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Photodynamic activity and DNA binding studies of Pd@SiO2 core-shell nanoparticles in vitro.

Abstract：

:Metal-semiconductor core-shell type Pd@SiO2 nanoparticles (NPs) were successfully synthesized by Stober's method and the product was characterized by UV-vis, XRD, FT-IR, SEM, HR-TEM and EDX techniques. In vitro Photodynamic activity and DNA binding studies of Pd@SiO2 core shell nanoparticles were studied. Cell viability of the core-shell nanoparticles against HeLa cell line was screened by MTT assay after exposing at different light doses. The outcome of the present study indicates that the core-shell Pd@SiO2 NPs are highly stable and exhibited strong photodynamic efficiency under LED light illumination in HeLa cells. The results indicated that SiO2 supported on the surface of Pd NPs not only prevented the aggregation in addition exhibited remarkable photodynamic activity.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Dhanalekshmi KI,Sangeetha K,Meena KS,Magesan P,Manikandan A,Jayamoorthy K

doi

10.1016/j.pdpdt.2019.03.008

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

79-84

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(18)30247-3

journal_volume

26

pub_type

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