当前位置： SCI文献检索 > Photodiagnosis and Photodynamic Therapy期刊下所有文献 > Photophysical properties and in vitro photocytotoxicity of disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX (Dimegine).

Photophysical properties and in vitro photocytotoxicity of disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX (Dimegine).

Abstract：

:Photophysical and in vitro photocytotoxicity studies were performed for the photosensitizer Dimegine, a disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX with very low systemic toxicity. The singlet oxygen and luminescence quantum yield were ΦΔ = 0,65 ± 0,06, and Φƒ=0,11 ± 0,01 respectively, and were independent of the excitation wavelength. The photobleaching coefficients for Dimegine dissolved in phosphate buffer (pH 7.4), and DMEM medium at concentration 2 μM/l and in phosphate buffer (pH 7.0) at concentration 10 μM/l were 16·10-5, 9·10-5 and 2·10-5 respectively. In vitro cellular distribution and photocytotoxicity was studied in two human (U87 - primary glioblastoma and HT1376 - bladder cancer) and two rat cell lines (RG2 - glioma, and AY27 - bladder carcinoma). Fluorescence microscopy analysis shows primary Dimegine accumulation as small fluorescent inclusion bodies around the nuclei, suggesting an apoptotic over a necrotic cell death mechanism. The PDT efficacy was slightly higher for the rat cell lines over the human-derived cell lines, with LD50 values of 2,5 μM/l, 2.8 μM/l, 4.5 μM/l, 2.8 μM/l using 530 nm excitation wavelength for AY27, RG2, HT1376 and U87 respectively, and 1.8 μM/l, 2 μM/l, 5 μM/l, 2.4 μM/l using 625 nm excitation wavelength for AY27, RG2, HT1376 and U87 respectively. Comparison to literature data showed that Dimegine demonstrated improved phototherapeutic characteristics comparing to PpIX-mediated PDT.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Dadeko AV,Lilge L,Kaspler P,Murav'eva TD,Starodubtcev AM,Kiselev VM,Zarubaev VV,Ponomarev GV

doi

10.1016/j.pdpdt.2018.11.006

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

35-42

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(18)30308-9

journal_volume

25

pub_type

杂志文章

相关文献

Photodiagnosis and Photodynamic Therapy文献大全
  • Vascular targeted photodynamic therapy for bleeding gastrointestinal mucosal vascular lesions: a preliminary study.

    abstract：BACKGROUND:Vascular-targeted photodynamic therapy (V-PDT) has shown good selectivity and efficacy in the treatment of certain types of vascular disease, including port wine stains, age-related macular degeneration, and esophageal varices. This study was conducted to test the efficacy and safety of V-PDT in the treatmen...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2011.11.003

    authors： Qiu H,Mao Y,Gu Y,Wang Y,Zhu J,Zeng J

    更新日期：2012-06-01 00:00:00

  • Taking treatment decisions in non-melanoma skin cancer--the place for topical photodynamic therapy (PDT).

    abstract：BACKGROUND:Epithelial non-melanoma skin cancer (NMSC) like actinic keratosis (AK), Bowen's disease (BD) and basal cell carcinoma (BCC) represent the most common malignancies in the fair skinned population. Epidemiological data reveal high incidences, especially for actinic keratoses, which are basically non-invasive sq...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,评审

    doi：10.1016/j.pdpdt.2009.12.004

    authors： Sidoroff A,Thaler P

    更新日期：2010-03-01 00:00:00

  • Conjunction of glutathione level, NAD(P)H/FAD redox status and hypericin content as a potential factor affecting colon cancer cell resistance to photodynamic therapy with hypericin.

    abstract：BACKGROUND:Photodynamic therapy (PDT) is a highly efficient approach for tumour therapy, though it also has its drawbacks, too. There are multiple mechanisms involved in cell death regulation that can be successfully targeted for improvement of PDT in particular cases. We assumed, however, that the potential to manage ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2013.04.003

    authors： Mikešová L,Mikeš J,Kovaľ J,Gyurászová K,Culka L,Vargová J,Valeková B,Fedoročko P

