A novel concept of glomeruloid body formation in experimental cerebral metastases.

abstract：:Defects in synaptic development and plasticity may lead to autism. Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptogenesis and synaptic plasticity. BDNF is synthesized as a precursor, pro-BDNF, which can be processed into either a truncated form or into mature BDNF. Previous studies reported i...

journal_title：Journal of neuropathology and experimental neurology

authors： Garcia KL,Yu G,Nicolini C,Michalski B,Garzon DJ,Chiu VS,Tongiorgi E,Szatmari P,Fahnestock M

更新日期：2012-04-01 00:00:00

abstract：:Smooth muscle cells cultured from leptomeningeal vessels from old dogs with amyloid-angiopathy accumulate intracellular deposits that are immunoreactive for amyloid-beta peptide (A beta). We used this cellular model in the present study to examine the influence of sera and cerebrospinal fluid on intracellular accumula...

journal_title：Journal of neuropathology and experimental neurology

authors： Mazur-Kolecka B,Frackowiak J,Carroll RT,Wisniewski HM

更新日期：1997-03-01 00:00:00

abstract：:Purified myelin from the peripheral nervous system of guinea pig, frog (Rana catesbeiana), rat, rabbit, beef, and human in Freund's adjuvant were injected into the Lewis rat. Groups of rats receiving injections of myelin from different species were examined for signs of dysfunction and lesions in the PNS and CNS. Inje...

journal_title：Journal of neuropathology and experimental neurology

authors： Smith ME,Forno LS,Hofmann WW

更新日期：1979-07-01 00:00:00

abstract：:Calpain, a calcium-activated neutral protease family, has been implicated in the neuropathologic sequelae accompanying various neurological disorders. We have characterized the distribution and time course of calpain activation following brain injury in the rat, using a monoclonal antibody that recognizes calpain-gene...

journal_title：Journal of neuropathology and experimental neurology

authors： Saatman KE,Bozyczko-Coyne D,Marcy V,Siman R,McIntosh TK

更新日期：1996-07-01 00:00:00

abstract：:The interaction of phosphatidylserine (PS), exposed on the surface of apoptotic cells and with its specific receptor (PtdSerR) expressed by microglia, is a crucial event in the recognition and clearance of apoptotic neurons. Here, we extend our previous studies in which PS-liposomes mimicking apoptotic cells were used...

journal_title：Journal of neuropathology and experimental neurology

authors： De Simone R,Ajmone-Cat MA,Tirassa P,Minghetti L

更新日期：2003-02-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) have the potential to improve functional recovery in patients with spinal cord injury (SCI); however, they are limited by low survival rates after transplantation in the injured tissue. Our objective was to clarify the effects of a temporal blockade of interleukin 6 (IL-6)/IL-6 recept...

journal_title：Journal of neuropathology and experimental neurology

authors： Tan Y,Uchida K,Nakajima H,Guerrero AR,Watanabe S,Hirai T,Takeura N,Liu SY,Johnson WE,Baba H

更新日期：2013-10-01 00:00:00

abstract：:The present study introduces an in vitro model of xenogeneic peripheral nerve rejection to analyze the role of macrophages in this complex immunological situation. Nerve-sensitized mouse peritoneal exudate cells were co-cultured with rat peripheral nerve segments. The cultured rat nerve segments were fulminantly rejec...

journal_title：Journal of neuropathology and experimental neurology

authors： Brück W,Brück Y,Maruschak B,Friede RL

更新日期：1994-01-01 00:00:00

abstract：:During the Zika epidemic in Brazil, a baby was born at term with microcephaly and arthrogryposis. The mother had Zika symptoms at 10 weeks of gestation. At 17 weeks, ultrasound showed cerebral malformation and ventriculomegaly. At 24 weeks, the amniotic fluid contained ZIKV RNA and at birth, placenta and maternal bloo...

journal_title：Journal of neuropathology and experimental neurology

authors： Chimelli L,Moura Pone S,Avvad-Portari E,Farias Meira Vasconcelos Z,Araújo Zin A,Prado Cunha D,Raposo Thompson N,Lopes Moreira ME,Wiley CA,da Silva Pone MV

更新日期：2018-03-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) occurs most often in immunosuppressed individuals. The lesions of PML result from astrocyte and oligodendrocyte infection by the polyomavirus JC (JCV); JCV has also been shown to infect and destroy cerebellar granule cell neurons (GCNs) in 2 human immunodeficiency virus...

journal_title：Journal of neuropathology and experimental neurology

authors： Wüthrich C,Cheng YM,Joseph JT,Kesari S,Beckwith C,Stopa E,Bell JE,Koralnik IJ

更新日期：2009-01-01 00:00:00

abstract：:Tissue hypoxia and necrosis represent pathophysiologic and histologic hallmarks of glioblastoma (GBM). Although hypoxia inducible factor 1α (HIF-1α) plays crucial roles in the malignant phenotypes of GBM, developing HIF-1α-targeted agents has been hampered by the lack of a suitable preclinical model that recapitulates...

