Clinicopathological Staging of Dynamics of Neurodegeneration and Neuronal Loss in Alzheimer Disease.

abstract：:The blood-brain barrier (BBB) is recognized as a barrier to the trafficking of molecules and cellular elements into the central nervous system (CNS). Horseradish peroxidase (HRP) exclusion is used as a measure of BBB integrity. The BBB is altered and becomes permeable during the course of experimental allergic encepha...

journal_title：Journal of neuropathology and experimental neurology

authors： Knobler RL,Marini JC,Goldowitz D,Lublin FD

更新日期：1992-01-01 00:00:00

abstract：:The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immun...

journal_title：Journal of neuropathology and experimental neurology

authors： Del Tredici K,Rüb U,De Vos RA,Bohl JR,Braak H

更新日期：2002-05-01 00:00:00

abstract：:Lewy body-like hyaline inclusions in the soma and swollen, cord-like cell processes are characteristic alterations of the anterior horn cells in familial amyotrophic lateral sclerosis (ALS) with posterior column and spinocerebellar tract involvement. A fine structural analysis of these two structures has been performe...

journal_title：Journal of neuropathology and experimental neurology

authors： Hirano A,Nakano I,Kurland LT,Mulder DW,Holley PW,Saccomanno G

更新日期：1984-09-01 00:00:00

abstract：:Remyelination capacity decreases with age in adult mice, but data comparing remyelination capacity after toxic demyelination in developing mice versus adult mice are not available. We treated 3-week-old and adult C57BL/6 mice with cuprizone for 1 to 5 weeks and studied demyelination/remyelination and cellular reaction...

journal_title：Journal of neuropathology and experimental neurology

authors： Pfeifenbring S,Nessler S,Wegner C,Stadelmann C,Brück W

更新日期：2015-08-01 00:00:00

abstract：:Alzheimer-type I astrogliopathy (AIA) is an uncommon neuropathological phenomenon encountered in Wilson's disease and less often in acquired hepatic encephalopathy. Since its first description in 1912 it has received little attention. However, after 1971, when the nature of its morphogenesis began to be recognized and...

journal_title：Journal of neuropathology and experimental neurology

authors： Ma KC

更新日期：2001-02-01 00:00:00

abstract：:In multiple sclerosis, remyelination becomes limited after repeated or prolonged episodes of demyelination. To test the effect of platelet-derived growth factor-A (PDGF-A) in recovery from chronic demyelination we induced corpus callosum demyelination using cuprizone treatment in hPDGF-A transgenic (tg) mice with the ...

journal_title：Journal of neuropathology and experimental neurology

authors： Vana AC,Flint NC,Harwood NE,Le TQ,Fruttiger M,Armstrong RC

更新日期：2007-11-01 00:00:00

abstract：:Cerebral cavernous malformations (CCMs) often cause hemorrhages that can result in severe clinical manifestations, including hemiparesis and seizures. The underlying mechanisms of the aggressive behavior of CCMs are undetermined to date, but alterations of vascular matrix components may be involved. We compared the lo...

journal_title：Journal of neuropathology and experimental neurology

authors： Schneider H,Errede M,Ulrich NH,Virgintino D,Frei K,Bertalanffy H

更新日期：2011-06-01 00:00:00

abstract：:The periaqueductal gray (PAG) plays a central role in the integration of defense responses to threatening or stressful stimuli. Little is known about the neurochemical development of the human PAG around the time of birth, when the fetus makes the transition to extrauterine life and independent defense responses are n...

journal_title：Journal of neuropathology and experimental neurology

authors： Reddy SC,Panigrahy A,White WF,Kinney HC

更新日期：1996-04-01 00:00:00

abstract：:We report a novel case of a World Health Organization grade 3 anaplastic meningioma arising from the olfactory groove in an 83-year-old woman. Molecular and methylation profiling confirm this lesion to be an NF2 subtype, methylation class intermediate type B meningioma. As most meningiomas in this location are indolen...

journal_title：Journal of neuropathology and experimental neurology

authors： Foo ASC,Tan DTM,Tan CL,Sahm F,von Deimling A,Yeo TT

更新日期：2017-12-01 00:00:00

abstract：:Fibrosis is the main cause of irreversible nerve damage in leprosy. Phenotypic changes in Mycobacterium leprae (ML)-infected Schwann cells (SCs) have been suggested to mediate this process. We found that SC line cultures stimulated with ML upregulated transforming growth factor-β1 (TGF-β1), and that TGF-β1 or ML induc...

journal_title：Journal of neuropathology and experimental neurology

authors： Petito RB,Amadeu TP,Pascarelli BM,Jardim MR,Vital RT,Antunes SL,Sarno EN

更新日期：2013-04-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder associated with repetitive traumatic brain injury. Multiple system atrophy (MSA) is a Parkinsonian disorder that can result in repetitive falls with associated head trauma. We hypothesized that patients with neurodegenerative disorders ...

