Abstract:
:Breast cancer is the most common cancer among women with more than 53,000 new cases every year in France. The PI3K/AKT pathway is one of the major pathways involved in mammary tumorigenesis. The first effector of this pathway downstream Human Epidermal growth factor Receptor (HER receptors) is the enzyme phosphatidyl-inositol-3-kinase (PI3K). Some mutations in the gene encoding for the catalytic subunit of this enzyme, the PIK3CA gene, plays an important role, especially in the resistance to targeted therapies used clinically during the last decade. Indeed, the presence of alterations, an overexpression of the PI3K/AKT pathway, or the presence of PIK3CA mutation could explain some resistance to targeted therapies. PIK3CA mutations also appear to have a significant interest in the prediction of response to targeted therapies. Finally, many drugs in development, specifically targeting PI3K or other effectors of the PI3K/AKT pathway are intended to be administered only to patients with tumor bearing a mutation of PIK3CA, which makes the somatic mutations detection more and more important. The aim of this article is to consider biological aspects, clinical significance, diagnostic and theranostic interest of PIK3CA mutations in breast cancer.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Harlé A,Lion M,Lozano N,Merlin JLdoi
10.1684/bdc.2013.1827subject
Has Abstractpub_date
2013-10-01 00:00:00pages
947-54issue
10eissn
0007-4551issn
1769-6917pii
S0007-4551(15)30202-2journal_volume
100pub_type
杂志文章abstract::We have examined the effect of cyclosporin A on transport processes (uptake, efflux, binding) of mitoxantrone in isolated rat liver cells. Accumulation and binding of mitoxantrone was rapid with or without cyclosporin A. The initial uptake was linear over a wide concentration range (1 to 1000 microM). For the first 10...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::In order to understand the kinetics of this experimental model, we studied the influence of age and sex on primary tumoral and pulmonary metastatic yields and on the growth kinetics parameters. Connective tissue tumors were induced by DMBA in male and female Swiss mice of various ages (pre and postpubertal, adult and ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Oral cavity and pharyngeal cancers account for 75% of head and neck cancers and are the fourth most spread cancer in men. Their incidence has decreased since 1980 in men (incidence from 2011 gives 13,930 for lip, oral cavity, pharyngeal and laryngeal carcinomas) but has increased in women, linked to the more recent sm...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2014.1962
更新日期:2014-05-01 00:00:00
abstract::Breast cancer remains a potentially lethal disease, which requires aggressive treatments and is associated with long-term consequences. Its prognosis is linked to both tumor biology and burden at diagnosis. Although treatments have allowed important improvements in prognosis over the past 20 years, breast cancer scree...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2016.06.005
更新日期:2016-09-01 00:00:00
abstract:CONTEXT:The "Standards, Options and Recommendations" (SOR) collaborative project was initiated in 1993 by the Federation of the French Cancer Centres (FNCLCC), with the 20 French Regional Cancer Centres, several French public university and general hospitals, as well as private clinics and medical specialty societies. ...
journal_title:Bulletin du cancer
pub_type: 指南,杂志文章,实务指引
doi:
更新日期:2002-04-01 00:00:00
abstract:INTRODUCTION:Few studies have explored the long-term occupational situation after cancer. The aim of our study were to study the employment status among long-term cancer survivors and to compare it to cancer-free controls from the general population at 5, 10 or 15 years after cancer diagnosis. METHODS:From data of a r...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2020.06.004
更新日期:2020-09-01 00:00:00
abstract::Estrogen receptor determinations were performed on 241 cytosols from 160 breast cancer tumors, using both dextran coated charcoal method (D.C.C.) and monoclonal antibodies (Abbott's ER-EIA kit) in order to compare the two methods, and to evaluate the clinical usefulness of this new immunological simplified assay. Intr...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::It is not apparent that advanced human carcinomas of the breast or the large bowel are conprised of at least two populations: those responding to treatment with 5-fluorouracil (approximately 20 per cent) and those unresponsive to this drug. This classification cannot be made before chemotherapy on the basis of any cli...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::A retrospective, morphological and immunochemical study was performed on 60 bone marrow biopsies (BOM) and 12 tumor specimens surgically excised, from 9 patients with neuroblastoma (NB). Immunochemistry concerned "neuron-specific enolase" (NSE), chromogranin A (CGA) and synaptophysin (SP). The results of immunochemica...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Minimal invasive surgery and reconstructive surgery tend to become the standard in France in the management of head and neck tumors. The use of endoscopic approaches (through endoscopic endonasal/transoral approaches±robot-assisted) instead of open surgery and the use of reconstructive surgery using autologous (flaps)...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2020.04.011
更新日期:2020-01-01 00:00:00
abstract::Phase III clinical trials (CT) are carried out more and more often in a multicentric way, under the aegis of one or more cooperative groups (CG). The goal of this study was to analyze the influence of the GC on ethical quality (EQ) and methodological quality (MQ) in phase III cancer CT. EQ (Berdeu-score) and MQ (Jadad...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::The endothelins (ET1, ET2, ET3) are a family of peptides that exert vasoactive and mitogenic effects. ETs bind to at least two subtypes of receptors: the ETA subtype is ET1 selective whereas the ETB subtype binds ET1, ET2 and ET3. By RT-PCR, we detected ETA receptor mRNA and ETB receptor mRNA in leiomyoma and in homol...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::In 2003, there was 147,000 deaths attributed to cancer in France, 88,000 in men and 59,000 in women. Cancer mortality rates have been decreasing since 1987 in the male population and since the late 60's in the female population, the decrease is larger for the male population. This decrease is observed for most sites o...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Results from case-control studies and prospective studies suggest that diet is involved in the causation of large bowel cancer either as initiator, promoter or inhibitor of carcinogenesis. Available data are not sufficient to serve as a basis for firm specific dietary advice. In the present situation it is attractive ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::Ten years after the discovery of the predictive value of KRAS status for anti-EGFR antibodies, other genes involved in oncogenesis and therapeutic responses were identified and are now systematically sought. Molecular diagnosis often requires invasive procedures, sometimes iatrogenic, and is limited by feasibility pro...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2015.10.017
更新日期:2016-01-01 00:00:00
abstract::Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in France. Recently, colorectal cancer subtyping consortium (CRCSC) identified 4 consensus molecular subtypes (CMS). CMS1 is enriched for CRC with deficient DNA mismatch repair system (dMMR) and tumors with mutated BRAF. Intriguingly, CMS1...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/S0007-4551(15)31220-0
更新日期:2015-06-01 00:00:00
abstract::Macroautophagy or autophagy is a degradative pathway terminating in the lysosomal compartment after the formation of a cytoplasmic vacuole that engulfs macromolecules and organelles. The recent discovery of the molecular controls of autophagy that are common to eukaryotic cells from yeast to human suggests that the ro...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:2006-05-01 00:00:00
abstract:CONTEXT:The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of French Cancer Centers (FNCLCC), the 20 French Cancer Centers, and specialists from French Public Universities, General Hospitals and Private Clinics. The main objective is the development of...
