Abstract：
:For more than a decade, Transforming Growth Factor Beta (TGF beta) has been intensively studied. Such studies have led to the identification of many related polypeptides which constitute the TGF beta family. These factors modulate many animal cell processes such as cell cycle progression, differentiation, adhesion, migration, extracellular matrix production, tissue development and repair processes. Recent studies have shown that TGF beta has also a cardioprotective effect and is implicated in inflammatory process. The mechanism by which cytokines of the TGF beta family initiate their many biological effects are not yet fully understood. However, the recent molecular cloning of various TGF beta receptor genes has provided many clues to address these questions. These findings have led to a proposition of an original and specific model for the mechanism of action of TGF beta.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Benzakour Osubject
Has Abstractpub_date
1994-12-01 00:00:00pages
1014-22issue
12eissn
0007-4551issn
1769-6917journal_volume
81pub_type
杂志文章,评审abstract：:CD44 gene products are potential markers of aggressiveness in different tumor models, a result which prompted us to study clinical neuroblastoma (NB) specimens. CD44 expression was determined by immunostaining of 52 NB with a monoclonal antibody (J173) directed against an epitope common to all CD44 isoforms. All tumor...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Angiogenin is one of the most potent inducers of neovascularization in experimental models in vivo. Angiogenin is normally present in plasma but overexpressed in cancer patients. The possible involvement of angiogenin in the development of cancer is suggested by its overexpression in patients with a variety of tumours...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2001-08-01 00:00:00
abstract：:Neuroblastoma is the most common pediatric extracranial solid cancer. Patients with metastatic disease at initial diagnosis who are greater than 18 months of age and patients with MycN amplified locoregional tumors are treated with intensive multimodal therapy. While this intensive approach has been shown to improve ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2011.1353
更新日期：2011-05-01 00:00:00
abstract：:Carcinomas are rare tumors of the adolescent-young adult (AYA) with a different spectrum from those of adults. The most common sites outside of the thyroid is the nasopharynx, salivary gland, colon-rectum and ovaries. If nasopharyngeal carcinoma or salivary gland tumors are good prognosis, others are more reserved pro...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2016.11.013
更新日期：2017-03-01 00:00:00
abstract：:This review reports 3 of recently published molecular classifications of the 3 main gastro-intestinal cancers: gastric, pancreatic and colorectal adenocarcinoma. In colorectal adenocarcinoma, 6 independent classifications were combined to finally hold 4 molecular sub-groups, Consensus Molecular Subtypes (CMS 1-4), lin...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2016.05.007
更新日期：2016-07-01 00:00:00
abstract：:Paclitaxel is often used as an adjuvant antineoplastic agent. However, very little data is available in literature on its potential genotoxicity on healthy human cells. Our objective is to study the potential in vitro genotoxicity of paclitaxel, by using the cytokinesis-blocked micronucleus assay in combination with f...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：:In medical oncology, how can we be sure that the right drug is being administered to the right patient at the right time? The implementation of quality assurance criteria is important in medical oncology, in order to ensure that the patient receives the best treatment safely. There is very little literature about qual...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2014.1968
更新日期：2014-05-01 00:00:00
abstract：PURPOSES:Analyze the relationship and expectations of cancer patients towards the community pharmacist in a pharmaceutical care coordination project. METHODS:In November 2014, a questionnaire was distributed to ambulatory patients of a university hospital specialized in oncology. Thirteen questions explored the consum...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2017.11.017
更新日期：2018-03-01 00:00:00
abstract：AIM:Harvesting of the "sentinel lymph node" (SLN) as identified by lymphoscintigraphy (LSG) is becoming increasingly important in the staging of patients with malignant melanoma. The purpose of the current study was to determine whether the appearance time of the LSG had a prognostic value in predicting metastasis diss...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:In the French administrative "departement" of Côte-d'Or, between 1982 and 1990, the crude incidence rate and the age-adjusted world standardised incidence rate (ASR) for corpus uteri cancer were respectively 16.0 +/- 0.8 and 10.7 +/- 0.6 per 100,000 women per year. The incidence increased after 50 years of age, reachi...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1994-08-01 00:00:00
abstract：:Seventy five human breast cancers were examined in order to search for the presence of thymidine kinase of the fetal-type (TK-F). The presence of TK-F was evidenced in all tumors. Its activity varied from one to another tumor, but it was evident that the increased TK activity observed in mammary cancers could exclusiv...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Sequencing the human genome brings new tools for the individualisation of cancer chemotherapy, especially thanks to the identification of polymorphisms of genes involved in anticancer drug metabolism or activity (pharmacogenetics). A few functional polymorphisms have been known for a long time (thiopurine methyltransf...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2008.0722
更新日期：2008-10-01 00:00:00
abstract：:Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in France. Recently, colorectal cancer subtyping consortium (CRCSC) identified 4 consensus molecular subtypes (CMS). CMS1 is enriched for CRC with deficient DNA mismatch repair system (dMMR) and tumors with mutated BRAF. Intriguingly, CMS1...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/S0007-4551(15)31220-0
更新日期：2015-06-01 00:00:00
abstract：:Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours and 5 to 10% of struma ovarii. The diagnosis is histologic and retrospective after pelvic surgery; radiographic imaging being unspecific. Because of its rarity, t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2017.11.014
更新日期：2018-03-01 00:00:00
abstract：:In industrialized countries cervical cancer has decreased over the past decades. This, thanks to wide spread screening campaigns of precancerous lesions and microinvasive diseases through regular pap smears starting from the beginning of sexual activity. The diagnostic is realized earlier, thus increasing the rate of ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：:Cells in spleens from tumor bearing animals were found to inhibit in vitro reactivity of lymphocytes to a variety of stimulants. These suppressor cells inhibited the stimulation of normal lymphocytes by mitogens : P.H.A.-Con A-L.P.S. They were adherent cells, bore immunoglobulins at their surface and did not bear the ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：CONTEXT:The "Standards, Options and Recommendations" (SOR) collaborative project was initiated in 1993 by the Federation of the French Cancer Centres (FNCLCC), with the 20 French Regional Cancer Centres, several French public university and general hospitals, as well as private clinics and medical specialty societies. ...
