当前位置： SCI文献检索 > Photodiagnosis and Photodynamic Therapy期刊下所有文献 > 5-aminolevulinic acid photodynamic therapy enhance the effect of acitretin on squamous cell carcinoma cells: An in vitro study.

5-aminolevulinic acid photodynamic therapy enhance the effect of acitretin on squamous cell carcinoma cells: An in vitro study.

Abstract：

:Squamous cell carcinoma (SCC) remains the second most common nonmelanoma skin cancer (NMSC) worldwide. Both acitretin and 5-Aminolevulinic acid mediated photodynamic therapy (ALA-PDT) have validated effect on SCC. However, the effects of both treatmens remain limited, and there has been no report concerning the potential synergistic effect of both treatments for SCC. OBJECTIVE:To investigate the cytotoxic effect of acitretin on SCL-1 cells, and whether ALA-PDT enhances this effect. METHODS:CCK-8 and trypan blue exclusion array were used to detect the cell cytotoxicity after acitretin treatment with different concentrations (1.6 × 10-4mg/mL, 1.6 × 10-3 mg/mL, 1.6 × 10-2mg/mL and 1.6 × 10-1mg/mL) for 24 h, 48 h and 72 h. Flow cytometry and trypan blue exclusion assay were used to detect the apoptosis and viability of SCL-1 cells after treated with acitretin, ALA-PDT and ALA-PDT immediately followed by acitretin. Independent sample t test was used to analyze the different incubation time of acitretin and acitretin combined with ALA-PDT on SCL-1 cells. Bonferroni Test One-way Anova method was used to analyze the effect of different treatment on the SCL-1 cells. RESULTS:A significant cytotoxic effect was observed after acitretin treatment, in an acitretin concentration-dependent manner within the range of 1.6 × 10-4mg/mL to 1.6 × 10-1mg/mL and an acitretin incubation time-dependent manner within 24 h-72 h. The total apoptosis rate and dead cells rate in group of ALA-PDT combined with acitretin were both significantly higher than that of acitretin, ALA-PDT group. A stronger apoptotic and cytotoxic effect detected 24 h after treated with acitretin than that of 12 h was observed in this study. CONCLUSION:Acitretin has a cytotoxic effect on SCL-1 cells, and ALA-PDT treatment enhances the the cytotoxic effect of acitretin.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Ye T,Jiang B,Chen B,Liu X,Yang L,Xiong W,Yu B

doi

10.1016/j.pdpdt.2020.101887

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

101887

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(20)30241-6

journal_volume

31

pub_type

杂志文章

相关文献

Photodiagnosis and Photodynamic Therapy文献大全
  • Photodynamic inactivation mediated by methylene blue or chlorin e6 against Streptococcus mutans biofilm.

    abstract：BACKGROUND:An appropriate photosensitizer (PS) for photodynamic inactivation should have a pronounced antimicrobial efficacy but low dark toxicity. The aim of this study is to investigate the concentration-dependent antimicrobial efficacies of methylene blue (MB) and chlorin e6 (Ce6), against Streptococcus mutans biofi...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101817

    authors： Nie M,Deng DM,Wu Y,de Oliveira KT,Bagnato VS,Crielaard W,Rastelli ANS

    更新日期：2020-09-01 00:00:00

  • Photodynamic effect of curcumin on Vibrio parahaemolyticus.

    abstract：:Vibrio parahaemolyticus (V. parahaemolyticus) is currently a major cause of bacterial diarrhoea associated with seafood consumption. The objective of this study was to determine the inactivation effect of curcumin-mediated photodynamic action on V. parahaemolyticus. First of all, V. parahaemolyticus suspended in PBS b...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.05.004

    authors： Wu J,Mou H,Xue C,Leung AW,Xu C,Tang QJ

    更新日期：2016-09-01 00:00:00

  • Effect of Er,Cr:YSGG on bond strength and microleakage of dentin bonded to resin composite with different distance and irradiation time.

