Abstract：
:The expression of preproenkephalin messenger RNA was studied in the brain of Parkinson disease (PD) patients using in situ hybridization. All these patients were treated with levodopa (LD) and the development of motor complications was recorded. Eleven normal controls and 14 PD patients were used, of which 4 developed dyskinesias, 3 developed wearing-off, 3 developed both dyskinesias and wearing-off, and 4 developed no adverse effect following dopaminomimetic therapy. Nigrostriatal denervation was similar between the subgroups of PD patients as assessed using 125I-RTI-specific binding to the dopamine transporter and measures of catecholamine concentrations by HPLC. A significant increase of preproenkephalin messenger RNA levels was observed in the lateral putamen of dyskinetic patients in comparison to controls (+210%; p < 0.01) and in comparison to nondyskinetic patients (+112%; p < 0.05). No change was observed in medial parts of the putamen or in the caudate nucleus. No relationship between preproenkephalin messenger RNA levels and other clinical variables such as development of wearing-off, age of death, duration of disease, or duration of LD therapy was found. These findings suggest that increase synthesis of preproenkephalin in the medium spiny output neurons of the striatopallidal pathway play a role in the development of dyskinesias following long-term LD therapy in Parkinson disease.
journal_name
J Neuropathol Exp Neuroljournal_title
Journal of neuropathology and experimental neurologyauthors
Calon F,Birdi S,Rajput AH,Hornykiewicz O,Bédard PJ,Di Paolo Tdoi
10.1093/jnen/61.2.186subject
Has Abstractpub_date
2002-02-01 00:00:00pages
186-96issue
2eissn
0022-3069issn
1554-6578journal_volume
61pub_type
杂志文章abstract：:Herpes simplex virus type 1 (HSV-1) is the cause of a serious and often fatal encephalitis. Patients who survive herpes simplex encephalitis (HSE) experience behavioral abnormalities including profound cognitive dysfunctions. We have developed a rat model of acute HSE to investigate the cognitive impairments caused by...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199305000-00008
更新日期：1993-05-01 00:00:00
abstract：:The medulla was sampled from nine cases of sudden infant death syndrome (SIDS) and from six age-matched control cases without neurological disease. Morphometric analyses were performed on serial Nissl sections through the hypoglossal nucleus on the left side of the medulla. The total volume of the nucleus and both the...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199509000-00003
更新日期：1995-09-01 00:00:00
abstract：:Inclusion body myositis (IBM) is a late-onset inflammatory myopathy with distinctive clinical and histopathological features. The molecular basis for the disease remains unknown, but abnormal nuclear morphology and the accumulation of a protein that binds single-stranded DNA in a sequence-independent fashion suggest a...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199805000-00003
更新日期：1998-05-01 00:00:00
abstract：:Glioblastoma (GBM), representing WHO grade IV astrocytoma, is a relatively common primary brain tumor in adults with an exceptionally dismal prognosis. With an incidence rate of over 10 000 cases in the United States annually, the median survival rate ranges from 10-15 months in IDH1/2-wildtype tumors and 24-31 months...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlz025
更新日期：2019-06-01 00:00:00
abstract：:An A and L system of neutral amino acid transport has been demonstrated previously in cerebral microvessels in vivo and in isolated microvessels in vitro. This report describes the neutral amino acid transport properties of cultured cerebral endothelial cells and investigates the influence of astroglia on the transpor...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198303000-00008
更新日期：1983-03-01 00:00:00
abstract：:In an effort to develop a method of tissue injury which would provide a model for the study of axonal regrowth in adult mammalian central nervous system (CNS), we have analyzed the effects of freezing in the dorsal columns of more than 200 rat spinal cords. The effects of temperature and time of exposure upon the size...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198611000-00009
更新日期：1986-11-01 00:00:00
