Brain oxidative stress induced by obstructive jaundice in rats.

abstract：:Chronic experimental allergic encephalomyelitis (EAE), produced in inbred guinea pigs given a single inoculation during the juvenile period with isologous spinal cord in complete Freund's adjuvant, has been studied by light and electron microscopy. Most animals showed a delayed onset of nurologic signs from 12 to 68 w...

journal_title：Journal of neuropathology and experimental neurology

authors： Snyder DH,Valsamis MP,Stone SH,Raine CS

更新日期：1975-05-01 00:00:00

abstract：:Mutations in dysferlin cause an inherited muscular dystrophy because of defective membrane repair. Three interacting partners of dysferlin are also implicated in membrane resealing: caveolin-3 (in limb girdle muscular dystrophy type 1C), annexin A1, and the newly identified protein mitsugumin 53 (MG53). Mitsugumin 53 ...

journal_title：Journal of neuropathology and experimental neurology

authors： Waddell LB,Lemckert FA,Zheng XF,Tran J,Evesson FJ,Hawkes JM,Lek A,Street NE,Lin P,Clarke NF,Landstrom AP,Ackerman MJ,Weisleder N,Ma J,North KN,Cooper ST

更新日期：2011-04-01 00:00:00

abstract：:We report a novel case of a World Health Organization grade 3 anaplastic meningioma arising from the olfactory groove in an 83-year-old woman. Molecular and methylation profiling confirm this lesion to be an NF2 subtype, methylation class intermediate type B meningioma. As most meningiomas in this location are indolen...

journal_title：Journal of neuropathology and experimental neurology

authors： Foo ASC,Tan DTM,Tan CL,Sahm F,von Deimling A,Yeo TT

更新日期：2017-12-01 00:00:00

abstract：:Localized hypertrophic neuropathy is a rare Schwann cell proliferation that usually affects single nerves from the extremities, and it is of unclear etiology in its pure form. RASopathies are a defined group of genetic diseases with overlapping clinical features, usually secondary to germline mutations in genes encodi...

journal_title：Journal of neuropathology and experimental neurology

authors： Vizcaino MA,Belzberg A,Ahlawat S,Belakhoua S,Chen L,Staedtke V,Rodriguez FJ

更新日期：2020-06-01 00:00:00

abstract：:Side population (SP) cells identified using the Hoechst 33342 fluorescent dye efflux technique overlap with the tumor stem cell fraction that is responsible for tumorigenesis and recurrence in malignant gliomas. Because diffuse invasion of glioma cells represents the main obstacle to successful therapy and underlies r...

journal_title：Journal of neuropathology and experimental neurology

authors： Weber K,Paulus W,Senner V

更新日期：2010-06-01 00:00:00

abstract：:The triplication of the DYRK1A gene encoding proline-directed serine/threonine kinase and located in the critical region of Down syndrome (DS) has been implicated in cognitive deficits and intellectual disability of individuals with DS. We investigated the effect of abnormal levels of this kinase on the cytoskeleton i...

journal_title：Journal of neuropathology and experimental neurology

authors： Dowjat K,Adayev T,Kaczmarski W,Wegiel J,Hwang YW

更新日期：2012-12-01 00:00:00

abstract：:Numerous studies have established the key role of the Golgi apparatus (GA) in post-translational processing, transport and targeting of proteins destined for secretion, lysosomes and plasma membranes. Moreover, several studies performed in our laboratories have shown that the size of the immunocytochemically detected ...

journal_title：Journal of neuropathology and experimental neurology

authors： Salehi A,Ravid R,Gonatas NK,Swaab DF

更新日期：1995-09-01 00:00:00

abstract：:The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immun...

journal_title：Journal of neuropathology and experimental neurology

authors： Del Tredici K,Rüb U,De Vos RA,Bohl JR,Braak H

更新日期：2002-05-01 00:00:00

abstract：:Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive function following cerebrovascular accidents. The purpose of this study was to profile gene expression changes unique to VaD to identify and characterize disease relevant ...

journal_title：Journal of neuropathology and experimental neurology

authors： McKay EC,Beck JS,Khoo SK,Dykema KJ,Cottingham SL,Winn ME,Paulson HL,Lieberman AP,Counts SE

更新日期：2019-05-01 00:00:00

abstract：:The microtubule-associated phosphoprotein, tau, is an integral component of paired helical filaments in Alzheimer neurofibrillary tangles (NFT). The mechanism of NFT formation is unknown but aberrant phosphorylation of tau may be contributory. Calcium/calmodulin-dependent protein kinase type II (CaM kinase II), the mo...

journal_title：Journal of neuropathology and experimental neurology

authors： McKee AC,Kosik KS,Kennedy MB,Kowall NW

更新日期：1990-01-01 00:00:00

abstract：:β-Amyloid (Aβ) plaques can trigger chronic inflammation in the cellular environment that recruits infiltrating macrophages during the course of Alzheimer disease (AD). Activated macrophages release pro-inflammatory cytokines that increase neurotoxicity associated with AD. A major impediment to investigating neuroinfla...

