human visual pathways have been limited by the infeasibility of modern neuroanatomical approaches. Although contemporary methods for tracing axon pathways (such as tracer injections and electrophysiology) have elucidated the visual system in experimental animals, these techniques cann...

journal_title：Journal of neuropathology and experimental neurology

authors： Sadun AA,Smith LE,Kenyon KR

更新日期：1983-03-01 00:00:00

abstract：:Glial lipopigment appears in the globus pallidus without accumulating in neurons (except for late adolescence) in multiple chronic childhood diseases. In this observational study, we compared the age-related development of glial pigmentation in children with the chronic illness (cystic fibrosis) and children dying acu...

journal_title：Journal of neuropathology and experimental neurology

authors： Gilles FH,Tavaré CJ

更新日期：2002-04-01 00:00:00

abstract：:Remyelination capacity decreases with age in adult mice, but data comparing remyelination capacity after toxic demyelination in developing mice versus adult mice are not available. We treated 3-week-old and adult C57BL/6 mice with cuprizone for 1 to 5 weeks and studied demyelination/remyelination and cellular reaction...

journal_title：Journal of neuropathology and experimental neurology

authors： Pfeifenbring S,Nessler S,Wegner C,Stadelmann C,Brück W

更新日期：2015-08-01 00:00:00

abstract：:The concept of the presence of mucopolysaccharides forming an interstitial ground substance in central nervous tissues is revived. The biochemical reports of both neutral and acid mucopolysaccharides in both gray and white matter of the normal brain are reviewed. The earlier histochemical reports and the histochemical...

journal_title：Journal of neuropathology and experimental neurology

authors： Feigin I

更新日期：1980-01-01 00:00:00

abstract：:We describe the clinical, pathological, ultrastructural and biochemical features in the case of a 15-year-old boy with multiple sulfatase deficiency. Clinical abnormalities included hypotonia, retarded psychomotor development, hepatosplenomegaly, pigmentary degeneration of the retina, myoclonic seizures, aortic insuff...

journal_title：Journal of neuropathology and experimental neurology

authors： Guerra WF,Verity MA,Fluharty AL,Nguyen HT,Philippart M

更新日期：1990-07-01 00:00:00

abstract：:To understand the basis of oligodendrocyte (OL) susceptibility to oxidative injury, purified rat OL cultures at different stages of maturation were exposed to nitric oxide (NO) donors with fast or slow kinetics of release and to tert-butyl-hydroperoxide, a membrane-permeant organic hydroperoxide. OL precursors (pre-OL...

journal_title：Journal of neuropathology and experimental neurology

authors： Bernardo A,Greco A,Levi G,Minghetti L

更新日期：2003-05-01 00:00:00

abstract：:Neurofilamentous axonal swellings occur in a number of degenerative and toxic disorders of the nervous system. In one of these, experimental intoxication with beta, beta'-iminodiproprionitrile (IDPN), accumulation of neurofilaments has been shown to result from a defect in slow axonal transport. The consequence of thi...

journal_title：Journal of neuropathology and experimental neurology

authors： Clark AW,Griffin JW,Price DL

更新日期：1980-01-01 00:00:00

abstract：:Chorea-Acanthocytosis (CHAC) is an autosomal recessive disease characterized by neurodegeneration and acanthocytosis. Enhanced creatine kinase concentration is a constant feature of the condition. The mechanism underlying CHAC is unknown. However, acanthocytosis and enhanced creatine kinase suggest a protein defect th...

journal_title：Journal of neuropathology and experimental neurology

authors： Melone MA,Di Fede G,Peluso G,Lus G,Di Iorio G,Sampaolo S,Capasso A,Gentile V,Cotrufo R

更新日期：2002-10-01 00:00:00