Abstract:
:Non-melanotic cutaneous cancers and melanoma are the main common type skin cancers worldwide. Despite many therapeutic options, therapeutic efficacy is not satisfied in all patients with advanced skin cancers, especially in melanoma. Photodynamic therapy (PDT) is a technology for skin disease treatment because of its high effectiveness, has no drug resistance and is easy to use compared with traditional therapy. Our previous study explored that autophagy plays an important role in the formation and development of SCC. But there was no evidence about the association between PDT with autophagy in skin cancers and the mechanism is also still unclear. In the study, we want to explore the effects of 5-aminolevulinic acid-PDT (ALA-PDT) on the skin cancers through autophagy regulation. The result showed that autophagy was regulated by ALA-PDT combined with or without 3-Methyladenine (3-MA) or 5-Fluoracil (5-FU), the proliferation of skin cancer cells A431 and A375 were suppressed while the apoptosis were induced by ALA-PDT and the effects can be enhanced by 3-MA or 5-FU pretreated. The results suggest that autophagy regulation may be a key point of ALA-PDT therapy; ALA-PDT combined with the chemotherapy of 3-FU or 5-FU may be a new strategy for treatment of skin cancers including non-melanotic cutaneous cancers or melanoma.
journal_name
Photodiagnosis Photodyn Therjournal_title
Photodiagnosis and photodynamic therapyauthors
Zhang L,Ji Z,Zhang J,Yang Sdoi
10.1016/j.pdpdt.2019.08.023subject
Has Abstractpub_date
2019-12-01 00:00:00pages
159-165eissn
1572-1000issn
1873-1597pii
S1572-1000(19)30168-1journal_volume
28pub_type
杂志文章abstract:BACKGROUND:The focal goal of this study is to identify optimal accumulation periods for ALA-induced PpIX in different healthy anatomical sites of human oral cavity and different types of abnormal mucosa to improve the accuracy of the clinical applications such as photodiagnosis and tissue grading. MATERIALS AND METHOD...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2010.06.006
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:We report on a Phase 1 trial of photodynamic therapy (PDT) for superficial head and neck (H&N) lesions. Due to known oxygen dependencies of PDT, translational measurements of lesion hemoglobin oxygen saturation (StO2) and blood volume (tHb) were studied for associations with patient outcomes. METHODS:PDT wi...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2017.10.015
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Vaginal intraepithelial neoplasia (VAIN) has a high-risk for recurrence and may precede genital cancers, such as vaginal cancer and/or other invasive diseases. Human papillomavirus (HPV)-induced VAIN may occur after loop electrosurgical excision procedures (LEEPs) or panhysterectomy. 5-aminolevulinic acid (A...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2020.101837
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:To evaluate the effect of the first acute anterior uveitis (AAU) attack on the choroid by using an image binarization tool on images from enhanced depth imaging (EDI)-optical coherence tomography (OCT) scans in patients with ankylosing spondylitis (AS). METHODS:In this study, three groups were formed: uveit...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2020.101778
更新日期:2020-09-01 00:00:00
abstract:AIM:The aim of present study was to assess and compare different conditioning methods (laser, PDT and conventional) on shear bond strength (SBS) of resin modified glass ionomer cement (RMGIC) bonded to composite (sandwich technique). MATERIAL AND METHODS:Fifty specimens were prepared from RMGIC and were packed in a te...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2020.101965
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Oral lichen planus (OLP) is a chronic inflammatory disease. There is no standard treatment modality for OLP. Recently, photodynamic therapy (PDT) has been advocated as a new treatment modality for OLP. AIM:The aim of the present study is to compare the effect of PDT using methylene blue (MB) as a photosensi...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2020.101677
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Although aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy (PDT) is an effective FDA-approved therapy for actinic keratosis (AK), a substantial fraction of patients (up to 25%) do not respond to treatment. This study examined the feasibility of using pre-treatment measurements o...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.pdpdt.2015.10.006
更新日期:2015-12-01 00:00:00
abstract:AIM:The aim of this in-vitro study is to investigate the shear bond strength (SBS) of Bioactive bulk fill restorative material (BARM) (Activa) by surface pre-treatment using Er,Cr:YSGG (ECL) on dentin in comparison to conventional dentin conditioning techniques. MATERIAL AND METHODS:Sixty extracted non-carious, non-fr...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2019.08.014
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Conventional photodynamic therapy (C-PDT) is an effective treatment for actinic keratoses (AKs) in Asia, with some unmet needs. Severe PDT-associated pain results in low treatment willingness. Daylight photodynamic therapy (DL-PDT) is a more simple and tolerable treatment that has the same efficacy as C-PDT ...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pdpdt.2018.10.010
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the effect of multiple sessions of antimicrobial photodynamic therapy (aPDT) on the treatment of experimental periodontitis (EP) in rats treated with chemotherapy. METHODS:Chemotherapy using 5-fluorouracil (5-FU) consisted of intraperitoneal administration of 60 and 40 ...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2018.11.014
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to develop a novel photosensitizer from traditional plant extracts and to investigate the photodynamic therapy (PDT) effect and mechanism of action of the novel photosensitizer on KB and Hep-2 cells. METHODS:Fluorescence emission, cell viability, and intracellular distribution of c...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2019.02.020
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) is a technique that uses light and a photosensitizer, converting local molecular oxygen into singlet oxygen, which eliminates a target unhealthy tissue. It has been increasingly used for the treatment of several diseases including skin disorders. Psoriasis is a chronic inflammatory...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2015.05.003
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Verrucous carcinoma of the penis is a rare disease characterized by verrucous lesions. The traditional treatment methods for verrucous carcinoma result in loss of sexual function are not satisfactory. The purpose of this study was to evaluate the safety and effect of topical aminolevulinic acid photodynamic ...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2018.08.015
更新日期:2018-12-01 00:00:00
