当前位置： SCI文献检索 > Photodiagnosis and Photodynamic Therapy期刊下所有文献 > Evaluation of ALA-PDT combined with antibiotics for the treatment of skin ulcers with sinus tract formation: A pilot study.

Evaluation of ALA-PDT combined with antibiotics for the treatment of skin ulcers with sinus tract formation: A pilot study.

Abstract：

BACKGROUND:Photodynamic therapy (PDT) is considered an important and innovative treatment for healing skin wounds. Skin ulcers with sinus tract formation are rare and difficult to treat in the field of dermatology. Herein, we utilized optical fibers as a light source to penetrate the sinus tract and applied PDT to treat the sinus tract. OBJECTIVES:To evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and provide insight into the use of ALA-PDT in the treatment of skin ulcers with sinus tracts. METHODS:Seven patients with skin ulcers with sinus tract formation who were previously unsuccessfully treated with systemic antibiotics, debridement and dressing changes were examined. In the present study, these patients also received ALA-PDT treatment (the ulcers were irradiated with a red LED, and the sinus tracts were irradiated with semiconductor laser optical fibers), which was locally administered every 10 days with a total of 1-5 sessions. RESULTS:Six patients enrolled in the study were fully cured after receiving combination therapy with ALA-PDT and antibiotics for three months. The sinus tract of one patient was cured and the ulcer area of this patient was reduced. All patients experienced varying degrees of redness and pain during treatment but no severe discomfort, and all patients were satisfied with the outcome of the treatment. CONCLUSION:Local ALA-PDT combined with antibiotics could be a safe and effective treatment approach for skin ulcers with sinus tract formation.

journal_name

Photodiagnosis Photodyn Ther

journal_title

Photodiagnosis and photodynamic therapy

authors

Tan Y,Bai Y,Li F,Chen J,Cheng Q,Wang J,Li J,Lei X

doi

10.1016/j.pdpdt.2020.101802

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

101802

eissn

1572-1000

issn

1873-1597

pii

S1572-1000(20)30156-3

journal_volume

31

pub_type

杂志文章

相关文献

Photodiagnosis and Photodynamic Therapy文献大全
  • Photodynamic therapy in treatment of port wine stain birthmarks--recent progress.

    abstract：:Port wine stain (PWS) birthmarks are congenital vascular malformations characterized by ectatic capillaries in the papillary layer of the dermis. They usually appear at birth and tend to become darker and thicker with age. Cosmetic and pathological changes can cause great depression in all ages. Laser-mediated selecti...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,评审

    doi：10.1016/j.pdpdt.2009.08.001

    authors： Yuan KH,Li Q,Yu WL,Huang Z

    更新日期：2009-09-01 00:00:00

  • Therapeutic evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in Bowenoid papulosis.

    abstract：BACKGROUND:Bowenoid papulosis is a polymorphic papular disease that occurs on the external genital area. We investigated the efficacy of 5-aminolevulinic acid-mediated photodynamic therapyin the treatment of Bowenoid papulosis. METHODS:We investigated 200 Bowenoid papulosis cases from the Department of Dermatology and...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.101635

    authors： Che Q,Li J,Wang J,Wang Q,Jiang L,Li Z,Liu H,Zhang M,Zeng K

    更新日期：2020-03-01 00:00:00

  • Photodynamic therapy in China: Over 25 years of unique clinical experience Part One-History and domestic photosensitizers.

    abstract：:Photodynamic therapy (PDT) was started in the People's Republic of China in the early 1980s after domestically produced hematoporphyrin derivative (HpD) became available. Since then, numerous photosensitizers have been synthesized and evaluated. Several promising ones have undergone clinical investigations and a few h...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/S1572-1000(06)00009-3

    authors： Huang Z

    更新日期：2006-03-01 00:00:00

  • Comparison between the outcomes of fluorescein angiography-guided and indocyanine green angiography-guided half-time photodynamic therapy for central serous chorioretinopathy.