journal_title：Journal of neuropathology and experimental neurology

authors： Nigim F,Cavanaugh J,Patel AP,Curry WT Jr,Esaki S,Kasper EM,Chi AS,Louis DN,Martuza RL,Rabkin SD,Wakimoto H

更新日期：2015-07-01 00:00:00

abstract：:The long-term disabilities associated with spinal cord injury (SCI) are primarily due to the absence of robust neuronal regeneration and functional plasticity. The inability of the axon to regenerate after SCI is contributed by several intrinsic factors that trigger a cascade of molecular growth program and modulates ...

journal_title：Journal of neuropathology and experimental neurology

authors： Bhowmick S,Abdul-Muneer PM

更新日期：2021-01-20 00:00:00

abstract：:This study examines a radiation-induced invasion and spread of Schwann cells into ventral gray regions of the lumbar spinal cord. The prevalence of these cells within the gray matter and the time course of their appearance in the ventral spinal cord is quite different from the pattern of Schwann cell development in do...

journal_title：Journal of neuropathology and experimental neurology

authors： Sims TJ,Durgun MB,Gilmore SA

更新日期：1998-09-01 00:00:00

abstract：:The phenotypic identities and characterization of neural networks disrupted after neonatal hypoxia-ischemia (HI) in the preterm brain remain to be elucidated. Interruption of the central serotonergic (5-hydroxytryptamine [5-HT]) system can lead to numerous functional deficits, many of which match those in human preter...

journal_title：Journal of neuropathology and experimental neurology

authors： Wixey JA,Reinebrant HE,Buller KM

更新日期：2011-01-01 00:00:00

abstract：:Lhermitte-Duclos disease (LDD) is a rare cerebellar tumor associated with Cowden disease (CD) and germline mutations in the PTEN gene. To further define these relationships, we reviewed clinical and pathologic findings in 31 LDD cases and analyzed the status of the PTEN pathway in 11 of them. We hypothesized that the ...

journal_title：Journal of neuropathology and experimental neurology

authors： Abel TW,Baker SJ,Fraser MM,Tihan T,Nelson JS,Yachnis AT,Bouffard JP,Mena H,Burger PC,Eberhart CG

更新日期：2005-04-01 00:00:00

abstract：:Rupture of a saccular intracranial aneurysm (sIA) is often fatal. Thus, early detection of rupture-prone sIAs is vital. Myeloperoxidase (MPO), derived mainly from neutrophils, associates with sIA rupture, and therefore its role in sIA pathogenesis warrants further studies. We analyzed MPO and its association with othe...

journal_title：Journal of neuropathology and experimental neurology

authors： Ollikainen E,Tulamo R,Lehti S,Hernesniemi J,Niemelä M,Kovanen PT,Frösen J

更新日期：2018-06-01 00:00:00

abstract：:How to assess the substantial neuronal loss in a neurodegenerative disease such as Alzheimer disease is still being debated. Recently, stereological procedures have been proposed that claim improved accuracy and statistical power, but the results of some of these investigations have been controversial. In this study w...

journal_title：Journal of neuropathology and experimental neurology

authors： Everall IP,DeTeresa R,Terry R,Masliah E

更新日期：1997-11-01 00:00:00

abstract：:An experimental neuropathy in rats produced by tying loosely constrictive ligatures around one sciatic nerve has recently been shown to produce pain-related behavior that follows a reproducible time course. In the present study, we assessed the degree of thermal hyperesthesia and examined the sciatic nerves by light a...

journal_title：Journal of neuropathology and experimental neurology

authors： Sommer C,Galbraith JA,Heckman HM,Myers RR

更新日期：1993-05-01 00:00:00

abstract：:Retinal vasculopathy with cerebral leukodystrophy (RVCL) is an autosomal-dominant disorder involving the cerebral, retinal, renal, and other systemic microvessels due to frameshift mutations in the TREX1 gene. Under physiological conditions, the TREX1 protein is localized in the cellular cytoplasm and perinuclear area...

journal_title：Journal of neuropathology and experimental neurology

authors： Saito R,Nozaki H,Kato T,Toyoshima Y,Tanaka H,Tsubata Y,Morioka T,Horikawa Y,Oyanagi K,Morita T,Onodera O,Kakita A

更新日期：2019-02-01 00:00:00

abstract：:Remyelination capacity decreases with age in adult mice, but data comparing remyelination capacity after toxic demyelination in developing mice versus adult mice are not available. We treated 3-week-old and adult C57BL/6 mice with cuprizone for 1 to 5 weeks and studied demyelination/remyelination and cellular reaction...

journal_title：Journal of neuropathology and experimental neurology

authors： Pfeifenbring S,Nessler S,Wegner C,Stadelmann C,Brück W

更新日期：2015-08-01 00:00:00

abstract：:Gliomas with hybrid oligodendroglial/astrocytic features are diagnostically problematic, and our ability to predict tumor behavior is limited. Some likely represent intermingled mixed oligoastrocytomas (MOAs), though precise diagnostic criteria and specific markers for this lesion are lacking. From the files at Washin...

