当前位置： SCI文献检索 > Photodiagnosis and Photodynamic Therapy期刊下所有文献 > An investigation of the fluorescence induced by topical application of 5-aminolaevulinic acid and methyl aminolaevulinate at different body sites on normal human skin.

An investigation of the fluorescence induced by topical application of 5-aminolaevulinic acid and methyl aminolaevulinate at different body sites on normal human skin.

Abstract：

BACKGROUND:Although discovered over a century ago it is only in the last 25 years that photodynamic therapy (PDT) has been the focus of intense research. This versatile treatment modality has been shown to be effective in treating a wide variety of malignancies, and with the increasing incidence of non-melanoma skin cancer (NMSC) is a recognised treatment in dermatology clinics worldwide. There is little known as to whether different body sites influence the uptake and conversion of 5-aminolaevulinic acid (ALA) or methyl aminolaevulinate (MAL) to protoporphyrin IX (PpIX). In this study we investigated the characteristics of PpIX fluorescence within normal skin following the application of both ALA and MAL to four different body sites and the effect of tape stripping. METHODS:A total of 17 healthy volunteers were recruited, and both ALA and MAL were applied to the inner forearm, outer forearm, lower leg and back for 4h. PpIX fluorescence was detected using a non-invasive spectroscopy system. RESULTS AND CONCLUSIONS:PpIX fluorescence (following the application of either ALA or MAL) does vary significantly at different body sites with the lower leg producing the least. Following the application of ALA, peak fluorescence was noted at all body sites at 24h, except the lower leg, which peaked at 7h. In contrast MAL induced fluorescence at all body sites, peaked earlier at 7h and had significantly decreased by 24h. Removal of the stratum corneum by tape stripping was also shown to significantly increase PpIX fluorescence but did not alter the time course.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Lesar A,Ferguson J,Moseley H

doi

10.1016/j.pdpdt.2010.12.004

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

97-103

issue

2

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(10)00146-8

journal_volume

8

pub_type

杂志文章

相关文献

Photodiagnosis and Photodynamic Therapy文献大全
  • Protoporphyrinogen oxidase is involved in the fluorescence intensity of 5-aminolevulinic acid-mediated laser-based photodynamic endoscopic diagnosis for early gastric cancer.

    abstract：BACKGROUND/AIM:Laser-based photodynamic endoscopic diagnosis (LPDED) is a type of endoscopic diagnosis that uses the fluorescence caused by the photochemical reaction that occurs when a fluorescent substance is irradiated by a light of a specific wavelength. Although 5-aminolevulinic acid (5-ALA) can detect early gastr...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.02.005

    authors： Kurumi H,Kanda T,Kawaguchi K,Yashima K,Koda H,Ogihara K,Matsushima K,Nakao K,Saito H,Fujiwara Y,Osaki M,Okada F,Isomoto H

    更新日期：2018-06-01 00:00:00

  • In vitro photodynamic inactivation of Candida species and mouse fibroblasts with phenothiazinium photosensitisers and red light.

    abstract：:In the present study, the in vitro susceptibilities of five Candida spp. to photodynamic antimicrobial chemotherapy (PACT) with four phenothiazinium derivatives, methylene blue (MB), new methylene blue N (NMBN), toluidine blue O (TBO) and the novel pentacyclic phenothiazinium photosensitiser S137, in combination with ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.11.004

    authors： Rodrigues GB,Dias-Baruffi M,Holman N,Wainwright M,Braga GU

    更新日期：2013-05-01 00:00:00

  • Clinical efficacy of photodynamic therapy as an adjunct to mechanical debridement in the treatment of per-implantitis with abscess.

    abstract：AIM:The aim of the present clinical trial was to evaluate the efficacy of photodynamic therapy (PDT) as an adjunct to mechanical debridement (MD) in the treatment of severe peri-implantitis (PI) with abscess. MATERIALS AND METHODS:Selected individuals with severe PI were divided into two groups: Group A: received meth...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101750

    authors： Almohareb T,Alhamoudi N,Al Deeb M,Bin-Shuwaish MS,Mokeem SA,Saad Shafqat S,Vohra F,Abduljabbar T

