Abstract：
:Photodynamic effect was a chance discovery early in the 1900s, demonstrating the lethal effects of light activated chemicals on living cells. Although the application of the principles of photodynamic effect to patients' treatment and what became photodynamic therapy (PDT) was practiced in 1960s and 1970s, clinical trials were only started in the 1980s, following successful synthesis of clinically usable photosensitisers (drugs) and the manufacturing of light sources. We briefly review and highlight some of the landmarks of the development of clinical PDT in Europe.
journal_name
Photodiagnosis Photodyn Therjournal_title
Photodiagnosis and photodynamic therapyauthors
Mitton D,Ackroyd Rdoi
10.1016/j.pdpdt.2008.04.004subject
Has Abstractpub_date
2008-06-01 00:00:00pages
103-11issue
2eissn
1572-1000issn
1873-1597pii
S1572-1000(08)00040-9journal_volume
5pub_type
杂志文章,评审abstract：:A phenaxazone compound [5H-Benzo[a]phenoxazin-5-one (BP)] along with an aminoquinone[2-[(o-hydroxyphenyl)amino]-1,4-naphthaquinone (HAN)] derivatives were synthesized from lawsone using ultrasound irradiation technique. The structure of the compounds were characterized by elemental analysis and various spectral studie...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2017.01.180
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Recently, photodynamic diagnosis using 5-aminolevulinic acid (5-ALA) has gained attention for the diagnosis of neoplastic diseases. In the present study, anin vitro method of photodynamic cytodiagnosis (PDCD) performed using the reagent 5-ALA in the cytodiagnosis of solid pancreatic tumors was developed. Her...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2019.101581
更新日期：2019-10-16 00:00:00
abstract：BACKGROUND:Superluminescent diodes (sLED) appear to be an innovative and promising light source in photodynamic therapy (PDT), especially in actinic keratosis (AK) lesions treatment. AIM:Assessment of tolerability and efficacy of sLED in topical 5-aminolevulinic acid (ALA) PDT of AK lesions. METHODS:27 patients recei...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2018.04.010
更新日期：2018-06-01 00:00:00
abstract：:Photodynamic therapy (PDT) was started in the People's Republic of China in the early 1980s after domestically produced hematoporphyrin derivative (HpD) became available. Since then, numerous photosensitizers have been synthesized and evaluated. Several promising ones have undergone clinical investigations and a few h...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/S1572-1000(06)00009-3
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Light fractionation with a 2-h dark interval increases the efficacy of topical aminolevulinic acid (ALA) photodynamic therapy (PDT). Hexyl-aminolevulinate (HAL) is the hexyl ester of ALA. Both HAL and ALA lead to protoporphyrin IX (PpIX) accumulation in endothelial cells and to vascular effects, which are im...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2013.09.002
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:This study aimed to compare the efficacy of fluorescein angiography (FA)-guided and indocyanine green angiography (ICGA)-guided half-time photodynamic therapy (PDT) for central serous chorioretinopathy (CSC). SUBJECTS AND METHODS:Medical records of 61 eyes of 61 CSC patients who underwent hal...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2020.101955
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:This paper provides the results of the non-clinical evaluation of biodistribution of the PS Photolon in inner organs and tissues of intact and tumor-bearing rats with xenograft tumors of different morphologic types. METHODS:The accumulation studies were performed in rats by means of intravital laser fluorim...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2009.04.002
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVES:To evaluate the bleaching efficacy of a violet radiation (VR) combined or not with bleaching gels on the color and mineral content of stained teeth. MATERIAL AND METHODS:Enamel/dentin blocks were obtained and stained (n = 50) with coffee, red wine, tobacco smoke, or were left non-stained. The stained or not...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2021.102194
更新日期：2021-01-26 00:00:00
abstract：BACKGROUND:The objective of this study was to improve the feasibility of applying topic 5-aminolevulinic acid (ALA) in photodiagnosis (PD) and treatment of condyloma caused by human papillomavirus (HPV) using two homemade handheld devices and to discuss the photodynamic therapy (PDT) as a suitable alternative for each ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 临床试验,杂志文章
doi：10.1016/j.pdpdt.2011.09.001
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Oral lichen planus (OLP) is a chronic inflammatory disease. There is no standard treatment modality for OLP. Recently, photodynamic therapy (PDT) has been advocated as a new treatment modality for OLP. AIM:The aim of the present study is to compare the effect of PDT using methylene blue (MB) as a photosensi...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2020.101677
更新日期：2020-06-01 00:00:00
abstract：:Some basal cell carcinomas (BCCs) are indistinguishable from nevi based on clinical manifestations. Therefore, it is often difficult for the excision margins of the initial surgical treatment to achieve radical removal of the malignancy. This study was a comparative analysis of the clinical results of aminolevulinic a...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 临床试验,杂志文章
doi：10.1016/j.pdpdt.2016.11.003
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To compare a single treatment of PDL-PDT with PDT for BCCs in terms of efficacy, aesthetic outcome, and pain in patients with multiple BCCs. STUDY DESIGN/MATERIALS AND METHODS:A prospective, controlled, intra-individual, investigator-blinded study was conducted on 15 patients with 62 BCCs. The...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2016.08.003
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to determine the usefulness of a quantitative light-induced fluorescence (QLF) technology in detecting dental restorations by comparing the detection ability of dental hygiene students between using conventional visual inspection alone and visual inspection combined with QLF tec...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pdpdt.2016.12.010
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Various techniques have been suggested to quantitatively assess tooth wear; most have limited clinical application. The first aim of this in vitro study was to estimate the residual enamel thickness of teeth with various degrees of occlusal wear using quantitative light-induced fluorescence (QLF). The second...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2019.01.016
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Bowenoid papulosis is a polymorphic papular disease that occurs on the external genital area. We investigated the efficacy of 5-aminolevulinic acid-mediated photodynamic therapyin the treatment of Bowenoid papulosis. METHODS:We investigated 200 Bowenoid papulosis cases from the Department of Dermatology and...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2019.101635
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:In this study, the photosensitivity of 5-aminolevulinic acid (5-ALA) conjugated gold nanoparticles (conjugate) has been investigated on the MeL-Rm cell line. METHODS:After culture and proliferation of the Mel-Rm cell line, cell toxicity and the suitable cell incubation time of the conjugate were determined....
