当前位置： SCI文献检索 > Photodiagnosis and Photodynamic Therapy期刊下所有文献 > Photodynamic therapy in the management of actinic keratosis: Retrospective evaluation of outcome.

Photodynamic therapy in the management of actinic keratosis: Retrospective evaluation of outcome.

Abstract：

INTRODUCTION:Photodynamic therapy (PDT) is a minimally invasive intervention used in the management of tissue disorders. In this retrospective study, a total of 62 patients with actinic keratosis (AKs) were treated with surface illumination PDT. Comparisons with the clinical features, rate of recurrence as well as malignant transformation and overall outcome were made. MATERIALS AND METHODS:The medical records of 62 consecutive patients who presented with suspicious skin lesions and diagnosed with AKs were examined. These patients with 178 AKs lesions were treated with surface illumination methyl aminolevulinate-photodynamic therapy (MAL-PDT). The 16% strength cream (MAL) was applied topically 3h prior to tissue illumination. A single-channel 628nm diode laser was used for illumination and light was delivered at 100J/cm2 per site. These patients were followed-up for a mean of 7.4 years. RESULTS:Eight recurrences were reported after the first round of MAL-PDT, and two recurrences after the second round. Malignant transformation to squamous cell carcinoma (SCC) was noted in 2 patients only. The 3-year outcome resulted in 60 patients with complete response (CR), and this was maintained at the final outcome (last clinic review). Assessment of lesional outcome vs. response showed that 175/178 treated lesions had complete response (CR) at 3-year follow-up, which increased to 176/178 lesions at the last clinic follow-up. CONCLUSION:MAL-PDT offers an effective treatment for AKs lesions with excellent cosmetic outcome.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Jerjes W,Hamdoon Z,Abdulkareem AA,Hopper C

doi

10.1016/j.pdpdt.2016.04.017

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

200-204

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(16)30048-5

journal_volume

17

pub_type

杂志文章

相关文献

Photodiagnosis and Photodynamic Therapy文献大全
  • Endoscopic photodynamic therapy for oesophageal disease.

    abstract：:Photodynamic therapy is a very important technique for the eradication of widespread oesophageal mucosal disease which has the potential to degenerate to cancer. Patients unsuitable or unwilling to undergo radical therapy can be cured using photodynamic therapy. We predominantly treat patients with high-grade dysplasi...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2006.03.008

    authors： Barr H,Kendall C,Bazant-Hegemark F,Stone N

    更新日期：2006-06-01 00:00:00

  • Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light.

    abstract：BACKGROUND:Autofluorescence bronchoscopy (AFB) is a highly sensitive tool for the detection of early bronchial cancers. However, its specificity remains limited due to primarily false positive results induced by hyperplasia, metaplasia and inflammation. We have investigated the potential of blue-violet backscattered li...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2008.01.005

    authors： Gabrecht T,Radu A,Grosjean P,Weber B,Reichle G,Freitag L,Monnier P,van den Bergh H,Wagnières G

    更新日期：2008-03-01 00:00:00

  • Photodynamic therapy (PDT) for lung cancer: the Yorkshire Laser Centre experience.

    abstract：BACKGROUND:The Yorkshire Laser Centre team have been engaged in photodynamic therapy (PDT) since 1990. In this article we review our experience in bronchoscopic PDT for lung cancer and outline our current indications and results. METHODS:160 patients in 2 groups entered into a prospective study: Group A (N=144) were s...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/S1572-1000(04)00047-X

    authors： Moghissi K,Dixon K,Thorpe JA,Oxtoby C,Stringer MR

    更新日期：2004-11-01 00:00:00

  • Conventional versus daylight photodynamic therapy for actinic keratosis: A randomized and prospective study in China.

