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Multi-path tumor inhibition via the interactive effects between tumor microenvironment and an oxygen self-supplying delivery system for a photosensitizer.

Abstract：

:The tumor microenvironment (TME) affects not only tumor growth and metastasis, but also therapy efficacy. In the present study, an oxygen self-supplying delivery system for a photosensitizer (O2-PDS), with an oxygen source of calcium peroxide (CPO), has been designed to induce multi-path tumor apoptosis through interactive effects with the TME. In anti-tumor experiments, the CPO decomposition and O2 released from the O2-PDS are site-activated and accelerated by high interstitial pressure and low pH level of the TME. The CPO decomposition products of O2 and Ca2+ lead to direct tumor apoptosis by irradiation generated singlet oxygen and mitochondrial calcium overload. The decomposition products of OH- and O2 relieves the acid and hypoxic state of TME, inducing a decrease in tumor proliferation and metastasis. This multi-path tumor apoptosis leads to a positive therapeutic effect on an animal tumor model and nontoxicity in normal tissue.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Rui X,Yang Y,Wu J,Chen J,Chen Q,Ren R,Zhang Q,Hu Y,Yin D

doi

10.1016/j.pdpdt.2019.101642

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

101642

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(19)30587-3

journal_volume

29

pub_type

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