    更新日期：2020-06-01 00:00:00

  • Effect of Er,Cr:YSGG on bond strength and microleakage of dentin bonded to resin composite with different distance and irradiation time.

    abstract：BACKGROUND:To explore the surface modification of dentin using Er,Cr:YSGG phototherapy and bonding system on the shear bond strength and microleakage scores at two different distances and times of laser irradiation. MATERIALS AND METHODS:Ninety disease-free third molars were collected for the experiment. The four lase...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.10.017

    authors： Almojaly SA,Sulaiman Al-Hamdan R,Alrahlah A,Qutub OA,Alnajashi S,Vohra F,Abduljabbar T

    更新日期：2019-03-01 00:00:00

  • Successful treatment for multiple Bowen's disease using photodynamic therapy: A case report.

    abstract：:Bowen's disease, also named squamous cell carcinoma in situ, is usually treated by surgical excision. However, surgery is not suitable to patients with large area of lesions, multiple lesions or in cosmetically important areas where a scar will be visible. Photodynamic therapy (PDT) has advantages of efficacy, safety,...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type：

    doi：10.1016/j.pdpdt.2020.101783

    authors： Wu MF,Lv T,Wang HW

    更新日期：2020-06-01 00:00:00

  • Influence of ultrasonic activation over final irrigants in the removal of photosensitizer from root canal walls after photodynamic therapy.

    abstract：INTRODUCTION:The aim of the present study was to evaluate the influence of ultrasonic activation (US) of the final irrigant in the removal of the photosensitizer from root canal walls after photodynamic therapy. METHODS:The root canals of 60 single-rooted bovine extracted teeth were filled with 0.01% methylene blue an...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.12.011

    authors： Souza MA,Pazinatto B,Bischoff KF,Palhano HS,Cecchin D,de Figueiredo JAP

    更新日期：2017-03-01 00:00:00

  • Cure of condyloma acuminata covering the glans penis using aminolevulinic acid/photodynamic therapy.

    abstract：:Condyloma acuminata are a type of verrucous hyperplasia in the genital and perianal areas caused by human papilloma virus (HPV) infection. Traditional treatment methods for condyloma acuminata, such as topical medications, carbon dioxide (CO2) laser, cryotherapy, and surgical excision, can be effective at removing war...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type：

    doi：10.1016/j.pdpdt.2020.101658

    authors： Yin G,Zhang Y,Geng M,Cai B,Zheng Y

    更新日期：2020-06-01 00:00:00

  • Autofluorescence spectroscopy for NADH and flavoproteins redox state monitoring in the isolated rat heart subjected to ischemia-reperfusion.

    abstract：BACKGROUND:Reduction of myocardial ischemia-reperfusion injury in the patients undergoing cardiac surgery under cardiopulmonary bypass represents an important goal. Intraoperative monitoring of myocardial metabolic state using continuous registration of nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucl...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2014.05.003

    authors： Papayan G,Petrishchev N,Galagudza M

    更新日期：2014-09-01 00:00:00

  • Photodynamic therapy for cancer: Role of natural products.

    abstract：:Photodynamic therapy (PDT) is a promising modality for the treatment of cancer. PDT involves administering a photosensitizing dye, i.e. photosensitizer, that selectively accumulates in tumors, and shining a light source on the lesion with a wavelength matching the absorption spectrum of the photosensitizer, that exert...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,评审

    doi：10.1016/j.pdpdt.2019.04.033

    authors： Mansoori B,Mohammadi A,Amin Doustvandi M,Mohammadnejad F,Kamari F,Gjerstorff MF,Baradaran B,Hamblin MR

    更新日期：2019-06-01 00:00:00

  • Photodiagnosis and treatment of condyloma acuminatum using 5-aminolevulinic acid and homemade devices.