journal_title：Journal of neuropathology and experimental neurology

authors： Kozyrev N,Albers S,Yang J,Prado VF,Prado MAM,Fonseca GJ,Rylett RJ,Dekaban GA

更新日期：2020-11-01 00:00:00

abstract：:Axonal damage is the major cause of irreversible neurologic disability in patients with multiple sclerosis. Although axonal damage correlates with antibodies against neurofilament light (NF-L) protein, a major component of the axonal cytoskeleton, the possible pathogenic role of autoimmunity to axonal antigens such as...

journal_title：Journal of neuropathology and experimental neurology

authors： Huizinga R,Heijmans N,Schubert P,Gschmeissner S,'t Hart BA,Herrmann H,Amor S

更新日期：2007-04-01 00:00:00

abstract：:PROX1 is a prospero-related transcription factor that plays a critical role in the development of various organs including the mammalian lymphatic and central nervous systems; it controls cell proliferation and differentiation through different transcription pathwaysand has both oncogenic and tumor-suppressive functio...

journal_title：Journal of neuropathology and experimental neurology

authors： Elsir T,Eriksson A,Orrego A,Lindström MS,Nistér M

更新日期：2010-02-01 00:00:00

abstract：:The effects of hypoglycemia on cerebrovascular permeability to a protein, horseradish peroxidase (HRP), were studied in mice given 3 or 8 units of crytalline zinc insulin intraperitoneally. HRP (10 mg in 0.1 ml saline) was injected intravenously 15 to 20 minutes prior to sacrifice. Both mildly and severely hypoglycemi...

journal_title：Journal of neuropathology and experimental neurology

authors： Hsu DW,Hedley-Whyte ET

更新日期：1980-05-01 00:00:00

abstract：:Hereditary gelsolin amyloidosis (AGel amyloidosis) is a systemic disorder reported worldwide in kindreds with a G654A or G654T gelsolin gene mutation. The clinically characteristic peripheral nerve involvement has been poorly characterized morphologically, and its pathogenesis remains unknown. We studied peripheral ne...

journal_title：Journal of neuropathology and experimental neurology

authors： Kiuru-Enari S,Somer H,Seppäläinen AM,Notkola IL,Haltia M

更新日期：2002-06-01 00:00:00

abstract：:White matter hyperintensities (WMH) are prevalent. Although arteriolar disease has been implicated in their pathogenesis, venous pathology warrants consideration. We investigated relationships of WMH with histologic venous, arteriolar and white matter abnormalities and correlated findings with premortem neuroimaging. ...

journal_title：Journal of neuropathology and experimental neurology

authors： Keith J,Gao FQ,Noor R,Kiss A,Balasubramaniam G,Au K,Rogaeva E,Masellis M,Black SE

更新日期：2017-04-01 00:00:00

abstract：:The neurodegenerative synucleinopathies, which include Parkinson disease, multiple-system atrophy, and Lewy body disease, are characterized by the presence of abundant neuronal inclusions called Lewy bodies and Lewy neurites. These disorders remain incurable, and a greater understanding of the pathologic processes is ...

journal_title：Journal of neuropathology and experimental neurology

authors： Jones DR,Delenclos M,Baine AT,DeTure M,Murray ME,Dickson DW,McLean PJ

更新日期：2015-12-01 00:00:00

abstract：:Immunohistochemical identification of myelin basic protein (MBP) is a sensitive method for assessing myelination in the human fetal central nervous system (CNS). However, the temporospatial relationship of expression of two other major myelin proteins, proteolipid protein (PLP) and myelin-associated glycoprotein (MAG)...

journal_title：Journal of neuropathology and experimental neurology

authors： Weidenheim KM,Bodhireddy SR,Rashbaum WK,Lyman WD

更新日期：1996-06-01 00:00:00

abstract：:The aim of this study was to identify aberrantly expressed proteins in pediatric primitive neuroectodermal tumors (PNETs) and ependymomas. Tumor tissue of 29 PNET and 12 ependymoma patients was subjected to 2-dimensional difference gel electrophoresis. Gel analysis resulted in 79 protein spots being differentially exp...

journal_title：Journal of neuropathology and experimental neurology

authors： de Bont JM,den Boer ML,Kros JM,Passier MM,Reddingius RE,Smitt PA,Luider TM,Pieters R

更新日期：2007-06-01 00:00:00

abstract：:To develop improved therapies for medulloblastoma, we studied the ability of a neuroattenuated HSV-1 ICP34.5 mutant (variant-1716) to replicate within and destory an authentic medulloblastoma cell line known as Med 283 (D283) using immunohistochemistry, in situ hybridization, and viral titrations. In vitro studies sho...