journal_title：Bulletin du cancer
pub_type： 指南,杂志文章,实务指引
doi：
更新日期：2002-04-01 00:00:00
abstract：CAR-T THERAPY:CURRENT USE IN THE UNITED STATES IN 2018: Treatment with T-cells engineered with chimeric antigen receptors (CAR T-cell therapy) has been a field of intense research in the United States since the 1980s. The recent approval in August 2017 of Kymriah (tisagenlecleucel) opened the door to broader access to ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/S0007-4551(19)30052-9
更新日期：2018-12-01 00:00:00
abstract：:Statistical, biological and chemical data on the carcinogenic effect of tobacco smoke are given and are discussed. The epidemiological studies have clearly shown the particularly noxious action of inhalation, and the direct ratio between the risk and the number of cigarettes smoked. The laboratory experiments on biolo...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：INTRODUCTION:Adapted physical activity (APA) is recognized as an effective supportive care for asthenia and quality of life in oncology. Before an APA program was organized, the feasibility of such a program was evaluated among the patients. METHODS:Descriptive, prospective, semi-qualitative, single-center study over ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2017.11.011
更新日期：2018-03-01 00:00:00
abstract：:We report a case of renal cell carcinoma presenting with bilateral adrenal masses diagnosed by ultrasonography four years after nephrectomy. The histopathological examination of the trucut biopsy specimens obtained percutaneously by ultrasound guidance revealed bilateral adrenal mestastases of renal cell carcinoma. ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：:Sentinel lymph node (SLN) biopsy is fast becoming the standard for testing lymph node involvement in many institutions. However questions remain as to stage underestimation. The aim of this study was to analyse this specific risk in a retrospective study. Between 1975 to 1999, 1,636 patients underwent a breast cancer ...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:In a case of glioblastoma, the following karyotype was determined: 47, X, - Y, + der(1) t(1;9)(p21;p23), t(1;9)(p21;p23), + 3, + 7, der(9) t(Y;9)(q11;p21), - 13, t(13;16)(p13,p11), del(14)(q11q22). Classical satellite DNAs are mainly located in chromosomes 1, 9, 15, 16 and Y. Because, most of these chromosomes were im...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Sarcomas are a common type of tumor within the pediatric population. The utilization of proton therapy as a primary attribute the ability to spare adjacent healthy tissue, therefore, proton therapy has become a preferential indication in pediatrics compared to other photon irradiation modalities. Proton therapy is als...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.05.008
更新日期：2018-09-01 00:00:00
abstract：:Malnutrition is frequently observed in oncology. The consequences on patient survival, chemotherapy toxicities and quality of life need to be identified and treated appropriately. A set of tools are available that enable clinicians to diagnose and detect malnutrition. Each tool must consider three items: the patient's...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2016.06.003
更新日期：2016-09-01 00:00:00
abstract：:To have a better understanding of the poor participation rate among general practitioners (GPs) in cervical cancer screening, we have conducted a survey in the department of Bas-Rhin on a small sample of GPs. This helped to explain how they perceived this technical act, the problems or barriers related to it: rate, fu...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:The majority of patients with breast cancer can be treated by partial mastectomy and radiation therapy. The choice of the treatment involves the estimation of the risk for intramammary recurrence and the ability to achieve satisfactory cosmetic result. Patient selection in breast conserving therapy is dependent on cli...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:To establish the recommended dose (RD) of the thymidylate-synthase inhibitor ZD9331 administered with irinotecan (CPT-11) in patients with pretreated metastatic colorectal cancer, and to assess toxicity profile, pharmacokinetics (PK), and anti-tumor activity in a phase I/II open, multicenter, intrapatient ch...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：2004-12-01 00:00:00
abstract：:Breast cancer is the most common cancer among women with more than 53,000 new cases every year in France. The PI3K/AKT pathway is one of the major pathways involved in mammary tumorigenesis. The first effector of this pathway downstream Human Epidermal growth factor Receptor (HER receptors) is the enzyme phosphatidyl-...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2013.1827
更新日期：2013-10-01 00:00:00
abstract：:Urothelial tumors are very rare in children (to date, only about 150 cases have been reported worlwide). Only 20% occur before the age of ten. The aim of this study is to specify the clinicopathologic features of urothelial tumor in young patients, which require a slightly different approach to treatment. On the basis...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2016.11.018
更新日期：2017-02-01 00:00:00