    abstract：BACKGROUND:The objective of this study was to improve the feasibility of applying topic 5-aminolevulinic acid (ALA) in photodiagnosis (PD) and treatment of condyloma caused by human papillomavirus (HPV) using two homemade handheld devices and to discuss the photodynamic therapy (PDT) as a suitable alternative for each ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pdpdt.2011.09.001

    authors： Inada NM,Costa MM,Guimarães OC,Ribeiro Eda S,Kurachi C,Quintana SM,Lombardi W,Bagnato VS

    更新日期：2012-03-01 00:00:00

  • Therapeutic evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in Bowenoid papulosis.

    abstract：BACKGROUND:Bowenoid papulosis is a polymorphic papular disease that occurs on the external genital area. We investigated the efficacy of 5-aminolevulinic acid-mediated photodynamic therapyin the treatment of Bowenoid papulosis. METHODS:We investigated 200 Bowenoid papulosis cases from the Department of Dermatology and...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.101635

    authors： Che Q,Li J,Wang J,Wang Q,Jiang L,Li Z,Liu H,Zhang M,Zeng K

    更新日期：2020-03-01 00:00:00

  • Low-cost light-induced therapy to treat rickettsial infection.

    abstract：:Antimicrobial photodynamic therapy uses a nontoxic photosensitizer with the assistance of harmless visible light to activate the photosensitizer. Consequently, the excited state of the photosensitizer interacts with molecular oxygen to produce reactive oxygen species, which have the antimicrobial effect. In this study...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.09.018

    authors： Špitalská E,Špitalský Z,Markovic Z,Štefanidesová K,Škultéty Ľ

    更新日期：2018-12-01 00:00:00

  • 5-aminolevulinic acid photodynamic therapy enhance the effect of acitretin on squamous cell carcinoma cells: An in vitro study.

    abstract：:Squamous cell carcinoma (SCC) remains the second most common nonmelanoma skin cancer (NMSC) worldwide. Both acitretin and 5-Aminolevulinic acid mediated photodynamic therapy (ALA-PDT) have validated effect on SCC. However, the effects of both treatmens remain limited, and there has been no report concerning the potent...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101887

    authors： Ye T,Jiang B,Chen B,Liu X,Yang L,Xiong W,Yu B

    更新日期：2020-09-01 00:00:00

  • Atypical polypoid adenomyoma treated by hysteroscopy with photodynamic diagnosis using 5-aminolevulinic acid: A case report.

    abstract：:Surgical resection for atypical polypoid adenomyoma (APA) is an option for fertility preservation. Due to the high recurrence rate of APA, studies have been conducted to improve total resection of tumors. Photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) improves tumor resection, but this has not been a...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.06.019

    authors： Matoba Y,Banno K,Kobayashi Y,Kisu I,Aoki D

    更新日期：2019-09-01 00:00:00

  • DAFE autofluorescence assessment of oral cavity, larynx and bronchus in head and neck cancer patients.

    abstract：:Head and neck (H&N) cancer patients have a high incidence of local field change as well as second primary lung tumours. We have applied the Wolf Diagnostic Autofluorescence Endoscopy (DAFE) system in a novel way, combining autofluorescence evaluation of both H&N region and bronchial. New H&N cases as well as "old" cas...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2006.07.004

    authors： Fielding D,Agnew J,Wright D,Hodge R

    更新日期：2006-12-01 00:00:00

  • The combination of antimicrobial photocatalysis and antimicrobial photodynamic therapy to eradicate the extensively drug-resistant colistin resistant Acinetobacter baumannii.

    abstract：BACKGROUND:The appearance of bacterial resistance to antibiotics a are major health problems. Antimicrobial photodynamic therapy (aPDT) has emerged as an adjunctive treatment for drug-resistant infections. Titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles have recently been proposed as effective carriers for p...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101816

    authors： Boluki E,Pourhajibagher M,Bahador A

    更新日期：2020-09-01 00:00:00

  • Surface treatment of RMGIC to composite resin using different photosensitizers and lasers: A bond assessment of closed Sandwich restoration.