journal_title：Journal of neuropathology and experimental neurology

authors： Fuller CE,Schmidt RE,Roth KA,Burger PC,Scheithauer BW,Banerjee R,Trinkaus K,Lytle R,Perry A

更新日期：2003-11-01 00:00:00

abstract：:The tau deposits found in neurodegenerative diseases are classified based on their isoforms, that is, 3-repeat (3R) tau and 4-repeat (4R) tau. These isoforms are distinguishable using the antibodies RD3 and RD4, respectively, and Gallyas (Gal) and Campbell-Switzer (CS) silver staining methods, respectively. Tau is als...

journal_title：Journal of neuropathology and experimental neurology

authors： Ichihara K,Uchihara T,Nakamura A,Suzuki Y,Mizutani T

更新日期：2009-09-01 00:00:00

abstract：:In a series of 126 meningiomas, tumor and patient characteristics were investigated and statistically analyzed. A combined cytogenetic and molecular genetic approach was used to study chromosomal abnormalities and loss of markers on chromosome 22q. This approach was successfully applied to 93 meningiomas. In 66 cases,...

journal_title：Journal of neuropathology and experimental neurology

authors： Lekanne Deprez RH,Riegman PH,van Drunen E,Warringa UL,Groen NA,Stefanko SZ,Koper JW,Avezaat CJ,Mulder PG,Zwarthoff EC

更新日期：1995-03-01 00:00:00

abstract：:The content of RNA and volume of individual neurons isolated from the nucleus dorsalis and from the ventrolateral portion of the lumbar swelling were determined in eight cases of amyotrophic lateral sclerosis (ALS) and eight controls whose spinal cords were obtained at autopsy. The mean content of RNA in the lumbar mo...

journal_title：Journal of neuropathology and experimental neurology

authors： Davidson TJ,Hartmann HA

更新日期：1981-03-01 00:00:00

abstract：:Well myelinated cultures of newborn mouse cerebellum, exposed to varying concentrations of sodium diethyldithiocarbamate (DDC), a heavy metal chelating agent, were examined by light and electron microscopy. DDC treatment of cultures for 24-48 hours produced swellings of axons and presynaptic endings, the morphological...

journal_title：Journal of neuropathology and experimental neurology

authors： Kim SU,Rizzuto N

更新日期：1975-11-01 00:00:00

abstract：:The role of regenerating axons in the restructuring of the endoneurium into minifascicles after peripheral nerve injury was investigated. Endoneurial changes were studied in the control distal stumps of crushed rat sciatic nerves and in the distal nerve stumps in which, in addition to other cellular elements, the orig...

journal_title：Journal of neuropathology and experimental neurology

authors： Popović M,Bresjanac M,Sketelj J

更新日期：1994-11-01 00:00:00

abstract：:This study explores the biochemical basis that may distinguish neurologic and nonneurologic forms of Gaucher's disease. Crude membrane preparations from spleens of controls and patients representing the three clinical categories of Gaucher's disease were delipidated by extraction with sodium cholate and n-butanol. Tot...

journal_title：Journal of neuropathology and experimental neurology

authors： Glew RH,Daniels LB,Clark LS,Hoyer SW

更新日期：1982-11-01 00:00:00

abstract：:Normal human frontal lobe white matter obtained at autopsy was used to determine the extent of in situ post-mortem degradation of myelin basic protein (BP). Effects of the following two factors were studied: 1) time interval between death and autopsy, and 2) freezing and thawing the tissue. Quantitative extraction of...

journal_title：Journal of neuropathology and experimental neurology

authors： Ansari KA,Rand A,Hendrickson H,Bentley MD

更新日期：1976-03-01 00:00:00

abstract：:Cytologic evaluation of cerebrospinal fluid (CSF) is an effective means for diagnosing many disorders involving the central nervous system (CNS). Interpretation of these samples requires an understanding of the spectrum of neurologic diseases which involves the subarachnoid space, either primarily or secondarily, as w...

journal_title：Journal of neuropathology and experimental neurology

authors： Bigner SH

更新日期：1992-05-01 00:00:00

abstract：:Shigella dysenteriae strains produce an exotoxin (SdT) which inhibits protein synthesis in susceptible cells and is neurotoxic in some species. Intraneural microinjection of highly purified SdT into the cervical vagus nerves of rats, mice, guinea pigs and rabbits produced cytopathic changes within 24 hours in vagal se...

journal_title：Journal of neuropathology and experimental neurology

authors： Wiley RG,Donohue-Rolfe A,Keusch GT

更新日期：1985-09-01 00:00:00

abstract：:Lysosomal storage disorders constitute a large group of genetic diseases, many of which are characterized by mental retardation and other neurologic symptoms. The mechanisms of neural dysfunction remain poorly understood. Because neural progenitor cells (NPCs) are fundamentally important to normal brain development an...

journal_title：Journal of neuropathology and experimental neurology

authors： Walton RM,Wolfe JH

更新日期：2007-08-01 00:00:00