    abstract：BACKGROUND:To explore the surface modification of dentin using Er,Cr:YSGG phototherapy and bonding system on the shear bond strength and microleakage scores at two different distances and times of laser irradiation. MATERIALS AND METHODS:Ninety disease-free third molars were collected for the experiment. The four lase...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.10.017

    authors： Almojaly SA,Sulaiman Al-Hamdan R,Alrahlah A,Qutub OA,Alnajashi S,Vohra F,Abduljabbar T

    更新日期：2019-03-01 00:00:00

  • Does the temperature gradient correlate with the photodynamic diagnosis parameter numerical colour value (NCV)?

    abstract：BACKGROUND:Photodynamic diagnosis (PDD) as well as thermovision belong to the category of non-invasive optical diagnosis techniques. Among many different skin cancer diseases, basal cell carcinoma (BCC) is the most frequently occurring one (almost 95% of all skin tumours). In contrast, seborrhoeic keratosis represents ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.07.001

    authors： Cholewka A,Stanek A,Kwiatek S,Sieroń A,Drzazga Z

    更新日期：2013-02-01 00:00:00

  • Temperature effect on the PpIX production during the use of topical precursors.

    abstract：:Decreasing incubation time, as well as enhanced PpIX production, are present challenges for topical photodynamic therapy (PDT). There are reports concerning the existence of a strong relationship between site temperature and porphyrin synthesis in biological tissue, that suggest temperature increase in the tissue can ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101786

    authors： Stringasci MD,Moriyama LT,Vollet-Filho JD,Bagnato VS

    更新日期：2020-06-01 00:00:00

  • Photodynamic therapy of vulvar lichen sclerosus et atrophicus in a woman with hypothyreosis--case report.

    abstract：:Lichen sclerosus et atrophicus (LSA) is disease of skin and mucosa, its pathogenesis remains unknown. Itching, pain and burning sensations and atrophy of vulva impair quality of life. Treatment is symptomatic. We report case of 30-year old woman with lesions in vulva in which series of topical PDT were carried out. We...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.02.002

    authors： Osiecka BJ,Nockowski P,Jurczyszyn K,Ziólkowski P

    更新日期：2012-06-01 00:00:00

  • Photodynamic therapy in China: Over 25 years of unique clinical experience Part One-History and domestic photosensitizers.

    abstract：:Photodynamic therapy (PDT) was started in the People's Republic of China in the early 1980s after domestically produced hematoporphyrin derivative (HpD) became available. Since then, numerous photosensitizers have been synthesized and evaluated. Several promising ones have undergone clinical investigations and a few h...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/S1572-1000(06)00009-3

    authors： Huang Z

    更新日期：2006-03-01 00:00:00

  • The effect of indocyanine green-based photodynamic therapy on healthy fibroblast and keratinocyte cells.

    abstract：BACKGROUND:Photodynamic therapy is a promising invention to treat infections and cancer where conventional treatments are insufficient and have many side effects. Photodynamic therapy is mainly emphasized as having minimal side effects on healthy cells during local applications, even so photosensitizer can accumulate i...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101891

    authors： Topaloğlu N,Kadıköylü G,Onak G,Karaman O

    更新日期：2020-09-01 00:00:00

  • Single treatment of low-risk basal cell carcinomas with pulsed dye laser-mediated photodynamic therapy (PDL-PDT) compared with photodynamic therapy (PDT): A controlled, investigator-blinded, intra-individual prospective study.

    abstract：BACKGROUND AND OBJECTIVE:To compare a single treatment of PDL-PDT with PDT for BCCs in terms of efficacy, aesthetic outcome, and pain in patients with multiple BCCs. STUDY DESIGN/MATERIALS AND METHODS:A prospective, controlled, intra-individual, investigator-blinded study was conducted on 15 patients with 62 BCCs. The...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.08.003

    authors： Čarija A,Puizina-Ivić N,Vuković D,Mirić Kovačević L,Čapkun V

    更新日期：2016-12-01 00:00:00

  • The role of anti-apoptotic protein kinase Cα in response to hypericin photodynamic therapy in U-87 MG cells.