    abstract：BACKGROUND AND OBJECTIVES:This study aimed to compare the efficacy of fluorescein angiography (FA)-guided and indocyanine green angiography (ICGA)-guided half-time photodynamic therapy (PDT) for central serous chorioretinopathy (CSC). SUBJECTS AND METHODS:Medical records of 61 eyes of 61 CSC patients who underwent hal...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101955

    authors： Hayashida M,Miki A,Honda S,Nakamura M

    更新日期：2020-09-01 00:00:00

  • An in vitro study on the photosensitivity of 5-aminolevulinic acid conjugated gold nanoparticles.

    abstract：BACKGROUND:In this study, the photosensitivity of 5-aminolevulinic acid (5-ALA) conjugated gold nanoparticles (conjugate) has been investigated on the MeL-Rm cell line. METHODS:After culture and proliferation of the Mel-Rm cell line, cell toxicity and the suitable cell incubation time of the conjugate were determined....

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2013.03.010

    authors： Mohammadi Z,Sazgarnia A,Rajabi O,Soudmand S,Esmaily H,Sadeghi HR

    更新日期：2013-12-01 00:00:00

  • The effect of indocyanine green-based photodynamic therapy on healthy fibroblast and keratinocyte cells.

    abstract：BACKGROUND:Photodynamic therapy is a promising invention to treat infections and cancer where conventional treatments are insufficient and have many side effects. Photodynamic therapy is mainly emphasized as having minimal side effects on healthy cells during local applications, even so photosensitizer can accumulate i...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101891

    authors： Topaloğlu N,Kadıköylü G,Onak G,Karaman O

    更新日期：2020-09-01 00:00:00

  • Conventional versus daylight photodynamic therapy for actinic keratosis: A randomized and prospective study in China.

    abstract：BACKGROUND:Conventional photodynamic therapy (C-PDT) is an effective treatment for actinic keratoses (AKs) in Asia, with some unmet needs. Severe PDT-associated pain results in low treatment willingness. Daylight photodynamic therapy (DL-PDT) is a more simple and tolerable treatment that has the same efficacy as C-PDT ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pdpdt.2018.10.010

    authors： Zhu L,Wang P,Zhang G,Zhang L,Liu X,Hu C,Yang X,Sroka R,Zhou Z,Wang X

    更新日期：2018-12-01 00:00:00

  • Successful treatment for multiple Bowen's disease using photodynamic therapy: A case report.

    abstract：:Bowen's disease, also named squamous cell carcinoma in situ, is usually treated by surgical excision. However, surgery is not suitable to patients with large area of lesions, multiple lesions or in cosmetically important areas where a scar will be visible. Photodynamic therapy (PDT) has advantages of efficacy, safety,...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type：

    doi：10.1016/j.pdpdt.2020.101783

    authors： Wu MF,Lv T,Wang HW

    更新日期：2020-06-01 00:00:00

  • Effects of dental bleaching protocols with violet radiation on the color and chemical composition of stained bovine enamel.

    abstract：OBJECTIVES:To evaluate the bleaching efficacy of a violet radiation (VR) combined or not with bleaching gels on the color and mineral content of stained teeth. MATERIAL AND METHODS:Enamel/dentin blocks were obtained and stained (n = 50) with coffee, red wine, tobacco smoke, or were left non-stained. The stained or not...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2021.102194

    authors： Kobayashi RS,Picolo MZD,Kury M,de Almeida Resende B,Florez FLE,Cavalli V

    更新日期：2021-01-26 00:00:00

  • Effects of low-dose ALA-PDT on fibroblast photoaging induced by UVA irradiation and the underlying mechanisms.

    abstract：OBJECTIVES:To investigate the effects of low-dose aminolevulinic acid photodynamic therapy (ALA-PDT) on photoaging in human dermal fibroblasts (HDFs) and to explore the mechanism of Nuclear factor erythroid 2-related factor 2(Nrf2)-mediated photorejuvenation in vitro. METHODS:A photoaging model was established through...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.05.006

    authors： Chen J,Luo J,Tan Y,Wang M,Liu Z,Yang T,Lei X

    更新日期：2019-09-01 00:00:00

  • Does the temperature gradient correlate with the photodynamic diagnosis parameter numerical colour value (NCV)?