    abstract：AIM:The aim of present study was to assess and compare different conditioning methods (laser, PDT and conventional) on shear bond strength (SBS) of resin modified glass ionomer cement (RMGIC) bonded to composite (sandwich technique). MATERIAL AND METHODS:Fifty specimens were prepared from RMGIC and were packed in a te...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101965

    authors： Ghubaryi AAA,Ingle N,Basser MA

    更新日期：2020-12-01 00:00:00

  • Monitoring the effectiveness of photodynamic therapy with periodic renewal of the photosensitizer on intracanal Enterococcus faecalis biofilms.

    abstract：BACKGROUND AND OBJECTIVE:Photodynamic therapy (PDT) can eliminate microorganisms in a root canal. However, the parameters for disinfection remain undefined. This study assessed the effectiveness of a PDT protocol against intracanal Enterococcus faecalis biofilms. MATERIALS AND METHODS:Root canals were contaminated wit...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.01.002

    authors： Soares JA,Santos Soares SMC,Santos César CA,de Carvalho MAR,Brito-Júnior M,de Sousa GR,Soares BM,de Macêdo Farias L

    更新日期：2016-03-01 00:00:00

  • Evaluation of ALA-PDT combined with antibiotics for the treatment of skin ulcers with sinus tract formation: A pilot study.

    abstract：BACKGROUND:Photodynamic therapy (PDT) is considered an important and innovative treatment for healing skin wounds. Skin ulcers with sinus tract formation are rare and difficult to treat in the field of dermatology. Herein, we utilized optical fibers as a light source to penetrate the sinus tract and applied PDT to trea...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101802

    authors： Tan Y,Bai Y,Li F,Chen J,Cheng Q,Wang J,Li J,Lei X

    更新日期：2020-09-01 00:00:00

  • Comparison of 5-aminolevulinic acid photodynamic therapy and red light for treatment of photoaging.

    abstract：OBJECTIVE:The aim of this pilot study was to compare the efficacy of ALA-PDT and red light alone in the treatment of photoaging. METHODS:A total of 14 adults with photoaging skin were recruited. ALA-PDT or red light alone was applied to the forearm extensor. Before and after treatment, the treated sites were examined ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2014.02.007

    authors： Ji J,Zhang LL,Ding HL,Wang HW,Huang Z,Wang XX,Wang PR,Wang XL

    更新日期：2014-06-01 00:00:00

  • PDT experience in Brazil: A regional profile.

    abstract：:The success of PDT and its establishment into the existent hall of therapeutic modalities depends on the collection of reported experiences from around the world. In that sense, it is important to report approaches taken by different countries and what their views are on the future of PDT. Following this idea, we pres...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/S1572-1000(05)00058-X

    authors： Bagnato VS,Kurachi C,Ferreira J,Marcassa LG,Sibata CH,Allison RR

    更新日期：2005-06-01 00:00:00

  • Photodynamic effect of curcumin on Vibrio parahaemolyticus.

    abstract：:Vibrio parahaemolyticus (V. parahaemolyticus) is currently a major cause of bacterial diarrhoea associated with seafood consumption. The objective of this study was to determine the inactivation effect of curcumin-mediated photodynamic action on V. parahaemolyticus. First of all, V. parahaemolyticus suspended in PBS b...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2016.05.004

    authors： Wu J,Mou H,Xue C,Leung AW,Xu C,Tang QJ

    更新日期：2016-09-01 00:00:00

  • Targeted photodynamic-induced singlet oxygen production by peptide-conjugated biodegradable nanoparticles for treatment of skin melanoma.

    abstract：BACKGROUND:Photodynamic therapy (PDT) has been determined to be a promising treatment modality in the most resistant tumors such as malignant melanoma. However, the key cytotoxic agent of PDT, -singlet oxygen (1O2) - represents a high risk of photodynamic-associated side effects e.g. skin photosensitization. Recently, ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.05.017

    authors： Sebak AA,Gomaa IEO,ElMeshad AN,AbdelKader MH

    更新日期：2018-09-01 00:00:00

  • 5-aminolevulinic acid mediated photodynamic therapy inhibits survival activity and promotes apoptosis of A375 and A431 cells.

