Abstract:
:Although cytotoxic chemotherapy is the main therapeutic option to treat gastric cancer in the metastatic setting, molecular targeted agents have recently been introduced in an effort to improve survival outcomes which in average do not exceed 1 year. Trastuzumab and ramucirumab, antibodies directed against HER2 and VEGFR2, respectively, may provide clinical benefit for some patients. Results of clinical studies show that Asian patients have increased survival compared to Caucasian patients. Differences between populations, and in particular the presence of polymorphisms capable of influencing the availability of fluorouracil, have been suggested as possible explanations. Other factors including histology, surgical procedures, administration of neoadjuvant chemotherapy in Western countries and screening programs in Asia have also been suggested. However, none of these elements can fully explain this phenomenon. The aim of this article is to present the main protocols used in clinical practice, the perspectives of metastatic gastric cancer treatment and the particularities observed in Asian and Caucasian patients.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Bui QL,Grazziotin-Soares D,Hasiniatsy RE,Trinh HS,Richard S,Lotz JP,Gligorov J,Khalil Adoi
10.1016/j.bulcan.2018.07.012subject
Has Abstractpub_date
2018-10-01 00:00:00pages
932-943issue
10eissn
0007-4551issn
1769-6917pii
S0007-4551(18)30233-9journal_volume
105pub_type
杂志文章,评审abstract::Cancer patients frequently undergo imaging examinations to diagnosis but also to evaluate their responses to treatment. These patients are also at high risk of kidney impairment before considering the possible nephrotoxicity of their chemotherapy. In this context, it is overriding to know contrast agents induced risks...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2011.1477
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journal_title:Bulletin du cancer
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journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:To assess the feasibility and efficacy of cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) without adjuvant chemotherapy for relapsed or persistent advanced ovarian cancer. METHODS:This observational study included stage IIIC ovarian cancer patients due to undergo CRS...
journal_title:Bulletin du cancer
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abstract::The association between cancer and dependence was estimated using a cross-sectional study among persons 75 years of age or-older in Tarn county (area with a cancer registry recognized by the National Committee of Registries). A representative random sample stratified on age, sex, and size of district, was drawn using ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
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abstract::Improved techniques for inducing heat: ultrasound, microwaves, diathermy with different application modalities, capable of producing localized superficial or deep, regional or total body hyperthermia have been responsible for the multiplication of clinical trials. These studies have confirmed the tumoricidal effect of...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:1981-01-01 00:00:00
abstract::Estrogen receptors (ER) were investigated using immunohistochemical techniques in 54 cases and biochemical techniques in 38 cases on a series of biopsy specimens of normal, hyperplasic and malignant mammary tissue (intraductal carcinoma). Immunohistochemical data were submitted to quantitative and semi-quantitative an...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2008.0638
更新日期:2008-05-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2011.1390
更新日期:2011-07-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Multidrug resistant (MDR) phenotype is characterized by a defect in drug accumulation caused by overexpression of a transmembrane glycoprotein, the P-glycoprotein (P-gp). MDR phenotype can be characterized either with monoclonal antibodies raised against P-gp or with functional tests, most often based on the incorpora...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::In 2003, there was 147,000 deaths attributed to cancer in France, 88,000 in men and 59,000 in women. Cancer mortality rates have been decreasing since 1987 in the male population and since the late 60's in the female population, the decrease is larger for the male population. This decrease is observed for most sites o...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2016.03.003
更新日期:2016-07-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2008.0733
更新日期:2008-10-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2014.2026
更新日期:2014-12-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::For more than a decade, Transforming Growth Factor Beta (TGF beta) has been intensively studied. Such studies have led to the identification of many related polypeptides which constitute the TGF beta family. These factors modulate many animal cell processes such as cell cycle progression, differentiation, adhesion, mi...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract::Management of rectal cancers with synchronous metastasis is difficult. We evaluated in 23 patients a combination of pelvic radiotherapy at the dose of 45 Gy in 5 weeks and 25 fractions with chemotherapy by 5-fluorouracil (350 mg/m2/day) and folinic acid (20 mg/m2/day) for 5 days at the time of the first and the fifth ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2016.02.006
更新日期:2016-05-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2011.1366
更新日期:2011-06-09 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1976-07-01 00:00:00
abstract::By the genetic localization of the first melanoma susceptibility gene on chromosome 1p we thought that the puzzle on familial melanoma families would soon be solved. Now, almost fifteen years later we have learned that inherited melanoma is not a simple genetic disorder and that multiple genes, modifying genes and env...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::Northern France is known to have the highest mortality rate for cancers of the upper aerodigestive tract (UADT); a UADT cancer registry was therefore set up in this region in January 1984. Three years of meticulous registration provided some significant information. The incidence of UADT cancer was alarming: 4538 UADT...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::Lung and head and neck cancers result from a multistep process involving activation of oncogenes and inactivation of tumor-suppressor genes. These two processes share common features and molecular players, while their corresponding clinical entities are both triggered by the tobacco carcinogens. In many cases, the mol...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2009.0786
更新日期:2009-01-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2020.08.011
更新日期:2020-11-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00