    更新日期：2013-12-01 00:00:00

  • Photodynamic activity and DNA binding studies of Pd@SiO2 core-shell nanoparticles in vitro.

    abstract：:Metal-semiconductor core-shell type Pd@SiO2 nanoparticles (NPs) were successfully synthesized by Stober's method and the product was characterized by UV-vis, XRD, FT-IR, SEM, HR-TEM and EDX techniques. In vitro Photodynamic activity and DNA binding studies of Pd@SiO2 core shell nanoparticles were studied. Cell viabili...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.03.008

    authors： Dhanalekshmi KI,Sangeetha K,Meena KS,Magesan P,Manikandan A,Jayamoorthy K

    更新日期：2019-06-01 00:00:00

  • Photodynamic therapy (PDT) for lung cancer: the Yorkshire Laser Centre experience.

    abstract：BACKGROUND:The Yorkshire Laser Centre team have been engaged in photodynamic therapy (PDT) since 1990. In this article we review our experience in bronchoscopic PDT for lung cancer and outline our current indications and results. METHODS:160 patients in 2 groups entered into a prospective study: Group A (N=144) were s...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/S1572-1000(04)00047-X

    authors： Moghissi K,Dixon K,Thorpe JA,Oxtoby C,Stringer MR

    更新日期：2004-11-01 00:00:00

  • Comparison between the outcomes of fluorescein angiography-guided and indocyanine green angiography-guided half-time photodynamic therapy for central serous chorioretinopathy.

    abstract：BACKGROUND AND OBJECTIVES:This study aimed to compare the efficacy of fluorescein angiography (FA)-guided and indocyanine green angiography (ICGA)-guided half-time photodynamic therapy (PDT) for central serous chorioretinopathy (CSC). SUBJECTS AND METHODS:Medical records of 61 eyes of 61 CSC patients who underwent hal...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101955

    authors： Hayashida M,Miki A,Honda S,Nakamura M

    更新日期：2020-09-01 00:00:00

  • Combining Magnetic Resonance Imaging (MRI) and Medical Infrared Thermography (MIT) in the pre- and peri-operating management of severe Hidradenitis Suppurativa (HS).

    abstract：:Hidradenitis suppurativa (HS) is a chronic, inflammatory, and recurrent skin disease. Surgical excision of wounds appears to be the only curative treatment for the prevention of recurrence of moderate to severe stages. Magnetic resonance imaging (MRI) is a standard reference examination for the detection of HS peri-an...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.05.007

    authors： Derruau S,Renard Y,Pron H,Taiar R,Abdi E,Polidori G,Lorimier S

    更新日期：2018-09-01 00:00:00

  • Endoscopic photodynamic therapy for oesophageal disease.

    abstract：:Photodynamic therapy is a very important technique for the eradication of widespread oesophageal mucosal disease which has the potential to degenerate to cancer. Patients unsuitable or unwilling to undergo radical therapy can be cured using photodynamic therapy. We predominantly treat patients with high-grade dysplasi...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2006.03.008

    authors： Barr H,Kendall C,Bazant-Hegemark F,Stone N

    更新日期：2006-06-01 00:00:00

  • Therapeutic evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in Bowenoid papulosis.

    abstract：BACKGROUND:Bowenoid papulosis is a polymorphic papular disease that occurs on the external genital area. We investigated the efficacy of 5-aminolevulinic acid-mediated photodynamic therapyin the treatment of Bowenoid papulosis. METHODS:We investigated 200 Bowenoid papulosis cases from the Department of Dermatology and...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.101635

    authors： Che Q,Li J,Wang J,Wang Q,Jiang L,Li Z,Liu H,Zhang M,Zeng K

    更新日期：2020-03-01 00:00:00

  • Comparison of antibacterial effect of photodynamic therapy using indocyanine green (Emundo) with 2% metronidazole and 2% chlorhexidine gel on Porphyromonas gingivalis (an in-vitro study).