    abstract：BACKGROUND:Photodynamic diagnosis (PDD) as well as thermovision belong to the category of non-invasive optical diagnosis techniques. Among many different skin cancer diseases, basal cell carcinoma (BCC) is the most frequently occurring one (almost 95% of all skin tumours). In contrast, seborrhoeic keratosis represents ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.07.001

    authors： Cholewka A,Stanek A,Kwiatek S,Sieroń A,Drzazga Z

    更新日期：2013-02-01 00:00:00

  • In vitro photodynamic inactivation of Candida species and mouse fibroblasts with phenothiazinium photosensitisers and red light.

    abstract：:In the present study, the in vitro susceptibilities of five Candida spp. to photodynamic antimicrobial chemotherapy (PACT) with four phenothiazinium derivatives, methylene blue (MB), new methylene blue N (NMBN), toluidine blue O (TBO) and the novel pentacyclic phenothiazinium photosensitiser S137, in combination with ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.11.004

    authors： Rodrigues GB,Dias-Baruffi M,Holman N,Wainwright M,Braga GU

    更新日期：2013-05-01 00:00:00

  • Treatment of verrucous carcinoma in penis with topical aminolevulinic acid photodynamic therapy: An effective and safe treatment method.

    abstract：BACKGROUND:Verrucous carcinoma of the penis is a rare disease characterized by verrucous lesions. The traditional treatment methods for verrucous carcinoma result in loss of sexual function are not satisfactory. The purpose of this study was to evaluate the safety and effect of topical aminolevulinic acid photodynamic ...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.08.015

    authors： He X,Zhang J,Tan L,Wang W,Song Y,Wang H,Zhang X,Kou H,Lu Y

    更新日期：2018-12-01 00:00:00

  • Long-term Improvement on Photoaging After ALA Photodynamic Therapy for Actinic Keratosis: A Retrospective Study.

    abstract：BACKGROUND:5-aminolevulinic acid photodynamic therapy (ALA-PDT) is not only the first-line treatment for actinic keratosis (AK), but also demonstrated to improve photoaging during AK field treatment. However, its long-term improvement effect on photoaging remains elusive. OBJECTIVE:To evaluate the long-term improvemen...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2021.102181

    authors： Zhang L,Zhao Z,Wang P,Zhang G,Wang B,Shi L,Liu X,Zhou Z,Wang X

    更新日期：2021-01-08 00:00:00

  • Low-cost light-induced therapy to treat rickettsial infection.

    abstract：:Antimicrobial photodynamic therapy uses a nontoxic photosensitizer with the assistance of harmless visible light to activate the photosensitizer. Consequently, the excited state of the photosensitizer interacts with molecular oxygen to produce reactive oxygen species, which have the antimicrobial effect. In this study...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.09.018

    authors： Špitalská E,Špitalský Z,Markovic Z,Štefanidesová K,Škultéty Ľ

    更新日期：2018-12-01 00:00:00

  • Antimicrobial photodynamic therapy for infectious stomatitis in snakes: Clinical views and microbiological findings.

    abstract：BACKGROUND:Antimicrobial photodynamic therapy (APDT) has been broadly investigated as an alternative to treat localized infections, without leading to the selection of resistant microorganisms. Infectious stomatitis is a multifactorial disease frequently reported in captive snakes characterized by infection of the oral...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2017.10.004

    authors： Grego KF,Carvalho MPN,Cunha MPV,Knöbl T,Pogliani FC,Catão-Dias JL,Sant'Anna SS,Ribeiro MS,Sellera FP

    更新日期：2017-12-01 00:00:00

  • Interference with the Jaffé method for creatinine following 5-aminolevulinic acid administration.

    abstract：BACKGROUND:The photosensitizer pro-drug 5-aminolevulinic acid (5-ALA) has been administered systemically for photodynamic therapy. Although several toxicities have been reported, nephrotoxicity has never been observed. MATERIALS AND METHODS:Patients with head and neck mucosal dysplasia have been treated on a phase 1 s...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2010.07.008

    authors： Quon H,Grossman CE,King RL,Putt M,Donaldson K,Kricka L,Finlay J,Zhu T,Dimofte A,Malloy K,Cengel KA,Busch TM

