Abstract：
:Glial lipopigment appears in the globus pallidus without accumulating in neurons (except for late adolescence) in multiple chronic childhood diseases. In this observational study, we compared the age-related development of glial pigmentation in children with the chronic illness (cystic fibrosis) and children dying acutely. A secondary goal was to search for pallidal neuronal lipopigment in childhood. We recorded pigmentation in the brains of 37 consecutive cystic fibrosis children ranging in age from 0-23 yr and in 17 controls ranging in age from 0-18 yr. We characterized the lipofuscin histochemically and used several regression models to describe the mode of deposition. We observed that in the controls, intraglial pallidal pigment accumulated in 2 forms (relatively large globules and, separately, as clusters of fine granules) at a slow rate during childhood. In cystic fibrosis, both forms of pallidal glial pigment started accumulating at a younger age and were deposited far more rapidly. There was a further increase in the rate of accumulation between 8 and 10 yr of age. We did not encounter pallidal neuronal lipofuscin at any age. These observations are consistent with 2 propositions: 1) that globus pallidus glial cells are unique in their ability to accumulate lipofuscin before it accumulates in nearby neurons; and 2) that they are particularly susceptible to some systemic effect of this chronic illness.
journal_name
J Neuropathol Exp Neuroljournal_title
Journal of neuropathology and experimental neurologyauthors
Gilles FH,Tavaré CJdoi
10.1093/jnen/61.4.351subject
Has Abstractpub_date
2002-04-01 00:00:00pages
351-7issue
4eissn
0022-3069issn
1554-6578journal_volume
61pub_type
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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更新日期：1983-03-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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doi：10.1097/00005072-199307000-00009
更新日期：1993-07-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
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doi：10.1097/NEN.0b013e3181a2afa0
更新日期：2009-05-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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更新日期：2019-01-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
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更新日期：2001-06-01 00:00:00
abstract：:The 2016 WHO classification of brain tumors represents a major step towards the integration of molecular data into pathologic diagnoses. Our institution has included massively parallel sequencing technology in the diagnostic work-up of all gliomas since January 2016. The utilized platform successfully identifies copy ...
journal_title：Journal of neuropathology and experimental neurology
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更新日期：2019-03-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198409000-00008
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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更新日期：2005-06-01 00:00:00
abstract：:TAR DNA-binding protein 43 (TDP-43) is a major component of the inclusions in frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U). We studied TDP-43 pathology in the hippocampus and frontal cortex of autopsy brains from patients with FTLD-U (n = 68), dementia lacking distinctive histopathology (n ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章,多中心研究
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