    abstract：BACKGROUND:Conventional photodynamic therapy (C-PDT) is an effective treatment for actinic keratoses (AKs) in Asia, with some unmet needs. Severe PDT-associated pain results in low treatment willingness. Daylight photodynamic therapy (DL-PDT) is a more simple and tolerable treatment that has the same efficacy as C-PDT ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pdpdt.2018.10.010

    authors： Zhu L,Wang P,Zhang G,Zhang L,Liu X,Hu C,Yang X,Sroka R,Zhou Z,Wang X

    更新日期：2018-12-01 00:00:00

  • In vivo temporal evolution of ALA-induced normalized fluorescence at different anatomical locations of oral cavity: application to improve cancer diagnostic contrast and potential.

    abstract：BACKGROUND:The focal goal of this study is to identify optimal accumulation periods for ALA-induced PpIX in different healthy anatomical sites of human oral cavity and different types of abnormal mucosa to improve the accuracy of the clinical applications such as photodiagnosis and tissue grading. MATERIALS AND METHOD...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2010.06.006

    authors： Mallia RJ,Subhash N,Sebastian P,Kumar R,Thomas SS,Mathews A,Madhavan J

    更新日期：2010-09-01 00:00:00

  • Treatment of infected wounds with methylene blue photodynamic therapy: An effective and safe treatment method.

    abstract：BACKGROUND:Bacterial resistance is a problem during the process of healing of infected wounds. As a therapy, photodynamic therapy (PDT) has broad-spectral antibacterial activity and non-selective action, which makes it possible to deal with antibiotic resistance.. Methylene blue is a commonly used medicine, but it is r...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102051

    authors： Shen X,Dong L,He X,Zhao C,Zhang W,Li X,Lu Y

    更新日期：2020-12-01 00:00:00

  • Photophysical properties and in vitro photocytotoxicity of disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX (Dimegine).

    abstract：:Photophysical and in vitro photocytotoxicity studies were performed for the photosensitizer Dimegine, a disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX with very low systemic toxicity. The singlet oxygen and luminescence quantum yield were ΦΔ = 0,65 ± 0,06, and Φƒ=0,11 ± 0,01 respectively, and were indepe...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.11.006

    authors： Dadeko AV,Lilge L,Kaspler P,Murav'eva TD,Starodubtcev AM,Kiselev VM,Zarubaev VV,Ponomarev GV

    更新日期：2019-03-01 00:00:00

  • Manual dexterity and dental biofilm accumulation in independent older adults without hand disabilities: A cross-sectional study.

    abstract：BACKGROUND:This study investigated the relationship between manual dexterity and dental biofilm accumulation in independent older Koreans using Quantitative Light-Induced Fluorescence-Digital (QLF-D). METHODS:This cross-sectional study included 44 participants recruited from senior welfare facilities in South Korea an...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.pdpdt.2018.11.007

    authors： Shin NR,Choi JS

    更新日期：2019-03-01 00:00:00

  • The effectiveness of photodynamic and antibiotic gel therapy as an adjunct to mechanical debridement in the treatment of peri-implantitis among diabetic patients.

    abstract：AIM:The current clinical trial aimed to assess the effectiveness of adjunctive photodynamic therapy (aPDT) and adjunctive antibiotic gel therapy (aAGT) to treat peri-implantitis among patients with type 2 diabetes mellitus (T2DM). METHODS:Selected T2DM participants with peri-implantitis were distributed into 3 groups:...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102077

    authors： Ahmed P,Bukhari IA,Albaijan R,Sheikh SA,Vohra F

    更新日期：2020-12-01 00:00:00

  • Photoactivated resveratrol against Staphylococcus aureus infection in mice.

    abstract：BACKGROUND:Among the pathogens, Staphylococcus aureus is the main causative agent of bacterial diseases in the world. In this context, antimicrobial photodynamic therapy (aPDT) appears as a promising tool by means of microbial inactivation with the use of light. aPDT is applied in treatments involving photosensitizers ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.01.005

    authors： Dos Santos DP,Soares Lopes DP,de Moraes RC Junior,Vieira Gonçalves C,Pereira Rosa L,da Silva Rosa FC,da Silva RAA

    更新日期：2019-03-01 00:00:00

  • Influences of galactose ligand on the uptake of TADF liposomes by HepG2 cells.

