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Potential of cationic porphyrins for photodynamic treatment of cutaneous Leishmaniasis.

Abstract：

:Four tetracationic porphyrins have been investigated for their ability to photo-inactivate Leishmania major promastigotes. Parallel photocytotoxicity assays against keratinocytes and macrophages show significant differences in activity between the microorganism and mammalian cells. Results suggest that it may be possible to photodynamically inactivate macrophages infected with Leishmania and the promastigote form of the microorganism, while minimising damage to surrounding tissue.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Bristow CA,Hudson R,Paget TA,Boyle RW

doi

10.1016/j.pdpdt.2006.04.004

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

162-7

issue

3

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(06)00064-0

journal_volume

3

pub_type

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