    abstract：OBJECTIVES:The purpose of this study was to investigate the effects of 5-aminolaevulinic acid mediated photodynamic therapy (ALA-PDT) on the survival activity and apoptosis of human melanoma cell line A375 and non-melanoma skin carcinoma cell line A431 cells. The mechanism for cellular apoptosis was explored. METHODS:...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.01.004

    authors： Cai J,Zheng Q,Huang H,Li B

    更新日期：2018-03-01 00:00:00

  • Antibacterial effect of S-Porphin sodium photodynamic therapy on Staphylococcus aureus and multiple drug resistance Staphylococcus aureus.

    abstract：BACKGROUND:Antibacterial photodynamic therapy (aPDT) has been proposed as an alternative strategy to inactivate bacteria. This study was designed to investigate the antibacterial effect of a novel photosensitizer S-Porphin sodium (S-PS) on plankton and biofilm cultures of Staphylococcus aureus (S. aureus) and its multi...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.08.031

    authors： Jia M,Mai B,Liu S,Li Z,Liu Q,Wang P

    更新日期：2019-12-01 00:00:00

  • Pharmacokinetics and biodistribution of Photolon (Fotolon) in intact and tumor-bearing rats.

    abstract：BACKGROUND:This paper provides the results of the non-clinical evaluation of biodistribution of the PS Photolon in inner organs and tissues of intact and tumor-bearing rats with xenograft tumors of different morphologic types. METHODS:The accumulation studies were performed in rats by means of intravital laser fluorim...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2009.04.002

    authors： Shliakhtsin SV,Trukhachova TV,Isakau HA,Istomin YP

    更新日期：2009-06-01 00:00:00

  • Synergistic effect of methylene blue and biogenic gold nanoparticles against Enterococcus faecalis.

    abstract：:This study reports successful photodynamic inactivation of planktonic and biofilm cells of Enterococcus faecalis using Methylene Blue (MB) in combination with gold nanoparticles synthesized using the cell-free filtrate obtained from 3-day biomass of Trichoderma asperellum strain. Monodispersed colloidal gold nanoparti...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.05.042

    authors： Maliszewska I,Wróbel J,Wanarska E,Podhorodecki A,Matczyszyn K

    更新日期：2019-09-01 00:00:00

  • Dissecting cellulitis of the scalp successfully treated with ALA-PDT: Case report.

    abstract：:A case of recalcitrant dissecting cellulitis of the scalp (DCS) in a 23-year-old male patient was treated with 4 times of topical ALA-PDT at intervals of 10-15 days. The patient responded well without any unbearable adverse effects and presented satisfactory effects. Before applying this therapy, the patient and his d...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.10.001

    authors： Zhan Y,Chen X,Zhou Y,Zou P,Xiao R

    更新日期：2018-12-01 00:00:00

  • The optical imaging of idiopathic paracentral acute middle maculopathy in a Chinese young man and review of the literature.

    abstract：:We report a case of idiopathic paracentral acute middle maculopathy with typical optical imaging and clinical features. A 26-year-old Chinese policeman presented with a 20-day history of paracentral scotoma in the left eye after early wake-up and long-time working in front of computer the day before. He experienced su...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2017.07.004

    authors： Chen Y,Hu Y

    更新日期：2017-09-01 00:00:00

  • Real-world experience with 5-aminolevulinic acid for the photodynamic diagnosis of bladder cancer: Diagnostic accuracy and safety.

    abstract：BACKGROUND:5-Aminolevulinic acid (ALA)-mediated photodynamic diagnosis (PDD) has recently been approved in Japan for the management of non-muscle invasive bladder cancer. As such, the current study aimed to investigate the real-world diagnostic accuracy and safety of ALA-PDD-assisted transurethral resection of bladder ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101999

    authors： Yamamoto S,Fukuhara H,Karashima T,Inoue K

    更新日期：2020-12-01 00:00:00