abstract::Archival biopsy materials from 20 randomly selected asymptomatic volunteers from the Czech uranium miners (CZ UM) risk group (n=98) were examined for p21 and ki-67 immunostatning. There were 16 areas with normal respiratory epithelium and 22 areas with bronchial intra-epithelial neoplasia (IEN). Normal and IEN areas w...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/S1572-1000(04)00005-5
更新日期:2004-05-01 00:00:00
abstract::Photodynamic therapy (PDT) is a promising modality for the treatment of cancer. PDT involves administering a photosensitizing dye, i.e. photosensitizer, that selectively accumulates in tumors, and shining a light source on the lesion with a wavelength matching the absorption spectrum of the photosensitizer, that exert...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章,评审
doi:10.1016/j.pdpdt.2019.04.033
更新日期:2019-06-01 00:00:00
abstract::This study reports successful photodynamic inactivation of planktonic and biofilm cells of Enterococcus faecalis using Methylene Blue (MB) in combination with gold nanoparticles synthesized using the cell-free filtrate obtained from 3-day biomass of Trichoderma asperellum strain. Monodispersed colloidal gold nanoparti...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2019.05.042
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:One of the most frequent type of malignant skin lesion (almost 95 percent of all skin tumours) is basal cell carcinoma (BCC). It is often treated by radiotherapy using ionizing radiation as well by photodynamic therapy (PDT) which is a selective method directed only on cancer cells and well tolerated by pati...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2020.101845
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Nanosecond pulsed electric field (nsPEF) treatment is a new anti-cancer strategy with ultrashort pulse duration and high intensity of electric fields. The application of nsPEFs affects all intra- and extracellular membranes and independently initiates the process of apoptosis within cancer cells, leading the...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2015.11.002
更新日期:2015-12-01 00:00:00
abstract::The tumor microenvironment (TME) affects not only tumor growth and metastasis, but also therapy efficacy. In the present study, an oxygen self-supplying delivery system for a photosensitizer (O2-PDS), with an oxygen source of calcium peroxide (CPO), has been designed to induce multi-path tumor apoptosis through intera...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2019.101642
更新日期:2020-03-01 00:00:00
abstract:INTRODUCTION:Photodynamic therapy (PDT) is a minimally invasive intervention used in the management of tissue disorders. In this retrospective study, a total of 62 patients with actinic keratosis (AKs) were treated with surface illumination PDT. Comparisons with the clinical features, rate of recurrence as well as mali...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2016.04.017
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Photodynamic diagnosis (PDD) as well as thermovision belong to the category of non-invasive optical diagnosis techniques. Among many different skin cancer diseases, basal cell carcinoma (BCC) is the most frequently occurring one (almost 95% of all skin tumours). In contrast, seborrhoeic keratosis represents ...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2012.07.001
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Erosive oral lichen planus (EOLP) poses a substantial risk of malignant transformation into squamous cell cancer. The absence of established treatment gives way to alternative therapeutic strategies, including photodynamic therapy. The aim of the study was to evaluate the efficacy of PDT in the treatment of ...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2017.01.178
更新日期:2017-06-01 00:00:00
abstract::We report a case of idiopathic paracentral acute middle maculopathy with typical optical imaging and clinical features. A 26-year-old Chinese policeman presented with a 20-day history of paracentral scotoma in the left eye after early wake-up and long-time working in front of computer the day before. He experienced su...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2017.07.004
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:an accurate measurement of anterior chamber depth (ACD) both in eyes that underwent corneal refractive surgery (CRS) and in eyes that did not, can be crucial, as in case of intraocular lens (IOL) calculation in eyes that need to undergo cataract extraction, or during the evaluation of glaucomatous patients. ...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2020.101976
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The appearance of bacterial resistance to antibiotics a are major health problems. Antimicrobial photodynamic therapy (aPDT) has emerged as an adjunctive treatment for drug-resistant infections. Titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles have recently been proposed as effective carriers for p...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2020.101816
更新日期:2020-09-01 00:00:00
abstract:AIM:To assess the efficacy of phototherapy on bond strength and microleakage of bulk fill composites in comparison to conventional dentin surface treatments. MATERIALS AND METHODS:Ninety human third molars were divided into 3 groups (n = 30 each) according to surface conditioning treatment. Group 1 (Etch and Bond) EB,...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2018.12.014
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To examine the utility and safety of photodynamic diagnosis (PDD) after oral administration of 5-aminolevulinic acid (5-ALA) (ALA-PDD) of non-muscle-invasive bladder cancer (NMIBC) using fluorescent-light (FL)-cystoscopy. METHODS:The study was a single-arm, open-label, multi-center prospective study on ALA-P...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.pdpdt.2015.12.011
更新日期:2016-03-01 00:00:00
abstract::Glucose is the main energy substance to drive the physiological events of the cell.. Malignant cells exhibit a much higher rate of glycolysis than healthy cells to relieve the increased needs of energy. The higher metabolic rate induces the over-expression of the Glucose Transporter (GLUT) to transport more glucose in...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2020.102014
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Considering the important roles of porphyrins in biological systems and their promising use in photodynamic therapy (PDT), the present work investigated the photophysical properties of palladium(II) 5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrin (PdTSPP) and the effects of non-activated by light form of t...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2014.06.002
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Various techniques have been suggested to quantitatively assess tooth wear; most have limited clinical application. The first aim of this in vitro study was to estimate the residual enamel thickness of teeth with various degrees of occlusal wear using quantitative light-induced fluorescence (QLF). The second...
journal_title:Photodiagnosis and photodynamic therapy
pub_type: 杂志文章
doi:10.1016/j.pdpdt.2019.01.016
更新日期:2019-03-01 00:00:00