Abstract:
:Adult male rats were housed in a colony environment for six months, with ad lib access to anise-flavored 10% ethanol in water. Animals were then removed from the colony, and their consumption of alcohol during a period in isolated housing was measured. Individual rats were scored as high, moderate, and low consumers. Animals from each scoring category were killed for light and electron microscopic study of central nervous system tissue. High consumers frequently displayed varicose distortions of the dendritic profiles, with internal membranous vesicles. Such abnormalities were rarely found in dendrites of low-ethanol-consuming colony mates. The dendritic vacuoles often appeared empty and membrane-limited. Some vacuoles contained membranous inclusions. Dendrites which displayed electron-lucent cavities without membranous limits or contents were also found. Some invaginations of dendritic membranes were identified. The possible sequential relationship between these forms of dendritic alterations could not be determined. Some neuron cell bodies displayed vacuolar inclusions as well. Dendritic and somatic abnormalities were found in cerebral and cerebellar cortices, hippocampus, mammillary bodies, and the periaqueductal gray matter of the brain stem.
journal_name
J Neuropathol Exp Neuroljournal_title
Journal of neuropathology and experimental neurologyauthors
Goldstein B,Maxwell DS,Ellison G,Hammer RPdoi
10.1097/00005072-198309000-00009subject
Has Abstractpub_date
1983-09-01 00:00:00pages
579-89issue
5eissn
0022-3069issn
1554-6578journal_volume
42pub_type
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journal_title:Journal of neuropathology and experimental neurology
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