    abstract：BACKGROUND:The treatment of periodontal disease focuses on eradication or suppression of the pathogenic microbiota within the periodontal pocket. There are some mechanical and chemical ways, and recently antimicrobial photodynamic therapy to eliminate the bacteria. The aim of this in vitro study was to compare the effe...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.04.003

    authors： Fekrazad R,Karamifar K,Bahador A

    更新日期：2016-09-01 00:00:00

  • An in vitro study on the photosensitivity of 5-aminolevulinic acid conjugated gold nanoparticles.

    abstract：BACKGROUND:In this study, the photosensitivity of 5-aminolevulinic acid (5-ALA) conjugated gold nanoparticles (conjugate) has been investigated on the MeL-Rm cell line. METHODS:After culture and proliferation of the Mel-Rm cell line, cell toxicity and the suitable cell incubation time of the conjugate were determined....

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2013.03.010

    authors： Mohammadi Z,Sazgarnia A,Rajabi O,Soudmand S,Esmaily H,Sadeghi HR

    更新日期：2013-12-01 00:00:00

  • Comparison of photodynamic treatment produced cell damage between human breast cancer cell MCF-7 and its multidrug resistance cell.

    abstract：BACKGROUND:Multidrug resistance (MDR) of breast cancer is a major obstacle in chemotherapy of cancer treatments. Recently the anti-tumor effects of Chlorin e6 (Ce6) mediated photodynamic therapy (Ce6-PDT) were reported in skin cancer and hepatoma in vitro. However, its therapeutic potential in killing human breast canc...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.07.004

    authors： Wang H,Li L,Wang P,Wang X,Zhang K,Liu Q

    更新日期：2016-12-01 00:00:00

  • Photodiagnosis and treatment of condyloma acuminatum using 5-aminolevulinic acid and homemade devices.

    abstract：BACKGROUND:The objective of this study was to improve the feasibility of applying topic 5-aminolevulinic acid (ALA) in photodiagnosis (PD) and treatment of condyloma caused by human papillomavirus (HPV) using two homemade handheld devices and to discuss the photodynamic therapy (PDT) as a suitable alternative for each ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pdpdt.2011.09.001

    authors： Inada NM,Costa MM,Guimarães OC,Ribeiro Eda S,Kurachi C,Quintana SM,Lombardi W,Bagnato VS

    更新日期：2012-03-01 00:00:00

  • In vitro evaluation of methylene blue removal from root canal after Photodynamic Therapy.

    abstract：:In Endodontics, photosensitizers' such as methylene blue and toluidine blue have been used in Photodynamic Therapy due to their positive results. However, they can stain the dentin from the root canal after Photodynamic Therapy (PDT). The present in vitro study aimed to evaluate different stain removal protocols from ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2017.10.024

    authors： Ramalho KM,Cunha SR,Mayer-Santos E,Eduardo CP,Freitas PM,Aranha ACC,Moura-Netto C

    更新日期：2017-12-01 00:00:00

  • Ultraviolet radiation exposure during daylight Photodynamic Therapy.

    abstract：BACKGROUND:Daylight photodynamic therapy (dPDT) is an effective treatment for field-change actinic keratoses (AK), with similar efficacy to conventional PDT but lower patient pain scores. Whilst AK occur consequent to chronic solar ultraviolet (UV) exposure, paradoxically solar visible radiation is used during PDT. OB...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.05.020

    authors： McLellan LJ,O'Mahoney P,Khazova M,Higlett M,Ibbotson SH,Eadie E

    更新日期：2019-09-01 00:00:00

  • Comparison of 5-aminolevulinic acid photodynamic therapy and red light for treatment of photoaging.

    abstract：OBJECTIVE:The aim of this pilot study was to compare the efficacy of ALA-PDT and red light alone in the treatment of photoaging. METHODS:A total of 14 adults with photoaging skin were recruited. ALA-PDT or red light alone was applied to the forearm extensor. Before and after treatment, the treated sites were examined ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2014.02.007

    authors： Ji J,Zhang LL,Ding HL,Wang HW,Huang Z,Wang XX,Wang PR,Wang XL

    更新日期：2014-06-01 00:00:00

  • Photodynamic effect of curcumin on Vibrio parahaemolyticus.