journal_title：Journal of neuropathology and experimental neurology

authors： Koga S,Dickson DW,Bieniek KF

更新日期：2016-10-01 00:00:00

abstract：:We review the newest advances related to seeking the pathogenic mechanism(s) of sporadic inclusion-body myositis (s-IBM) and present the pathologic diagnostic criteria of s-IBM. We discuss the possible pathogenic role of several themes, such as 1) increased amyloid-beta precursor protein (AbetaPP) and of its fragment ...

journal_title：Journal of neuropathology and experimental neurology

authors： Askanas V,Engel WK

更新日期：2001-01-01 00:00:00

abstract：:The favorable response of oligodendrogliomas correlates well with characteristic chromosomal losses, of which loss of the short arm of chromosome 1 is most predictive. Oligodendrogliomas are histopathologically heterogeneous tumors and, in addition to the classic honeycomb histology, fields of nonclassic histology are...

journal_title：Journal of neuropathology and experimental neurology

authors： Kros JM,van der Weiden M,Zheng PP,Hop WC,van den Bent MJ,Kouwenhoven MC

更新日期：2007-12-01 00:00:00

abstract：:The kinin B1 receptor is an inducible receptor expressed in response to inflammatory mediators. We sought to determine whether kinin B1 receptor can be expressed on human brain endothelial cells (HBECs) in vitro and whether signaling via this receptor can regulate permeability and chemokine production properties of th...

journal_title：Journal of neuropathology and experimental neurology

authors： Prat A,Biernacki K,Pouly S,Nalbantoglu J,Couture R,Antel JP

更新日期：2000-10-01 00:00:00

abstract：:The oligoastrocytoma, as a mixed glioma, represents a nosologic dilemma with respect to precisely defining the oligodendroglial and astroglial phenotypes that constitute the neoplastic cell lineages of these tumors. In this study, cell image analysis with Feulgen-stained nuclei was used to distinguish between oligoden...

journal_title：Journal of neuropathology and experimental neurology

authors： Decaestecker C,Lopes BS,Gordower L,Camby I,Cras P,Martin JJ,Kiss R,VandenBerg SR,Salmon I

更新日期：1997-04-01 00:00:00

abstract：:The balance between excitatory and inhibitory synaptic inputs is critical for the physiological control of motoneurons. The maintenance of a low-intracellular chloride concentration by the potassium chloride cotransporter 2 (KCC2) is essential for the efficacy of fast synaptic inhibition of mature motoneurons in respo...

journal_title：Journal of neuropathology and experimental neurology

authors： Fuchs A,Ringer C,Bilkei-Gorzo A,Weihe E,Roeper J,Schütz B

更新日期：2010-10-01 00:00:00

abstract：:Brainstem Lewy bodies (LB) are neuronal inclusions that are closely related to Parkinson's disease (PD). The filamentous component of LB from patients with PD contains biochemically altered neurofilaments (NF). Herein we have tested the hypothesis that the oxidized products of catechols may covalently crosslink NF. Ne...

journal_title：Journal of neuropathology and experimental neurology

authors： Montine TJ,Farris DB,Graham DG

更新日期：1995-05-01 00:00:00

abstract：:There are phenotypic and functional differences between vascular endothelium from different tissues and between microvascular and macrovascular endothelial cells (ECs) from the same tissue. Relatively little is known about the human blood-nerve barrier (BNB). We report the development of an in vitro BNB model using pr...

journal_title：Journal of neuropathology and experimental neurology

authors： Yosef N,Xia RH,Ubogu EE

更新日期：2010-01-01 00:00:00

abstract：:Bcl-2, a cell death suppressor protein, is expressed during brain development but is largely down-regulated in the adult central nervous system. We previously reported strong expression of bcl-2 in small, "oligodendrocyte-like" cells (OLC) found in glioneuronal hamartias. These hamartias are microscopic cell rests fou...

journal_title：Journal of neuropathology and experimental neurology

authors： Yachnis AT,Roper SN,Love A,Fancey JT,Muir D

更新日期：2000-02-01 00:00:00

abstract：:Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable neurons of patients with Alzheimer disease (AD). To determine whether oxidative damage is an early- or end-stage event in the process of neurod...

journal_title：Journal of neuropathology and experimental neurology

authors： Nunomura A,Perry G,Aliev G,Hirai K,Takeda A,Balraj EK,Jones PK,Ghanbari H,Wataya T,Shimohama S,Chiba S,Atwood CS,Petersen RB,Smith MA

更新日期：2001-08-01 00:00:00

abstract：:Primary central nervous system lymphomas (PCNSLs) are more resistant to radiotherapy and chemotherapy in AIDS (A-PCNSLs) than in non-AIDS patients (NA-PCNSLs). We investigated 23 A-PCNSLs and 24 NA-PCNSLs. Lymphoma cell kinetics (i.e. proliferation [mitotic index, MIB-1 and PCNA labeling indices], apoptosis and turnov...