    abstract：:Glucose is the main energy substance to drive the physiological events of the cell.. Malignant cells exhibit a much higher rate of glycolysis than healthy cells to relieve the increased needs of energy. The higher metabolic rate induces the over-expression of the Glucose Transporter (GLUT) to transport more glucose in...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102014

    authors： Wang C,Chen Z,Tang X,Liu X,Na W,Li W,Liu T

    更新日期：2020-12-01 00:00:00

  • Efficacy of lidocaine 7 %, tetracaine 7 % self-occlusive cream in reducing MAL-cPDT-associated pain in subjects with actinic keratosis: A randomized, single-blind, vehicle-controlled trial (The "3P-Trial").

    abstract：INTRODUCTION:Conventional photodynamic therapy (cPDT) is considered a very effective treatment of actinic keratosis (AK) lesions. However, its use is limited by the fact that this procedure could be very painful. The use of topical anesthetics such as tetracaine or lignocaine/prilocaine has shown disappointing results ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101758

    authors： Brumana MB,Milani M,Puviani M

    更新日期：2020-06-01 00:00:00

  • Ultraviolet radiation exposure during daylight Photodynamic Therapy.

    abstract：BACKGROUND:Daylight photodynamic therapy (dPDT) is an effective treatment for field-change actinic keratoses (AK), with similar efficacy to conventional PDT but lower patient pain scores. Whilst AK occur consequent to chronic solar ultraviolet (UV) exposure, paradoxically solar visible radiation is used during PDT. OB...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.05.020

    authors： McLellan LJ,O'Mahoney P,Khazova M,Higlett M,Ibbotson SH,Eadie E

    更新日期：2019-09-01 00:00:00

  • Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.

    abstract：BACKGROUND:Although aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy (PDT) is an effective FDA-approved therapy for actinic keratosis (AK), a substantial fraction of patients (up to 25%) do not respond to treatment. This study examined the feasibility of using pre-treatment measurements o...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pdpdt.2015.10.006

    authors： Kanick SC,Davis SC,Zhao Y,Sheehan KL,Hasan T,Maytin EV,Pogue BW,Chapman MS

    更新日期：2015-12-01 00:00:00

  • 5-aminolevulinic acid photodynamic therapy enhance the effect of acitretin on squamous cell carcinoma cells: An in vitro study.

    abstract：:Squamous cell carcinoma (SCC) remains the second most common nonmelanoma skin cancer (NMSC) worldwide. Both acitretin and 5-Aminolevulinic acid mediated photodynamic therapy (ALA-PDT) have validated effect on SCC. However, the effects of both treatmens remain limited, and there has been no report concerning the potent...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101887

    authors： Ye T,Jiang B,Chen B,Liu X,Yang L,Xiong W,Yu B

    更新日期：2020-09-01 00:00:00

  • Enhanced radiosensitivity of LNCaP prostate cancer cell line by gold-photoactive nanoparticles modified with folic acid.

    abstract：BACKGROUND:Conventional cancer treatment methods suffer from many limitations such as non-specificity in discrimination between healthy and malignant cells. The aim of this study was to investigate the role of polymeric gold-photoactive nanoparticles (PGPNPs) conjugated with folic acid (FA) as theranostic nanoparticles...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.101602

    authors： Changizi O,Khoei S,Mahdavian A,Shirvalilou S,Mahdavi SR,Keyvan Rad J

    更新日期：2020-03-01 00:00:00

  • Antimicrobial Photodynamic Therapy with the photosensitizer TONS504 eradicates Acanthamoeba.

    abstract：BACKGROUND:Microbial keratitis is a potential cause of corneal blindness. We investigated the amoebicidal efficacy of photodynamic antimicrobial therapy with a light-emitting diode as the light source and the cationic chlorin derivative TONS504 as the photosensitizer for the elimination of Acanthamoeba, a causative org...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.08.035

    authors： Pertiwi YD,Chikama T,Sueoka K,Ko JA,Kiuchi Y,Onodera M,Sakaguchi T

    更新日期：2019-12-01 00:00:00

  • Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma.