    abstract：:Hypericin photodynamic therapy (HypPDT) has been found to be an efficient inducer of cell death. However, there are indications that HypPDT also activates rescuing pathways. Cell responses to HypPDT are highly dependent on the Hyp intracellular localization and accumulation. We have shown previously that in U87 MG cel...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2014.02.010

    authors： Dzurová L,Petrovajova D,Nadova Z,Huntosova V,Miskovsky P,Stroffekova K

    更新日期：2014-06-01 00:00:00

  • Photobiomodulation and antimicrobial photodynamic therapy for oral cytomegalovirus reactivation following acute graft-versus-host disease.

    abstract：:The relationship between cytomegalovirus (CMV), a severe complication in immunocompromised patients, and graft-versus-host disease (GVHD) has already been reported but remains without complete elucidation, especially concerning oral lesions. Considering that antimicrobial photodynamic therapy (aPDT) has an antimicrobi...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101849

    authors： Rezende SB,Campos L,Palma LF,Tateno RY,Simões A,Macedo MC,Silva RLD

    更新日期：2020-12-01 00:00:00

  • The role of optical coherence tomography angiography in reticular pseudodrusen.

    abstract：BACKGROUND:To investigate the changes in retinal and choriocapillaris vessel density (VD) in patients affected by early age-related macular degeneration (AMD) and reticular pseudodrusen (RPD), using Optical Coherence Tomography Angiography (OCTA). METHODS:A total of seventy-eight eyes of 78 patients (43 male, 35 femal...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102094

    authors： Montorio D,D'Andrea L,Mirto N,Cennamo G

    更新日期：2020-11-11 00:00:00

  • Clinical analysis of color change and tooth sensitivity to violet LED during bleaching treatment: A case series with split-mouth design.

    abstract：BACKGROUND:The aim of this study was to analyze bleaching treatment performed with different products, with or without the use of Violet LED. METHODS:The color and dental sensitivity of six patients were evaluated as follows: (1)at-home bleaching with 10% Carbamide Peroxide (CP); (2)in-office bleaching with 17.5% Hydr...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.05.016

    authors： Gallinari MO,Cintra LTA,Souza MBA,Barboza ACS,Esteves LMB,Fagundes TC,Briso ALF

    更新日期：2019-09-01 00:00:00

  • Interference with the Jaffé method for creatinine following 5-aminolevulinic acid administration.

    abstract：BACKGROUND:The photosensitizer pro-drug 5-aminolevulinic acid (5-ALA) has been administered systemically for photodynamic therapy. Although several toxicities have been reported, nephrotoxicity has never been observed. MATERIALS AND METHODS:Patients with head and neck mucosal dysplasia have been treated on a phase 1 s...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2010.07.008

    authors： Quon H,Grossman CE,King RL,Putt M,Donaldson K,Kricka L,Finlay J,Zhu T,Dimofte A,Malloy K,Cengel KA,Busch TM

    更新日期：2010-12-01 00:00:00

  • PDT induced bystander effect on human xenografted colorectal tumors as evidenced by sodium MRI.

    abstract：BACKGROUND:Previous in vivo studies on photodynamic therapy (PDT)-treated, high cellular density tumors showed evidences of a bystander effect accompanying the therapy, cellular death continuing beyond the limits of the photochemical reactions in time and space. This process is generated by the initially damaged cells ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.03.001

    authors： Poyer F,Thomas CD,Garcia G,Croisy A,Carrez D,Maillard P,Lupu M,Mispelter J

    更新日期：2012-12-01 00:00:00

  • Influence of ALA-mediated photodynamic therapy on secretion of interleukins 6, 8 and 10 by colon cancer cells in vitro.

    abstract：BACKGROUND:Photodynamic therapy has apart from a direct cytotoxic effect also immunomodulatory properties. The aim of our study was to investigate how photodynamic therapy with 5-aminolevulinic acid (ALA-PDT) in sublethal doses influences the secretion of interleukins 6, 8 and 10 from colon cancer cells in vitro. METH...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.02.021

    authors： Kawczyk-Krupka A,Czuba Z,Latos W,Wasilewska K,Verwanger T,Krammer B,Sieroń A

    更新日期：2018-06-01 00:00:00

  • Photodiagnosis and treatment of condyloma acuminatum using 5-aminolevulinic acid and homemade devices.