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2013.03.010
更新日期：2013-12-01 00:00:00
abstract：:Today, the widespread use of laser instruments in various fields has resulted in many accidental retinal injuries. Here we describe a rare clinical case of full-thickness macular hole (MH) and focal choroidal excavation (FCE) caused by a 1064-nm Q-switched Nd:YAG laser. After pars plana vitrectomy and the following 14...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2017.07.001
更新日期：2017-09-01 00:00:00
abstract：:Molecular modification of protoporphyrin IX (PpIX) was conducted to improve its water solubility and therapeutic performance for photodynamic therapy. The carboxylic acid and the two nitrogen atoms in the core of PpIX molecule were protonated following by conjugation with 3-aminopropyl triethoxysilane (APTES). Then, f...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2015.01.003
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to investigate the effects of 5-aminolaevulinic acid mediated photodynamic therapy (ALA-PDT) on the survival activity and apoptosis of human melanoma cell line A375 and non-melanoma skin carcinoma cell line A431 cells. The mechanism for cellular apoptosis was explored. METHODS:...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2018.01.004
更新日期：2018-03-01 00:00:00
abstract：AIM:This study aimed to compare the antibacterial effect of antimicrobial photodynamic therapy (aPDT) by use of light emitting diode (LED) and diode laser light sources with toluidine blue (TBO) photosensitizer on Enterococcus faecalis (E. faecalis) biofilm in root canals of extracted single-canal human teeth. METHODS...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2020.102036
更新日期：2020-12-01 00:00:00
abstract：INTRODUCTION:Clinical studies have shown the usefulness of antimicrobial photodynamic therapy (aPDT) as an adjunctive in periodontal therapy. These studies did not utilize indocyanine green (ICG) as a recently introduced photosensitizer. The aim of this study was to perform a full-mouth double-blind randomized controll...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pdpdt.2016.02.007
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:One of the most frequent type of malignant skin lesion (almost 95 percent of all skin tumours) is basal cell carcinoma (BCC). It is often treated by radiotherapy using ionizing radiation as well by photodynamic therapy (PDT) which is a selective method directed only on cancer cells and well tolerated by pati...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2020.101845
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Among the pathogens, Staphylococcus aureus is the main causative agent of bacterial diseases in the world. In this context, antimicrobial photodynamic therapy (aPDT) appears as a promising tool by means of microbial inactivation with the use of light. aPDT is applied in treatments involving photosensitizers ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2019.01.005
更新日期：2019-03-01 00:00:00
abstract：:Palmatine hydrochloride (PaH) is a natural active compound from a traditional Chinese medicine (TCM). The present study aims to evaluate the effect of PaH as a new photosensitizer on colon adenocarcinoma HT-29 cells upon light irradiation. Firstly, the absorption and fluorescence spectra of PaH were measured using a U...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2016.05.005
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Photodynamic therapy (PDT) has been determined to be a promising treatment modality in the most resistant tumors such as malignant melanoma. However, the key cytotoxic agent of PDT, -singlet oxygen (1O2) - represents a high risk of photodynamic-associated side effects e.g. skin photosensitization. Recently, ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2018.05.017
更新日期：2018-09-01 00:00:00
abstract：:Bowen's disease, also named squamous cell carcinoma in situ, is usually treated by surgical excision. However, surgery is not suitable to patients with large area of lesions, multiple lesions or in cosmetically important areas where a scar will be visible. Photodynamic therapy (PDT) has advantages of efficacy, safety,...
journal_title：Photodiagnosis and photodynamic therapy
pub_type：
doi：10.1016/j.pdpdt.2020.101783
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Nanosecond pulsed electric field (nsPEF) treatment is a new anti-cancer strategy with ultrashort pulse duration and high intensity of electric fields. The application of nsPEFs affects all intra- and extracellular membranes and independently initiates the process of apoptosis within cancer cells, leading the...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2015.11.002
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:The aim of this study is to evaluate the antimicrobial activity of hypochlorite solutions and reciprocating instrumentation associated with photodynamic therapy (PDT). METHODS:One hundred and thirty two root canals were enlarged up to #35 K-file and inoculated with E.faecalis for 14 days. The 132 samples ...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2018.07.015
更新日期：2018-09-01 00:00:00
abstract：:Port wine stain (PWS) birthmarks are congenital vascular malformations characterized by ectatic capillaries in the papillary layer of the dermis. They usually appear at birth and tend to become darker and thicker with age. Cosmetic and pathological changes can cause great depression in all ages. Laser-mediated selecti...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章,评审
doi：10.1016/j.pdpdt.2009.08.001
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Photodynamic therapy (PDT) can eliminate microorganisms in a root canal. However, the parameters for disinfection remain undefined. This study assessed the effectiveness of a PDT protocol against intracanal Enterococcus faecalis biofilms. MATERIALS AND METHODS:Root canals were contaminated wit...
journal_title：Photodiagnosis and photodynamic therapy
pub_type： 杂志文章
doi：10.1016/j.pdpdt.2016.01.002
更新日期：2016-03-01 00:00:00