journal_title:Bulletin du cancer
pub_type: 指南,杂志文章,实务指引
doi:
更新日期:2002-02-01 00:00:00
abstract::The rising incidence of cancers affecting the kidney emphasizes the need to identify the molecular pathways involved in the initiation and progression of kidney tumors in order to counter this phenomenon. For many years, genes belonging to the PAX family have been the focus of intensive studies in the fields of organo...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:2006-09-01 00:00:00
abstract::Receptor assays for both ER and PR in breast cancer specimens is used either to choose adjuvant therapy during the first treatment, or to choose hormone therapy for metastatic patients, or for the diagnosis of tumors. Whereas biochemical methods, either by radioligand or by monoclonal antibodies, have progressed over ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::This study is concerning 70 patients (57 female, 13 male) with an epidermoid carcinoma of the anal canal which were treated homogeneously with a combination of an external beam radiation therapy ((45 Gy in 25 fractions of 1.8 Gy for 5 weeks) and a brachytherapy with Iridium wires (15 to 20 Gy delivered to the gross re...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::Although cytotoxic chemotherapy is the main therapeutic option to treat gastric cancer in the metastatic setting, molecular targeted agents have recently been introduced in an effort to improve survival outcomes which in average do not exceed 1 year. Trastuzumab and ramucirumab, antibodies directed against HER2 and VE...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2018.07.012
更新日期:2018-10-01 00:00:00
abstract::mdm2 (mouse double minute) protein seems lead to p53 inactivation and therefore might potentially play a role in carcinogenesis. We have studied mdm2 gene amplification from 239 primary breast cancer tissues. mdm2 gene was amplified in 10% of cases (25/239). mdm2 amplification was associated with c-erbB2 amplification...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Understanding medical practices or the whys and wherefores of care decision-making is among the major objectives of medical, economic and sociological research in the current political environment. Although variations of medical practice have long been known to exist, causes and deciding factors remain obscure. This i...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:2006-02-01 00:00:00
abstract::The authors report their ultrastructural findings of 36 involved lymph-nodes in Hodgkin's disease (HD), before any treatment. More than 400 tumour cells were studied. An analytical study was carried out on the different aspects presented by the nuclei (uni or multi-lobated); the nucleoli (compact, reticulate or disper...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::We have treated in 1990 and 1991, 84 arteriovenous malformations (AVMs) by radiosurgery. Irradiation was realized by 5 to 7 arcs with 15 MV X rays circular minibeams of a GE-CGR Saturne 43 Linac diameter, at 100 cm 6 to 20 mm; the Betti arm chair and the Talairach frame. The prescribed peripheral dose containing the n...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:1995-12-01 00:00:00
abstract::Angiopoietin-2 is a new member of the family of the ligands of Tek (Tie2), a transmembrane receptor with tyrosine kinase activity which is specifically expressed in endothelial cells during angiogenesis. Several lines of evidence indicate that angiopoietin-1 is involved in pericyte recruitment by endothelial cells and...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract::The aims of this study was to estimate and describe the reasons of use of complementary medicine in patients with a cancer treated in a French oncology department. An anonymous questionnaire was proposed to patients during treatment or follow-up in an oncology department. It was a descriptive study over 207 questionna...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::Recommendations for the management of gastrointestinal stromal tumours (GIST) in children and adolescents do presently not exist. Thus, a summary of the current literature was conducted serving as a basis for the development of optimal management strategies for childhood GIST. Pediatric cases of GIST may occur sporadi...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2010.1296
更新日期:2011-01-01 00:00:00
abstract::In a case of glioblastoma, the following karyotype was determined: 47, X, - Y, + der(1) t(1;9)(p21;p23), t(1;9)(p21;p23), + 3, + 7, der(9) t(Y;9)(q11;p21), - 13, t(13;16)(p13,p11), del(14)(q11q22). Classical satellite DNAs are mainly located in chromosomes 1, 9, 15, 16 and Y. Because, most of these chromosomes were im...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00