    更新日期：2010-12-01 00:00:00

  • Treatment of infected wounds with methylene blue photodynamic therapy: An effective and safe treatment method.

    abstract：BACKGROUND:Bacterial resistance is a problem during the process of healing of infected wounds. As a therapy, photodynamic therapy (PDT) has broad-spectral antibacterial activity and non-selective action, which makes it possible to deal with antibiotic resistance.. Methylene blue is a commonly used medicine, but it is r...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.102051

    authors： Shen X,Dong L,He X,Zhao C,Zhang W,Li X,Lu Y

    更新日期：2020-12-01 00:00:00

  • Hyperthermia enhances the antitumor effect of photodynamic therapy with ALA hexyl ester in a squamous cell carcinoma tumor model.

    abstract：BACKGROUND:Photodynamic therapy (PDT) using 5-aminolevulinic acid is considered to be ineffective in the treatment of tumors with progression to the deep layer. Therefore, for such tumors, a method is required which can enhance the effectiveness of this therapy. We examined the anti tumor effect of the combination of P...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2012.04.003

    authors： Yanase S,Nomura J,Matsumura Y,Kato H,Tagawa T

    更新日期：2012-12-01 00:00:00

  • Immunohistochemical investigation of predictors of response or aggressiveness of bowen disease after photodynamic therapy.

    abstract：BACKGROUND:Photodynamic therapy (PDT) is a good option for the treatment of Bowen's disease (BD). However, BD occasionally can progress into a squamous cell carcinoma (SCC) after PDT. OBJECTIVE:Find predictors of aggressiveness of BD after PDT METHODS: Two biopsies of patients with BD treated with PDT with progression...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.02.004

    authors： Fernández-Guarino M,Morales MLG,Bernal I,Adrada AIS,Ugia SP,Garde JB

    更新日期：2018-06-01 00:00:00

  • Antibacterial effect of S-Porphin sodium photodynamic therapy on Staphylococcus aureus and multiple drug resistance Staphylococcus aureus.

    abstract：BACKGROUND:Antibacterial photodynamic therapy (aPDT) has been proposed as an alternative strategy to inactivate bacteria. This study was designed to investigate the antibacterial effect of a novel photosensitizer S-Porphin sodium (S-PS) on plankton and biofilm cultures of Staphylococcus aureus (S. aureus) and its multi...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.08.031

    authors： Jia M,Mai B,Liu S,Li Z,Liu Q,Wang P

    更新日期：2019-12-01 00:00:00

  • Multimodal cancer cell therapy using Au@Fe2O3 core-shell nanoparticles in combination with photo-thermo-radiotherapy.

    abstract：:In this study, gold coated iron oxide nanoparticle (Au@Fe2O3 NP) was synthesized in a core-shell structure. Photothermal and radiosensitization effects of Au@Fe2O3 NPs were investigated on KB human mouth epidermal carcinoma cell line. Cell death and apoptosis were measured to study the effects of nanoparticles in comb...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2018.08.003

    authors： Hosseini V,Mirrahimi M,Shakeri-Zadeh A,Koosha F,Ghalandari B,Maleki S,Komeili A,Kamrava SK

    更新日期：2018-12-01 00:00:00

  • Surgical interventions combined with photodynamic therapy in the treatment of Perifolliculitis Capitis Abscendens et Suffodiens: Report of 5 cases.

    abstract：:Perifolliculitis capitis abscedens et suffodiens (PCAS), also known as dissecting cellulitis of the scalp (DCS), is a rare, chronic, suppurative inflammatory disease of the scalp which may evolve into cicatricial alopecia. Its refractory nature has a detrimental impact on patients' quality of life. Here, we report fiv...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101660

    authors： Liu H,Ding A,Aloke G,Mvogo Ndzana LB,Wan M,Lin Y,Zhang J

    更新日期：2020-06-01 00:00:00

  • An investigation of the fluorescence induced by topical application of 5-aminolaevulinic acid and methyl aminolaevulinate at different body sites on normal human skin.