abstract：:Hypoxia administered after transient global cerebral ischemia (tGCI) has been shown to induce neuroprotection in adult rats, but the underlying mechanisms for this protection are unclear. Here, we tested the hypothesis that hypoxic postconditioning (HPC) induces neuroprotection through upregulation of hypoxia-inducibl...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0000000000000118
更新日期：2014-10-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198311000-00004
更新日期：1983-11-01 00:00:00
abstract：:Neoplastic transformation is often associated with aberrant gap junctional intercellular communication. We assessed mutations and expression of the connexin43 (Cx43) gene in 49 intracranial meningiomas. SSCP analyses followed by direct DNA sequencing showed GCG-->GTG (Ala-->Val) transition mutation in codon 253 of the...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:We have encountered a series of 8 third ventricular neoplasms with a distinctive chordoid appearance that appear to represent a clinicopathologic entity. The tumors occurred in 7 females and 1 male, ranging in age from 31 to 70 years. In all cases, imaging studies showed a large well-circumscribed third ventricular ma...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199803000-00009
更新日期：1998-03-01 00:00:00
abstract：:Adult male rats were housed in a colony environment for six months, with ad lib access to anise-flavored 10% ethanol in water. Animals were then removed from the colony, and their consumption of alcohol during a period in isolated housing was measured. Individual rats were scored as high, moderate, and low consumers. ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198309000-00009
更新日期：1983-09-01 00:00:00
abstract：:Fas-apoptotic inhibitory molecule 2 (Faim2) is a neuron-specific membrane protein and a member of the evolutionary conserved lifeguard apoptosis regulatory gene family. Its neuroprotective effect in acute neurological diseases has been demonstrated in an in vivo model of focal cerebral ischemia. Here we show that Faim...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0000000000000020
更新日期：2014-01-01 00:00:00
abstract：:Two basic proteins, P1 of molecular weight 14,200 and P2 of molecular weight 12,300, purified from bovine peripheral nerve, were assayed for biological activity. The P1 protein is an exclusively neuritogenic agent, capable of producing clinical signs of experimental allergic neuritis (EAN) and histological abnormaliti...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-197501000-00004
更新日期：1975-01-01 00:00:00
abstract：:Peripheral neuropathy is a significant complication of diabetes resulting in increased patient morbidity and mortality. Deficiencies of neurotrophic substances (e.g. NGE NT-3, and IGF-I) have been proposed as pathogenetic mechanisms in the development of distal symmetrical sensory diabetic polyneuropathy, and salutary...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/60.3.263
更新日期：2001-03-01 00:00:00
abstract：:We report a novel case of a World Health Organization grade 3 anaplastic meningioma arising from the olfactory groove in an 83-year-old woman. Molecular and methylation profiling confirm this lesion to be an NF2 subtype, methylation class intermediate type B meningioma. As most meningiomas in this location are indolen...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlx094
更新日期：2017-12-01 00:00:00
abstract：:A number of studies have implicated a proline-directed protein kinase, glycogen synthase kinase-3 (GSK-3) in the hyperphosphorylation of tau in Alzheimer's disease (AD). Toward understanding the role of GSK-3 in the abnormal hyperphosphorylation of tau in AD we have found that GSK-3 is prominently present in neuronal ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199701000-00007
更新日期：1997-01-01 00:00:00
abstract：:The periaqueductal gray (PAG) plays a central role in the integration of defense responses to threatening or stressful stimuli. Little is known about the neurochemical development of the human PAG around the time of birth, when the fetus makes the transition to extrauterine life and independent defense responses are n...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199604000-00003
更新日期：1996-04-01 00:00:00
abstract：:Brain arteriovenous malformations (bAVMs) are congenital anomalies of blood vessels that cause intracranial hemorrhage in children and young adults. Chromosomal rearrangements and fusion genes play an important role in tumor pathogenesis, though the role of fusion genes in bAVM pathophysiological processes is unclear....