    abstract：BACKGROUND:Early diagnosis of non-melanoma skin cancer (NMSC) is potentially possible using optical coherence tomography (OCT) which provides non-invasive, real-time images of skin with micrometre resolution and an imaging depth of up to 2mm. OCT technology for skin imaging has undergone significant developments, impro...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.08.004

    authors： Olsen J,Themstrup L,De Carvalho N,Mogensen M,Pellacani G,Jemec GB

    更新日期：2016-12-01 00:00:00

  • Anticancer effect of LS-HB-mediated photodynamic therapy on hepatocellular carcinoma in vitro and in vivo.

    abstract：:Photodynamic therapy (PDT) is a relatively safe way for disease diagnosis and treatment that is based on light and photosensitizers. LS-HB is a promising photosensitizer with a light absorption peak of 660 nm. AIMS:The present study aimed to investigate the anticancer effects of LS-HB-PDT on hepatocellular carcinoma ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101718

    authors： Liu C,Wu T,Wang S,Zhou W,Li Y,Chen X,Li W,Huang Z,Li T,Yang L,Xu P,Liuzong J,Xie J,Yang D,Yan J,Luo F

    更新日期：2020-06-01 00:00:00

  • Raman spectroscopy combined with multiple algorithms for analysis and rapid screening of chronic renal failure.

    abstract：:Chronic renal failure (CRF) is a symptom of kidney damage in the terminal stages. If a patient is not treated, then CRF will progress to uremia, which greatly reduces the lifespan of the patient. However, current screening strategies, including routine urine tests and medical imaging investigations, have poor sensitiv...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101792

    authors： Chen C,Yang L,Li H,Chen F,Chen C,Gao R,Lv XY,Tang J

    更新日期：2020-06-01 00:00:00

  • Effect of Photofrin-mediated photocytotoxicity on a panel of human pancreatic cancer cells.

    abstract：BACKGROUND AND OBJECTIVE:Pancreatic cancer is a leading cause of cancer-related deaths in men and women. Early clinical studies suggest that photodynamic therapy (PDT) might be a useful modality in the management of this deadly disease. In this study, the photocytotoxicity of Photofrin-mediated PDT on different human p...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.11.001

    authors： Wang LW,Huang Z,Lin H,Li ZS,Hetzel F,Liu Md B

    更新日期：2013-09-01 00:00:00

  • Optical coherence tomography in the diagnosis of actinic keratosis-A systematic review.

    abstract：BACKGROUND:Optical coherence tomography (OCT) is a real-time non-invasive imaging tool, introduced in dermatology in the late 1990s. OCT uses near-infrared light impulses to produce images which can be displayed in cross-sectional and en-face mode. The technique has been used to image skin diseases especially non-melan...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,评审

    doi：10.1016/j.pdpdt.2017.02.003

    authors： Friis KBE,Themstrup L,Jemec GBE

    更新日期：2017-06-01 00:00:00

  • In vitro assessment of anti-tumorigenic mechanisms and efficacy of NanoALA, a nanoformulation of aminolevulic acid designed for photodynamic therapy of cancer.

    abstract：BACKGROUND:The development of nanocarriers is an important approach to increase the bioavailability of hydrophilic drugs in target cells. In this work, we evaluated the anti-tumorigenic mechanisms and efficacy of NanoALA, a novel nanoformulation of aminolevulic acid (ALA) based on poly(lactide-co-glycolide) (PLGA) nano...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2017.08.011

    authors： de Andrade LR,Primo FL,da Silva JR,Tedesco AC,Lacava ZGM

    更新日期：2017-12-01 00:00:00

  • Long-term Improvement on Photoaging After ALA Photodynamic Therapy for Actinic Keratosis: A Retrospective Study.