    abstract：:Vibrio parahaemolyticus (V. parahaemolyticus) is currently a major cause of bacterial diarrhoea associated with seafood consumption. The objective of this study was to determine the inactivation effect of curcumin-mediated photodynamic action on V. parahaemolyticus. First of all, V. parahaemolyticus suspended in PBS b...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.05.004

    authors： Wu J,Mou H,Xue C,Leung AW,Xu C,Tang QJ

    更新日期：2016-09-01 00:00:00

  • Autofluorescence spectroscopy for NADH and flavoproteins redox state monitoring in the isolated rat heart subjected to ischemia-reperfusion.

    abstract：BACKGROUND:Reduction of myocardial ischemia-reperfusion injury in the patients undergoing cardiac surgery under cardiopulmonary bypass represents an important goal. Intraoperative monitoring of myocardial metabolic state using continuous registration of nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucl...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2014.05.003

    authors： Papayan G,Petrishchev N,Galagudza M

    更新日期：2014-09-01 00:00:00

  • Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.

    abstract：BACKGROUND:Although aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy (PDT) is an effective FDA-approved therapy for actinic keratosis (AK), a substantial fraction of patients (up to 25%) do not respond to treatment. This study examined the feasibility of using pre-treatment measurements o...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pdpdt.2015.10.006

    authors： Kanick SC,Davis SC,Zhao Y,Sheehan KL,Hasan T,Maytin EV,Pogue BW,Chapman MS

    更新日期：2015-12-01 00:00:00

  • Red fluorescence of plaque in the dentition-a comparison of Quantitative Light-induced Fluorescence-Digital (QLF-D) images and conventional images of disclosed plaque.

    abstract：BACKGROUND:Quantitative Light-induced Fluorescence-Digital (QLF-D) detects red fluorescence of plaque, but is almost solely used on labial anterior tooth surfaces. As distribution and formation of plaque varies distinctly within the dentition, our aim was to investigate, how red fluorescing plaque is related to disclos...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102063

    authors： Ganss C,Glanz A,Glanz T,Schlueter N,Ruf S

    更新日期：2020-12-01 00:00:00

  • Effect of Photofrin-mediated photocytotoxicity on a panel of human pancreatic cancer cells.

    abstract：BACKGROUND AND OBJECTIVE:Pancreatic cancer is a leading cause of cancer-related deaths in men and women. Early clinical studies suggest that photodynamic therapy (PDT) might be a useful modality in the management of this deadly disease. In this study, the photocytotoxicity of Photofrin-mediated PDT on different human p...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.11.001

    authors： Wang LW,Huang Z,Lin H,Li ZS,Hetzel F,Liu Md B

    更新日期：2013-09-01 00:00:00

  • Photodynamic therapy with the use of superluminescent diodes (sLED) in the treatment of actinic keratosis.

    abstract：BACKGROUND:Superluminescent diodes (sLED) appear to be an innovative and promising light source in photodynamic therapy (PDT), especially in actinic keratosis (AK) lesions treatment. AIM:Assessment of tolerability and efficacy of sLED in topical 5-aminolevulinic acid (ALA) PDT of AK lesions. METHODS:27 patients recei...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.04.010

    authors： Bartosińska J,Wolska-Gawron K,Gerkowicz A,Niewiedzioł M,Michalska-Jakubus M,Komza M,Klepaczewski T,Kwaśny M,Krasowska D

    更新日期：2018-06-01 00:00:00

  • Conventional versus daylight photodynamic therapy for actinic keratosis: A randomized and prospective study in China.

    abstract：BACKGROUND:Conventional photodynamic therapy (C-PDT) is an effective treatment for actinic keratoses (AKs) in Asia, with some unmet needs. Severe PDT-associated pain results in low treatment willingness. Daylight photodynamic therapy (DL-PDT) is a more simple and tolerable treatment that has the same efficacy as C-PDT ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pdpdt.2018.10.010

    authors： Zhu L,Wang P,Zhang G,Zhang L,Liu X,Hu C,Yang X,Sroka R,Zhou Z,Wang X

    更新日期：2018-12-01 00:00:00

  • Effectiveness of final decontamination protocols against Enterococcus faecalis and its influence on bond strength of filling material to root canal dentin.