    abstract：BACKGROUND:Although discovered over a century ago it is only in the last 25 years that photodynamic therapy (PDT) has been the focus of intense research. This versatile treatment modality has been shown to be effective in treating a wide variety of malignancies, and with the increasing incidence of non-melanoma skin ca...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2010.12.004

    authors： Lesar A,Ferguson J,Moseley H

    更新日期：2011-06-01 00:00:00

  • Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy.

    abstract：BACKGROUND:We report on a Phase 1 trial of photodynamic therapy (PDT) for superficial head and neck (H&N) lesions. Due to known oxygen dependencies of PDT, translational measurements of lesion hemoglobin oxygen saturation (StO2) and blood volume (tHb) were studied for associations with patient outcomes. METHODS:PDT wi...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2017.10.015

    authors： Ahn PH,Finlay JC,Gallagher-Colombo SM,Quon H,O'Malley BW Jr,Weinstein GS,Chalian A,Malloy K,Sollecito T,Greenberg M,Simone CB 2nd,McNulty S,Lin A,Zhu TC,Livolsi V,Feldman M,Mick R,Cengel KA,Busch TM

    更新日期：2018-03-01 00:00:00

  • Synergistic effect of methylene blue and biogenic gold nanoparticles against Enterococcus faecalis.

    abstract：:This study reports successful photodynamic inactivation of planktonic and biofilm cells of Enterococcus faecalis using Methylene Blue (MB) in combination with gold nanoparticles synthesized using the cell-free filtrate obtained from 3-day biomass of Trichoderma asperellum strain. Monodispersed colloidal gold nanoparti...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2019.05.042

    authors： Maliszewska I,Wróbel J,Wanarska E,Podhorodecki A,Matczyszyn K

    更新日期：2019-09-01 00:00:00

  • Pharmacokinetics and biodistribution of Photolon (Fotolon) in intact and tumor-bearing rats.

    abstract：BACKGROUND:This paper provides the results of the non-clinical evaluation of biodistribution of the PS Photolon in inner organs and tissues of intact and tumor-bearing rats with xenograft tumors of different morphologic types. METHODS:The accumulation studies were performed in rats by means of intravital laser fluorim...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2009.04.002

    authors： Shliakhtsin SV,Trukhachova TV,Isakau HA,Istomin YP

    更新日期：2009-06-01 00:00:00

  • Clinical study on clinical operation and post-treatment reactions of HMME-PDT in treatment of PWS.

    abstract：OBJECTIVE:To analyze the clinical efficacy of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating port-wine stains (PWS), and its clinical operation skills and operation essentials. METHOD:A total of 16 cases of PWS with negative HMME skin test results were included in this study. Their treate...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章,评审

    doi：10.1016/j.pdpdt.2017.09.013

    authors： Zhang Y,Zou X,Chen H,Yang Y,Lin H,Guo X

    更新日期：2017-12-01 00:00:00

  • Cost effective and efficient screening of tuberculosis disease with Raman spectroscopy and machine learning algorithms.

    abstract：:The current study presents Raman Spectroscopy (RS) accompanied by machine learning algorithms based on Principle Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA) for analysis of tuberculosis (TB). TB positive (diseased), TB negative (cured) and control (healthy) serum samples are considered for inter a...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101963

    authors： Ullah R,Khan S,Chaudhary II,Shahzad S,Ali H,Bilal M

    更新日期：2020-12-01 00:00:00

  • Photobiomodulation and antimicrobial photodynamic therapy for oral cytomegalovirus reactivation following acute graft-versus-host disease.

    abstract：:The relationship between cytomegalovirus (CMV), a severe complication in immunocompromised patients, and graft-versus-host disease (GVHD) has already been reported but remains without complete elucidation, especially concerning oral lesions. Considering that antimicrobial photodynamic therapy (aPDT) has an antimicrobi...

    journal_title：Photodiagnosis and photodynamic therapy

    pub_type： 杂志文章

    doi：10.1016/j.pdpdt.2020.101849

    authors： Rezende SB,Campos L,Palma LF,Tateno RY,Simões A,Macedo MC,Silva RLD

    更新日期：2020-12-01 00:00:00