Abstract：
:Antimicrobial photodynamic therapy uses a nontoxic photosensitizer with the assistance of harmless visible light to activate the photosensitizer. Consequently, the excited state of the photosensitizer interacts with molecular oxygen to produce reactive oxygen species, which have the antimicrobial effect. In this study, we evaluated the effect of photodynamic therapy on Vero cells infected with rickettsia using methylene blue as a photosensitizer along with red light. A significant reduction (by 96%) in the number of viable Rickettsia slovaca was determined by quantitative RT-PCR 48 h after the treatment with methylene blue followed by 30 min of red light excitation. A statistically significant reduction of R. slovaca was also recorded with pretreatment (by 99%). To the best of our knowledge, this result is the first one in the literature to confirm the effectiveness of photodynamic therapy for the elimination of R. slovaca and to suggest this technique as a good supportive treatment for rickettsial infections.
journal_name
Photodiagnosis Photodyn Therjournal_title
Photodiagnosis and photodynamic therapyauthors
Špitalská E,Špitalský Z,Markovic Z,Štefanidesová K,Škultéty Ľdoi
10.1016/j.pdpdt.2018.09.018subject
Has Abstractpub_date
2018-12-01 00:00:00pages
150-152eissn
1572-1000issn
1873-1597pii
S1572-1000(18)30248-5journal_volume
24pub_type
杂志文章abstract：OBJECTIVES:To evaluate the bleaching efficacy of a violet radiation (VR) combined or not with bleaching gels on the color and mineral content of stained teeth. MATERIAL AND METHODS:Enamel/dentin blocks were obtained and stained (n = 50) with coffee, red wine, tobacco smoke, or were left non-stained. The stained or not...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2021.102194
更新日期：2021-01-26 00:00:00
abstract：:Extramedullary plasmacytomas (EMP) are rare plasma cell neoplasms that are mostly located in the mucosal surfaces of the upper aerodigestive tract. The standard treatment is radiotherapy (RT), with surgical resection reserved as salvage procedure. In this report a patient with a EMP, located in the nasopharynx and ref...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2011.03.340
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate validity and reliability of autofluorescence-based plaque quantification (APQ) method. METHODS:The facial surfaces of 600 sound anterior teeth of 50 subjects were examined. The subjects received dental plaque examination using Turesky modified Quigley Hein plaque index ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Photodynamic therapy (PDT) is a well-known and effective treatment for non-melanoma skin-cancer. Numerous studies have also shown its effectiveness in mycosis fungoides. The aim of the study was to analyse MF patients treated with PDT at the Dermatology Unit of Bologna University. METHODS:We retrospectively...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2017.09.004
更新日期：2017-12-01 00:00:00
abstract：:Medication-related osteonecrosis of the jaw (MRONJ) results in progressive destruction of the jawbones, and advanced cases demand surgical intervention. The total removal of necrotic bone is required to prevent recurrence and infection. However, determining the limits between necrotic and healthy bone is a challenge. ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章,评审
doi：10.1016/j.pdpdt.2020.102003
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Active recruitment of inflammatory cells into tumors may be vital for antitumor immunity in cutaneous squamous cell carcinoma (cSCC) after photodynamic therapy. Chemokines play important roles in inflammatory cell recruitment. Moreover, C-X-C motif chemokine ligand 13 (CXCL13) is thought to be a pivotal chem...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2019.04.018
更新日期：2019-06-01 00:00:00
abstract：:Hypericin photodynamic therapy (HypPDT) has been found to be an efficient inducer of cell death. However, there are indications that HypPDT also activates rescuing pathways. Cell responses to HypPDT are highly dependent on the Hyp intracellular localization and accumulation. We have shown previously that in U87 MG cel...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2014.02.010
更新日期：2014-06-01 00:00:00
abstract：:Hidradenitis Suppurativa (HS) is a distressing painful chronic inflammatory skin follicular condition. It is a challenge to achieve better therapeutic effect and lower recurrence rate. In this report, ALA-PDT combined with surgery for the treatment achieved ulcer healing, pain elimination, with no relapse during our f...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2019.07.024
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:Early diagnosis of tooth enamel demineralization, and dentin caries lesions, present a valuable solution to avoid or decrease their deleterious effect. The aim of this study was to design a simple, effective, and non-invasive technique, employing a novel laser wavelength to classify and differentiate between va...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2018.11.017
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Photodynamic therapy (PDT) can eliminate microorganisms in a root canal. However, the parameters for disinfection remain undefined. This study assessed the effectiveness of a PDT protocol against intracanal Enterococcus faecalis biofilms. MATERIALS AND METHODS:Root canals were contaminated wit...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2016.01.002
更新日期：2016-03-01 00:00:00
abstract：:Port wine stain (PWS) birthmarks are congenital vascular malformations characterized by ectatic capillaries in the papillary layer of the dermis. They usually appear at birth and tend to become darker and thicker with age. Cosmetic and pathological changes can cause great depression in all ages. Laser-mediated selecti...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章,评审
doi：10.1016/j.pdpdt.2009.08.001
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Photodynamic therapy has apart from a direct cytotoxic effect also immunomodulatory properties. The aim of our study was to investigate how photodynamic therapy with 5-aminolevulinic acid (ALA-PDT) in sublethal doses influences the secretion of interleukins 6, 8 and 10 from colon cancer cells in vitro. METH...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2018.02.021
更新日期：2018-06-01 00:00:00
abstract：:Today, the widespread use of laser instruments in various fields has resulted in many accidental retinal injuries. Here we describe a rare clinical case of full-thickness macular hole (MH) and focal choroidal excavation (FCE) caused by a 1064-nm Q-switched Nd:YAG laser. After pars plana vitrectomy and the following 14...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2017.07.001
更新日期：2017-09-01 00:00:00
abstract：:One of the factors limiting photodynamic therapy (PDT) is hypoxia in tumor cells during photodynamic action. PDT with pulse mode irradiation and appropriate irradiation parameters could be more effective in the singlet oxygen generation and tissue re-oxygenation than continuous wave (CW) mode. We theoretically demonst...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2016.01.003