    abstract：AIM:The aim of this study was to evaluate the effectiveness of final decontamination protocols against Enterococcus faecalis and their influence on bond strength of filling material to root canal dentin. MATERIAL AND METHODS:Ninety root canals were enlarged with ProTaper system and inoculated with E. faecalis for 15da...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.11.004

    authors： Albino Souza M,Dalla Lana D,Gabrielli E,Barbosa Ribeiro M,Miyagaki DC,Cecchin D

    更新日期：2017-03-01 00:00:00

  • Optical coherence tomography in the diagnosis of actinic keratosis-A systematic review.

    abstract：BACKGROUND:Optical coherence tomography (OCT) is a real-time non-invasive imaging tool, introduced in dermatology in the late 1990s. OCT uses near-infrared light impulses to produce images which can be displayed in cross-sectional and en-face mode. The technique has been used to image skin diseases especially non-melan...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,评审

    doi：10.1016/j.pdpdt.2017.02.003

    authors： Friis KBE,Themstrup L,Jemec GBE

    更新日期：2017-06-01 00:00:00

  • Pulse mode of laser photodynamic treatment induced cell apoptosis.

    abstract：:One of the factors limiting photodynamic therapy (PDT) is hypoxia in tumor cells during photodynamic action. PDT with pulse mode irradiation and appropriate irradiation parameters could be more effective in the singlet oxygen generation and tissue re-oxygenation than continuous wave (CW) mode. We theoretically demonst...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.01.003

    authors： Klimenko VV,Knyazev NA,Moiseenko FV,Rusanov AA,Bogdanov AA,Dubina MV

    更新日期：2016-03-01 00:00:00

  • Monitoring PDT effects in basal cell carcinoma treatment using thermal imaging.

    abstract：BACKGROUND:One of the most frequent type of malignant skin lesion (almost 95 percent of all skin tumours) is basal cell carcinoma (BCC). It is often treated by radiotherapy using ionizing radiation as well by photodynamic therapy (PDT) which is a selective method directed only on cancer cells and well tolerated by pati...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101845

    authors： Kapek Ł,Cholewka A,Szurko A,Sieroń K,Sieroń A,Kwiatek S,Stanek A

    更新日期：2020-09-01 00:00:00

  • Single treatment of low-risk basal cell carcinomas with pulsed dye laser-mediated photodynamic therapy (PDL-PDT) compared with photodynamic therapy (PDT): A controlled, investigator-blinded, intra-individual prospective study.

    abstract：BACKGROUND AND OBJECTIVE:To compare a single treatment of PDL-PDT with PDT for BCCs in terms of efficacy, aesthetic outcome, and pain in patients with multiple BCCs. STUDY DESIGN/MATERIALS AND METHODS:A prospective, controlled, intra-individual, investigator-blinded study was conducted on 15 patients with 62 BCCs. The...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.08.003

    authors： Čarija A,Puizina-Ivić N,Vuković D,Mirić Kovačević L,Čapkun V

    更新日期：2016-12-01 00:00:00

  • Effects of low-dose ALA-PDT on fibroblast photoaging induced by UVA irradiation and the underlying mechanisms.

    abstract：OBJECTIVES:To investigate the effects of low-dose aminolevulinic acid photodynamic therapy (ALA-PDT) on photoaging in human dermal fibroblasts (HDFs) and to explore the mechanism of Nuclear factor erythroid 2-related factor 2(Nrf2)-mediated photorejuvenation in vitro. METHODS:A photoaging model was established through...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.05.006

    authors： Chen J,Luo J,Tan Y,Wang M,Liu Z,Yang T,Lei X

    更新日期：2019-09-01 00:00:00

  • Temperature effect on the PpIX production during the use of topical precursors.

    abstract：:Decreasing incubation time, as well as enhanced PpIX production, are present challenges for topical photodynamic therapy (PDT). There are reports concerning the existence of a strong relationship between site temperature and porphyrin synthesis in biological tissue, that suggest temperature increase in the tissue can ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101786

    authors： Stringasci MD,Moriyama LT,Vollet-Filho JD,Bagnato VS

    更新日期：2020-06-01 00:00:00