    abstract：BACKGROUND:The objective of this study was to improve the feasibility of applying topic 5-aminolevulinic acid (ALA) in photodiagnosis (PD) and treatment of condyloma caused by human papillomavirus (HPV) using two homemade handheld devices and to discuss the photodynamic therapy (PDT) as a suitable alternative for each ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pdpdt.2011.09.001

    authors： Inada NM,Costa MM,Guimarães OC,Ribeiro Eda S,Kurachi C,Quintana SM,Lombardi W,Bagnato VS

    更新日期：2012-03-01 00:00:00

  • An investigation of the fluorescence induced by topical application of 5-aminolaevulinic acid and methyl aminolaevulinate at different body sites on normal human skin.

    abstract：BACKGROUND:Although discovered over a century ago it is only in the last 25 years that photodynamic therapy (PDT) has been the focus of intense research. This versatile treatment modality has been shown to be effective in treating a wide variety of malignancies, and with the increasing incidence of non-melanoma skin ca...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2010.12.004

    authors： Lesar A,Ferguson J,Moseley H

    更新日期：2011-06-01 00:00:00

  • In vitro photodynamic inactivation of Candida species and mouse fibroblasts with phenothiazinium photosensitisers and red light.

    abstract：:In the present study, the in vitro susceptibilities of five Candida spp. to photodynamic antimicrobial chemotherapy (PACT) with four phenothiazinium derivatives, methylene blue (MB), new methylene blue N (NMBN), toluidine blue O (TBO) and the novel pentacyclic phenothiazinium photosensitiser S137, in combination with ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.11.004

    authors： Rodrigues GB,Dias-Baruffi M,Holman N,Wainwright M,Braga GU

    更新日期：2013-05-01 00:00:00

  • Efficacy of lidocaine 7 %, tetracaine 7 % self-occlusive cream in reducing MAL-cPDT-associated pain in subjects with actinic keratosis: A randomized, single-blind, vehicle-controlled trial (The "3P-Trial").

    abstract：INTRODUCTION:Conventional photodynamic therapy (cPDT) is considered a very effective treatment of actinic keratosis (AK) lesions. However, its use is limited by the fact that this procedure could be very painful. The use of topical anesthetics such as tetracaine or lignocaine/prilocaine has shown disappointing results ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101758

    authors： Brumana MB,Milani M,Puviani M

    更新日期：2020-06-01 00:00:00

  • Photodynamic therapy combined with surgery for hidradenitis suppurativa: A case report.

    abstract：:Hidradenitis Suppurativa (HS) is a distressing painful chronic inflammatory skin follicular condition. It is a challenge to achieve better therapeutic effect and lower recurrence rate. In this report, ALA-PDT combined with surgery for the treatment achieved ulcer healing, pain elimination, with no relapse during our f...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.07.024

    authors： Luo D,Tan Y,Cheng Q,Wu J,Lei X

    更新日期：2019-12-01 00:00:00

  • Photophysical properties and in vitro photocytotoxicity of disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX (Dimegine).

    abstract：:Photophysical and in vitro photocytotoxicity studies were performed for the photosensitizer Dimegine, a disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX with very low systemic toxicity. The singlet oxygen and luminescence quantum yield were ΦΔ = 0,65 ± 0,06, and Φƒ=0,11 ± 0,01 respectively, and were indepe...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.11.006

    authors： Dadeko AV,Lilge L,Kaspler P,Murav'eva TD,Starodubtcev AM,Kiselev VM,Zarubaev VV,Ponomarev GV

    更新日期：2019-03-01 00:00:00

  • Comparison between the outcomes of fluorescein angiography-guided and indocyanine green angiography-guided half-time photodynamic therapy for central serous chorioretinopathy.

    abstract：BACKGROUND AND OBJECTIVES:This study aimed to compare the efficacy of fluorescein angiography (FA)-guided and indocyanine green angiography (ICGA)-guided half-time photodynamic therapy (PDT) for central serous chorioretinopathy (CSC). SUBJECTS AND METHODS:Medical records of 61 eyes of 61 CSC patients who underwent hal...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101955

    authors： Hayashida M,Miki A,Honda S,Nakamura M

    更新日期：2020-09-01 00:00:00

  • Raman spectroscopy combined with multiple algorithms for analysis and rapid screening of chronic renal failure.