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlaa126
更新日期：2021-01-01 00:00:00
abstract：:The development and differentiation of oligodendrocytes (OC) in developing mouse spinal cord (MSC) were investigated by correlative analysis of light and electron microscopy (EM), and immunoperoxidase studies for glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP). The sequential development of glial...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198609000-00003
更新日期：1986-09-01 00:00:00
abstract：:The aim of this study was to clarify pathological and anatomical relationships between adamantinomatous craniopharyngiomas (ACP) and their surrounding structures. We previously established a QST classification scheme based on the apparent anatomic origin of the tumors. According to this classification, 13 type Q tumor...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nly083
更新日期：2018-11-01 00:00:00
abstract：:Alpha-synuclein (alpha-synuclein) lesions are characteristic of idiopathic Parkinson disease (PD) and other alpha-synucleinopathies. To study the frequency of alpha-synuclein lesions in normal aging and how frequently they coexist with lesions of Alzheimer disease (AD), we examined the autopsy brains from normal and d...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/64.2.156
更新日期：2005-02-01 00:00:00
abstract：:The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immun...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/61.5.413
更新日期：2002-05-01 00:00:00
abstract：:Infection with human immunodeficiency virus (HIV) clade C is the most common HIV infection worldwide, yet its impact on the nervous system remains largely unknown. Autopsy studies from regions affected by this virus are scarce, and HIV dementia has only rarely been reported from these countries. Most patients who deve...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e3181461d3e
更新日期：2007-09-01 00:00:00
abstract：:In a recent study we estimated the number and frequency distribution of the diameters of the cytons of all of the combined motoneuron columns of L3, L4 and L5 ventral horn of the spinal cord of man. In the present study we have estimated the number and frequency distribution of the diameter of motoneuron cytons in the...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-197711000-00007
更新日期：1977-11-01 00:00:00
abstract：:The light and electron microscopic features of an unique retroperitoneal ganglioneuroblastoma in a four-year-old female are described. The unprecedented concurrence of Hirano, zebra, membranous cytoplasmic (MCB), and Pick bodies in the same population of neoplastic, sympathetic ganglion cells provides further evidence...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-197601000-00002
更新日期：1976-01-01 00:00:00
abstract：:Increasing evidence has demonstrated a vital role of microRNAs (miRNAs) in diverse biological processes. However, their functions in developing brain with hypoxia-ischemia (HI) remain largely unknown. Through a miRNA microarray analysis in a P10 rat model of cerebral HI, we found that miR-30d-5p was one of the most de...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlx052
更新日期：2017-08-01 00:00:00
abstract：:The aim of this study was to clarify the relationship between craniopharyngiomas (CP) and the third ventricle floor by analyzing the membranes between them. Eight fetal specimens were first examined by hematoxylin and eosin and immunofluorescence staining to determine optimal markers for identifying membrane structure...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlaa087
更新日期：2020-09-01 00:00:00
abstract：:Precise temporal and spatial coordination of expression of the myogenic regulatory factors (MRF) plays a critical role in the development of skeletal muscle. Whether this pattern is recapitulated postnatally during regeneration of mature muscle after injury is not known. The aim of this study was to determine the cell...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199605000-00002
更新日期：1996-05-01 00:00:00
abstract：:During the Zika epidemic in Brazil, a baby was born at term with microcephaly and arthrogryposis. The mother had Zika symptoms at 10 weeks of gestation. At 17 weeks, ultrasound showed cerebral malformation and ventriculomegaly. At 24 weeks, the amniotic fluid contained ZIKV RNA and at birth, placenta and maternal bloo...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlx116
更新日期：2018-03-01 00:00:00
abstract：:In multiple sclerosis, remyelination becomes limited after repeated or prolonged episodes of demyelination. To test the effect of platelet-derived growth factor-A (PDGF-A) in recovery from chronic demyelination we induced corpus callosum demyelination using cuprizone treatment in hPDGF-A transgenic (tg) mice with the ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e3181587d46
更新日期：2007-11-01 00:00:00
