Abstract：
BACKGROUND:Among the pathogens, Staphylococcus aureus is the main causative agent of bacterial diseases in the world. In this context, antimicrobial photodynamic therapy (aPDT) appears as a promising tool by means of microbial inactivation with the use of light. aPDT is applied in treatments involving photosensitizers capable of generating oxygen free radicals. Thus, this work proposes the use of resveratrol as a photosensitizer. METHODS:In vitro tests were performed to determine the antibacterial activity of photoactivated resveratrol with blue LED light, as well as uric acid experiments for verification of singlet oxygen formation. Possible resveratrol structural changes were evaluated by HPLC. In the in vivo assays, the air pouch model was performed in mice for antimicrobial activity and cytokine production. RESULTS:The photoactivated resveratrol exhibited an increase in its antibacterial action and it is possibly brought about by the singlet oxygen formation. In the air pouch model, TNF-α and IL-17A cytokines were produced, diminishing the bacterial load, and consequently, reducing inflammation after 24 h of infection. Cellular number decrease in the inflammatory environment was associated with resolution of inflammation along with greater IL-10 production. CONCLUSION:It is the first time that resveratrol has been associated with aPDT. It was demonstrated in this work that resveratrol activated by blue LED light can be a promising photosensitizer. This compound, after the light stimulus, produces singlet oxygen, in addition to having effects on the immune system triggering TNF-α and IL-17A production, aiding in the clearance of several bacteria, including S. aureus.
journal_name
Photodiagnosis Photodyn Therjournal_title
Photodiagnosis and photodynamic therapyauthors
Dos Santos DP,Soares Lopes DP,de Moraes RC Junior,Vieira Gonçalves C,Pereira Rosa L,da Silva Rosa FC,da Silva RAAdoi
10.1016/j.pdpdt.2019.01.005subject
Has Abstractpub_date
2019-03-01 00:00:00pages
227-236eissn
1572-1000issn
1873-1597pii
S1572-1000(18)30229-1journal_volume
25pub_type
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2011.11.003
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abstract：BACKGROUND:Photodynamic diagnosis (PDD) as well as thermovision belong to the category of non-invasive optical diagnosis techniques. Among many different skin cancer diseases, basal cell carcinoma (BCC) is the most frequently occurring one (almost 95% of all skin tumours). In contrast, seborrhoeic keratosis represents ...
journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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abstract：:In Endodontics, photosensitizers' such as methylene blue and toluidine blue have been used in Photodynamic Therapy due to their positive results. However, they can stain the dentin from the root canal after Photodynamic Therapy (PDT). The present in vitro study aimed to evaluate different stain removal protocols from ...
journal_title：Photodiagnosis and photodynamic therapy
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journal_title：Photodiagnosis and photodynamic therapy
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abstract：INTRODUCTION:Clinical studies have shown the usefulness of antimicrobial photodynamic therapy (aPDT) as an adjunctive in periodontal therapy. These studies did not utilize indocyanine green (ICG) as a recently introduced photosensitizer. The aim of this study was to perform a full-mouth double-blind randomized controll...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 临床试验,杂志文章,随机对照试验
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