    abstract：BACKGROUND:5-aminolevulinic acid photodynamic therapy (ALA-PDT) is not only the first-line treatment for actinic keratosis (AK), but also demonstrated to improve photoaging during AK field treatment. However, its long-term improvement effect on photoaging remains elusive. OBJECTIVE:To evaluate the long-term improvemen...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2021.102181

    authors： Zhang L,Zhao Z,Wang P,Zhang G,Wang B,Shi L,Liu X,Zhou Z,Wang X

    更新日期：2021-01-08 00:00:00

  • Combination of tacalcitol ointment and photodynamic therapy for the treatment of follicular mucinosis of the scalp.

    abstract：:Follicular mucinosis (FM) is a rare inflammatory disorder histologically characterized by mucin deposition in the follicular epithelium. There is no standard therapy for FM and several treatments have been described in the literature. We present the case of a 59 year-old female affected by a recalcitrant FM with diffu...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.07.003

    authors： Giuffrida R,Borgia F,Marafioti I,Riso G,Cannavò SP

    更新日期：2019-09-01 00:00:00

  • Enhancement of blood porphyrin emission intensity with aminolevulinic acid administration: a new concept for photodynamic diagnosis of early prostate cancer.

    abstract：BACKGROUND:The objective of this paper was to verify if the oral administration of δ-aminolevulinic acid (ALA) in animals with prostate tumor can increase the sensitivity of cancer diagnosis by protoporphyrin IX blood autofluorescence. In this study, the autofluorescence of blood porphyrin was analyzed using fluorescen...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2010.12.006

    authors： Silva FR,Bellini MH,Nabeshima CT,Schor N,Vieira ND Jr,Courrol LC

    更新日期：2011-03-01 00:00:00

  • The effect of light fractionation with a 2-h dark interval on the efficacy of topical hexyl-aminolevulinate photodynamic therapy in normal mouse skin.

    abstract：BACKGROUND:Light fractionation with a 2-h dark interval increases the efficacy of topical aminolevulinic acid (ALA) photodynamic therapy (PDT). Hexyl-aminolevulinate (HAL) is the hexyl ester of ALA. Both HAL and ALA lead to protoporphyrin IX (PpIX) accumulation in endothelial cells and to vascular effects, which are im...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2013.09.002

    authors： Middelburg TA,de Bruijn HS,van der Ploeg-van den Heuvel A,Neumann HA,Robinson DJ

    更新日期：2013-12-01 00:00:00

  • The optical imaging of idiopathic paracentral acute middle maculopathy in a Chinese young man and review of the literature.

    abstract：:We report a case of idiopathic paracentral acute middle maculopathy with typical optical imaging and clinical features. A 26-year-old Chinese policeman presented with a 20-day history of paracentral scotoma in the left eye after early wake-up and long-time working in front of computer the day before. He experienced su...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2017.07.004

    authors： Chen Y,Hu Y

    更新日期：2017-09-01 00:00:00

  • Evaluation of ALA-PDT combined with antibiotics for the treatment of skin ulcers with sinus tract formation: A pilot study.

    abstract：BACKGROUND:Photodynamic therapy (PDT) is considered an important and innovative treatment for healing skin wounds. Skin ulcers with sinus tract formation are rare and difficult to treat in the field of dermatology. Herein, we utilized optical fibers as a light source to penetrate the sinus tract and applied PDT to trea...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101802

    authors： Tan Y,Bai Y,Li F,Chen J,Cheng Q,Wang J,Li J,Lei X

    更新日期：2020-09-01 00:00:00

  • Evaluation of tooth wear by estimating enamel thickness with quantitative light-induced fluorescence technology.

    abstract：BACKGROUND:Various techniques have been suggested to quantitatively assess tooth wear; most have limited clinical application. The first aim of this in vitro study was to estimate the residual enamel thickness of teeth with various degrees of occlusal wear using quantitative light-induced fluorescence (QLF). The second...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.01.016

    authors： Kim SK,Park SW,Lee HS,Lee ES,de Josselin de Jong E,Kim BI

    更新日期：2019-03-01 00:00:00