journal_title：Journal of neuropathology and experimental neurology

authors： Christov C,Adle-Biassette H,Lechapt E,Poron F,Gray F,Gaulard P,Gherardi RK

更新日期：1999-10-01 00:00:00

abstract：:During brain development and blood-brain barrier (BBB) differentiation the expression of P-glycoprotein (P-gp) may complement the protective function of the placental barrier against xenobiotic substances. To establish an immunohistochemical procedure for P-gp detection, different anti-P-gp monoclonal antibodies were ...

journal_title：Journal of neuropathology and experimental neurology

authors： Virgintino D,Errede M,Girolamo F,Capobianco C,Robertson D,Vimercati A,Serio G,Di Benedetto A,Yonekawa Y,Frei K,Roncali L

更新日期：2008-01-01 00:00:00

abstract：:Friedreich's Ataxia (FRDA) is caused by a homozygous intronic GAA expansion in the FXN gene. FRDA affects primarily the peripheral nervous system (PNS) with cumulative evidence from postmortem studies and in vitro models suggesting a developmental component of its pathology. In the present study, we aimed at gaining f...

journal_title：Journal of neuropathology and experimental neurology

authors： Indelicato E,Nachbauer W,Eigentler A,Rudzki D,Wanschitz J,Boesch S

更新日期：2018-12-01 00:00:00

abstract：:Defects in synaptic development and plasticity may lead to autism. Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptogenesis and synaptic plasticity. BDNF is synthesized as a precursor, pro-BDNF, which can be processed into either a truncated form or into mature BDNF. Previous studies reported i...

journal_title：Journal of neuropathology and experimental neurology

authors： Garcia KL,Yu G,Nicolini C,Michalski B,Garzon DJ,Chiu VS,Tongiorgi E,Szatmari P,Fahnestock M

更新日期：2012-04-01 00:00:00

abstract：:A noninvasive photodynamic method has been developed to produce focal brain necrosis using porphyrin activated in vivo with laser light. After peripheral injection of the photosensitive porphyrin derivative, Photofrin I, mice were irradiated on the posterior lateral aspect of the head through the intact depilated scal...

journal_title：Journal of neuropathology and experimental neurology

authors： Stroop WG,Battles EJ,Townsend JJ,Schaefer DC,Baringer JR,Straight RC

更新日期：1989-09-01 00:00:00

abstract：:Mouse central nervous system tissue cultured for different lengths of time was analyzed for the proliferation of macrophages. These cells were identified and characterized by ultrastructural features, cell surface determinants and their ability to ingest latex particles and bacteria. Under the experimental conditions ...

journal_title：Journal of neuropathology and experimental neurology

authors： Raedler E,Raedler A

更新日期：1984-09-01 00:00:00

abstract：:The light and electron microscopic features of an unique retroperitoneal ganglioneuroblastoma in a four-year-old female are described. The unprecedented concurrence of Hirano, zebra, membranous cytoplasmic (MCB), and Pick bodies in the same population of neoplastic, sympathetic ganglion cells provides further evidence...

journal_title：Journal of neuropathology and experimental neurology

authors： Powers JM,Balentine JD,Wiśniewski HM,Terry RD

更新日期：1976-01-01 00:00:00

abstract：:Alpha-synuclein (alpha-synuclein) lesions are characteristic of idiopathic Parkinson disease (PD) and other alpha-synucleinopathies. To study the frequency of alpha-synuclein lesions in normal aging and how frequently they coexist with lesions of Alzheimer disease (AD), we examined the autopsy brains from normal and d...

journal_title：Journal of neuropathology and experimental neurology

authors： Mikolaenko I,Pletnikova O,Kawas CH,O'Brien R,Resnick SM,Crain B,Troncoso JC

更新日期：2005-02-01 00:00:00

abstract：:This study determined if hippocampal AMPA and NMDA subunit immunoreactivity (IR) in temporal lobe epilepsy patients was increased compared with nonseizure autopsies. Hippocampi from hippocampal sclerosis patients (HS; n = 26) and nonsclerosis cases (non-HS: n = 12) were compared with autopsies (n = 6) and studied for ...

journal_title：Journal of neuropathology and experimental neurology

authors： Mathern GW,Pretorius JK,Mendoza D,Lozada A,Leite JP,Chimelli L,Fried I,Sakamoto AC,Assirati JA,Adelson PD

更新日期：1998-06-01 00:00:00

abstract：:Spirochetal infections are an important cause of neurological disease. In previous studies of the pathogenesis of spirochetal brain infection, mice inoculated with Borrelia turicatae, an agent of tick-borne relapsing fever in North America, developed mild meningitis and parenchymal activation/infiltration by interleuk...

journal_title：Journal of neuropathology and experimental neurology

authors： Londoño D,Carvajal J,Arguelles-Grande C,Marques A,Cadavid D

更新日期：2008-10-01 00:00:00