journal_title：Journal of neuropathology and experimental neurology

authors： Lasner TM,Kesari S,Brown SM,Lee VM,Fraser NW,Trojanowski JQ

更新日期：1996-12-01 00:00:00

abstract：:Neurofibromatosis 2 (NF2), a dominantly inherited disorder, is typically manifested as bilateral vestibular Schwannomas and predisposes to other nervous system tumors. Vestibular Schwannomas also occur sporadically but the onset is usually at an older age. Surgical and histological studies have shown that vestibular S...

journal_title：Journal of neuropathology and experimental neurology

authors： Antinheimo J,Haapasalo H,Seppälä M,Sainio M,Carpen O,Jääskeläinen J

更新日期：1995-11-01 00:00:00

abstract：:Neurofilamentous axonal swellings occur in a number of degenerative and toxic disorders of the nervous system. In one of these, experimental intoxication with beta, beta'-iminodiproprionitrile (IDPN), accumulation of neurofilaments has been shown to result from a defect in slow axonal transport. The consequence of thi...

journal_title：Journal of neuropathology and experimental neurology

authors： Clark AW,Griffin JW,Price DL

更新日期：1980-01-01 00:00:00

abstract：:Histological examination by light and electron microscopy of the spinal cords of four dogs rapidly perfusion-fixed after the onset of decompression sickness revealed the presence of numerous non-staining, space-occupying lesions that were absent in similarly prepared sections of control or ischemic spinal cords. We pr...

journal_title：Journal of neuropathology and experimental neurology

authors： Francis TJ,Pezeshkpour GH,Dutka AJ,Hallenbeck JM,Flynn ET

更新日期：1988-07-01 00:00:00

abstract：:The role of axonal transport in the pathogenesis of the axonal swellings which develop at the severed ends of transected axons was studied by electron microscopic (EM) autoradiography. Proteins carried by fast anterograde transport in rat sciatic nerves were labeled with [3H]-leucine or [3H]-fucose; [3H]-leucine, [3H]...

journal_title：Journal of neuropathology and experimental neurology

authors： Griffin JW,Price DL,Engel WK,Drachman DB

更新日期：1977-03-01 00:00:00

abstract：:Cerebral accumulation of amyloid-beta (Abeta) is characteristic of Alzheimer disease and of amyloid precursor protein (APP) transgenic mice. Here, we assessed the efficacy of CI-1011, an inhibitor of acyl-coenzyme A:cholesterol acyltransferase, which is suitable for clinical use, in reducing amyloid pathology in both ...

journal_title：Journal of neuropathology and experimental neurology

authors： Huttunen HJ,Havas D,Peach C,Barren C,Duller S,Xia W,Frosch MP,Hutter-Paier B,Windisch M,Kovacs DM

更新日期：2010-08-01 00:00:00

abstract：:The interaction of phosphatidylserine (PS), exposed on the surface of apoptotic cells and with its specific receptor (PtdSerR) expressed by microglia, is a crucial event in the recognition and clearance of apoptotic neurons. Here, we extend our previous studies in which PS-liposomes mimicking apoptotic cells were used...

journal_title：Journal of neuropathology and experimental neurology

authors： De Simone R,Ajmone-Cat MA,Tirassa P,Minghetti L

更新日期：2003-02-01 00:00:00

abstract：:A direct causal relationship between a human DNA virus, adeno serotype 12, and malignant transformation in target cells (sensory retinal neuronal precursors) was suggested by the development of a remarkably uniform retinoblastoma-like neoplasm in rats. In order to focus upon incipient photoreceptor differentiation, 27...

journal_title：Journal of neuropathology and experimental neurology

authors： Mukai N,Murao T

更新日期：1975-01-01 00:00:00

abstract：:Essential tremor (ET) patients develop more cognitive impairment and dementia than controls, although there are surprisingly few data on the neuropathological basis for cognitive changes in ET. In this postmortem study, we assessed tau and other pathologies in 26 ET cases and 73 controls (non-ET) (1:3 matching). The m...

journal_title：Journal of neuropathology and experimental neurology

authors： Farrell K,Cosentino S,Iida MA,Chapman S,Bennett DA,Faust PL,Louis ED,Crary JF

更新日期：2019-01-01 00:00:00

abstract：:A number of studies have implicated a proline-directed protein kinase, glycogen synthase kinase-3 (GSK-3) in the hyperphosphorylation of tau in Alzheimer's disease (AD). Toward understanding the role of GSK-3 in the abnormal hyperphosphorylation of tau in AD we have found that GSK-3 is prominently present in neuronal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Pei JJ,Tanaka T,Tung YC,Braak E,Iqbal K,Grundke-Iqbal I

更新日期：1997-01-01 00:00:00

abstract：:Bcl-2, a cell death suppressor protein, is expressed during brain development but is largely down-regulated in the adult central nervous system. We previously reported strong expression of bcl-2 in small, "oligodendrocyte-like" cells (OLC) found in glioneuronal hamartias. These hamartias are microscopic cell rests fou...

journal_title：Journal of neuropathology and experimental neurology

authors： Yachnis AT,Roper SN,Love A,Fancey JT,Muir D

更新日期：2000-02-01 00:00:00