    abstract：:Chronic renal failure (CRF) is a symptom of kidney damage in the terminal stages. If a patient is not treated, then CRF will progress to uremia, which greatly reduces the lifespan of the patient. However, current screening strategies, including routine urine tests and medical imaging investigations, have poor sensitiv...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101792

    authors： Chen C,Yang L,Li H,Chen F,Chen C,Gao R,Lv XY,Tang J

    更新日期：2020-06-01 00:00:00

  • Photodynamic therapy enhances skin cancer chemotherapy effects through autophagy regulation.

    abstract：:Non-melanotic cutaneous cancers and melanoma are the main common type skin cancers worldwide. Despite many therapeutic options, therapeutic efficacy is not satisfied in all patients with advanced skin cancers, especially in melanoma. Photodynamic therapy (PDT) is a technology for skin disease treatment because of its ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.08.023

    authors： Zhang L,Ji Z,Zhang J,Yang S

    更新日期：2019-12-01 00:00:00

  • Influences of galactose ligand on the uptake of TADF liposomes by HepG2 cells.

    abstract：:Glucose is the main energy substance to drive the physiological events of the cell.. Malignant cells exhibit a much higher rate of glycolysis than healthy cells to relieve the increased needs of energy. The higher metabolic rate induces the over-expression of the Glucose Transporter (GLUT) to transport more glucose in...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102014

    authors： Wang C,Chen Z,Tang X,Liu X,Na W,Li W,Liu T

    更新日期：2020-12-01 00:00:00

  • Effect of Photofrin-mediated photocytotoxicity on a panel of human pancreatic cancer cells.

    abstract：BACKGROUND AND OBJECTIVE:Pancreatic cancer is a leading cause of cancer-related deaths in men and women. Early clinical studies suggest that photodynamic therapy (PDT) might be a useful modality in the management of this deadly disease. In this study, the photocytotoxicity of Photofrin-mediated PDT on different human p...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.11.001

    authors： Wang LW,Huang Z,Lin H,Li ZS,Hetzel F,Liu Md B

    更新日期：2013-09-01 00:00:00

  • Porfimer sodium photodynamic therapy in the treatment of early oesophageal carcinoma.

    abstract：BACKGROUND:The gold standard treatment of early oesophageal carcinoma is oesophagectomy but the elderly population affected are often medically unfit for this radical intervention and less invasive curative options are required. We describe our experience of porfimer sodium photodynamic therapy (PDT) as an alternative ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2007.09.003

    authors： Craig C,Gray J,Macpherson M,Hodgson H,Zammit M,Fullarton G

    更新日期：2007-12-01 00:00:00

  • Pulse mode of laser photodynamic treatment induced cell apoptosis.

    abstract：:One of the factors limiting photodynamic therapy (PDT) is hypoxia in tumor cells during photodynamic action. PDT with pulse mode irradiation and appropriate irradiation parameters could be more effective in the singlet oxygen generation and tissue re-oxygenation than continuous wave (CW) mode. We theoretically demonst...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.01.003

    authors： Klimenko VV,Knyazev NA,Moiseenko FV,Rusanov AA,Bogdanov AA,Dubina MV

    更新日期：2016-03-01 00:00:00

  • The effectiveness of photodynamic and antibiotic gel therapy as an adjunct to mechanical debridement in the treatment of peri-implantitis among diabetic patients.

    abstract：AIM:The current clinical trial aimed to assess the effectiveness of adjunctive photodynamic therapy (aPDT) and adjunctive antibiotic gel therapy (aAGT) to treat peri-implantitis among patients with type 2 diabetes mellitus (T2DM). METHODS:Selected T2DM participants with peri-implantitis were distributed into 3 groups:...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102077

    authors： Ahmed P,Bukhari IA,Albaijan R,Sheikh SA,Vohra F

    更新日期：2020-12-01 00:00:00