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An in vitro study on the photosensitivity of 5-aminolevulinic acid conjugated gold nanoparticles.

Abstract：

BACKGROUND:In this study, the photosensitivity of 5-aminolevulinic acid (5-ALA) conjugated gold nanoparticles (conjugate) has been investigated on the MeL-Rm cell line. METHODS:After culture and proliferation of the Mel-Rm cell line, cell toxicity and the suitable cell incubation time of the conjugate were determined. Photosensitivity of the conjugate and free 5-ALA was then studied in optical doses of 20, 40, 60 and 80 J/cm(2) while light irradiation was applied by a He-Ne laser. RESULTS:A 4-h time interval was determined as the optimum incubation time for 5-ALA and the conjugate. PpIX induction into the cells showed a significant increase after incubation with the conjugate in comparison to 5-ALA alone. Also, the conjugate resulted in a two times higher cell death rate compared to free 5-ALA. CONCLUSION:The conjugate can be used as an appropriate delivery agent for 5-ALA and provide efficient cell destruction during PDT.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Mohammadi Z,Sazgarnia A,Rajabi O,Soudmand S,Esmaily H,Sadeghi HR

doi

10.1016/j.pdpdt.2013.03.010

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

382-8

issue

4

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(13)00045-8

journal_volume

10

pub_type

杂志文章

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