更新日期：2016-03-01 00:00:00
abstract：:The success of PDT and its establishment into the existent hall of therapeutic modalities depends on the collection of reported experiences from around the world. In that sense, it is important to report approaches taken by different countries and what their views are on the future of PDT. Following this idea, we pres...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/S1572-1000(05)00058-X
更新日期：2005-06-01 00:00:00
abstract：INTRODUCTION:Photodynamic therapy is an innovative treatment modality, which is appropriate for tumor detection and for the treatment of cancer as well as nontumoral diseases, such as psoriasis (2), bacterial and viral eradication. MATERIAL AND METHOD:Effect of two photosensitizer (toluidine blue O (TBO) and Radachlor...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2016.07.001
更新日期：2016-09-01 00:00:00
abstract：:Molecular modification of protoporphyrin IX (PpIX) was conducted to improve its water solubility and therapeutic performance for photodynamic therapy. The carboxylic acid and the two nitrogen atoms in the core of PpIX molecule were protonated following by conjugation with 3-aminopropyl triethoxysilane (APTES). Then, f...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2015.01.003
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Optical fibres can be placed in balloons to deliver light for intracranial photodynamic therapies. METHOD:A series of fibres, with either cleaved ends or terminating in cylindrical diffusers, housed in two different balloons, containing various solutions were investigated. The aim of the experiments perform...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2007.06.003
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:This study investigated the relationship between manual dexterity and dental biofilm accumulation in independent older Koreans using Quantitative Light-Induced Fluorescence-Digital (QLF-D). METHODS:This cross-sectional study included 44 participants recruited from senior welfare facilities in South Korea an...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章,多中心研究
doi：10.1016/j.pdpdt.2018.11.007
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:To analyze the clinical efficacy of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating port-wine stains (PWS), and its clinical operation skills and operation essentials. METHOD:A total of 16 cases of PWS with negative HMME skin test results were included in this study. Their treate...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章,评审
doi：10.1016/j.pdpdt.2017.09.013
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Epithelial non-melanoma skin cancer (NMSC) like actinic keratosis (AK), Bowen's disease (BD) and basal cell carcinoma (BCC) represent the most common malignancies in the fair skinned population. Epidemiological data reveal high incidences, especially for actinic keratoses, which are basically non-invasive sq...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章,评审
doi：10.1016/j.pdpdt.2009.12.004
更新日期：2010-03-01 00:00:00
abstract：:Photophysical and in vitro photocytotoxicity studies were performed for the photosensitizer Dimegine, a disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX with very low systemic toxicity. The singlet oxygen and luminescence quantum yield were ΦΔ = 0,65 ± 0,06, and Φƒ=0,11 ± 0,01 respectively, and were indepe...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2018.11.006
更新日期：2019-03-01 00:00:00
abstract：:Photodynamic effect was a chance discovery early in the 1900s, demonstrating the lethal effects of light activated chemicals on living cells. Although the application of the principles of photodynamic effect to patients' treatment and what became photodynamic therapy (PDT) was practiced in 1960s and 1970s, clinical tr...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章,评审
doi：10.1016/j.pdpdt.2008.04.004
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Photodynamic therapy (PDT) is a good option for the treatment of Bowen's disease (BD). However, BD occasionally can progress into a squamous cell carcinoma (SCC) after PDT. OBJECTIVE:Find predictors of aggressiveness of BD after PDT METHODS: Two biopsies of patients with BD treated with PDT with progression...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2018.02.004
更新日期：2018-06-01 00:00:00
abstract：:In this review article we described the applications of various nanoparticles that can be used for photodynamic therapy (PDT), such as: plasmonic nanoparticles, quantum dots and upconversion nanoparticles. In comparison with typical organic photosensitizers such as hematoporphyrins, they exhibit higher photostability ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章,评审
doi：10.1016/j.pdpdt.2019.03.016
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:The aim of the present 6-month follow-up study was to assess the effect of mechanical debridement (MD) with adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of peri-implant diseases in type-2 diabetic smokers and non-smokers. METHODS:Patients were divided into 2 groups: (a) Group-1: type-2 ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2016.11.005
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:Evaluate the efficacy of 5-Aminolevulinic Acid Photodynamic Therapy (PDT) in medical treatment of nasal inverted papilloma (NIP). METHODS:Three patients with nasal inverted papilloma were treated with 5-Aminolevulinic Acid Photodynamic Therapy at our department from April to September 2012. The efficacy and ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2013.05.010
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:The aim of this pilot study was to compare the efficacy of ALA-PDT and red light alone in the treatment of photoaging. METHODS:A total of 14 adults with photoaging skin were recruited. ALA-PDT or red light alone was applied to the forearm extensor. Before and after treatment, the treated sites were examined ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2014.02.007
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Early diagnosis of non-melanoma skin cancer (NMSC) is potentially possible using optical coherence tomography (OCT) which provides non-invasive, real-time images of skin with micrometre resolution and an imaging depth of up to 2mm. OCT technology for skin imaging has undergone significant developments, impro...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2016.08.004
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Increasing resistance of oral pathogens to conventional antibacterial agents has resulted to find alternative therapies to overcome resistance development problems; hence this in vitro study was carried out to investigate the efficacy of photoelimination of Streptococcus mutans with two methods of photodynam...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2013.07.002
更新日期：2013-12-01 00:00:00
