Abstract：
:Cells in spleens from tumor bearing animals were found to inhibit in vitro reactivity of lymphocytes to a variety of stimulants. These suppressor cells inhibited the stimulation of normal lymphocytes by mitogens : P.H.A.-Con A-L.P.S. They were adherent cells, bore immunoglobulins at their surface and did not bear the 0 marker. They were also demonstrated in T deprived tumor bearing animals. They might be B cells, or, more probably, macrophages. Other activities that are inhibited by the suppressor cells are: -reactivity to allogenic cells in the mixed lymphocyte culture, -in vitro generation of secondary anti tumor cytotoxic effector cells, -macrophage migration inhibition in the presence of immune lymphocytes and tumor extracts, -reactivity against syngeneic tumor cells or tumor extracts. Suppressor cells may play a role in the general immunodepression of tumor bearing hosts, and in the inability of tumor bearing hosts to reject the tumor. However, the biological role of these non T suppressor cells is not clear, as they also inhibit tumor cell growth, and in vivo experiments favour suppressor cells of thymic origin.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Lespinats G,Poupon MFsubject
Has Abstractpub_date
1976-04-01 00:00:00pages
269-78issue
2eissn
0007-4551issn
1769-6917journal_volume
63pub_type
杂志文章abstract：:In 2003, there was 147,000 deaths attributed to cancer in France, 88,000 in men and 59,000 in women. Cancer mortality rates have been decreasing since 1987 in the male population and since the late 60's in the female population, the decrease is larger for the male population. This decrease is observed for most sites o...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Should we consider surgery for pancreatic cancer when resectability seems initially uncertain? The answer is no consensual as illustrated by the controversy presented here. This article presents the key arguments against surgery. ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/S0007-4551(15)31231-5
更新日期：2015-06-01 00:00:00
abstract：:Twenty-five adult patients, 15 men and 10 women, with a median age of 49, and presenting with metastatic or locally advanced soft tissue sarcomas, have been treated with chemotherapy protocol combining cisplatinum, 100 mg/m2, vindesine, 4 mg/m2, and either adriamycin, 50 mg/m2 (APEL) (16 patients), or epirubicin, 100 ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The first study evaluating directly by the referring physician the clinical impact of [18F]-FDG-PET on modification of patient's management was performed only recently in California by means of a questionnaire. We have used the same methodology to evaluate this clinical impact during the opening year of our PET centre...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:The high rate of recurrence after apparently complete surgery and/or complete clinical response to chemotherapy implies that most patients have undetected minimal residual disease. Novel techniques such as laparoscopic or laparotomic fluorescence may prove to be crucial in reassessing the definition of primary outcome...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2013.1730
更新日期：2013-04-01 00:00:00
abstract：:All the retrospective and prospective studies concerning IORT in tumors of the digestive tract tend to substantiate a significant improvement in local control without a significant increase in survival. Improvements in the results of IORT can be expected in the near future, and may occur on several fronts: - Technolog...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2001-02-01 00:00:00
abstract：:The radiobiological properties of the hadrons (neutrons, protons, carbon ions) led to their therapeutic use in sarcomas, as a referent therapy or as an alternative to photon therapy. An extensive review of the literature has been conducted to assess the present indications and the perspectives for hadrontherapy. Compa...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1125
更新日期：2010-06-01 00:00:00
abstract：:Endometrial cancer is a common cancer in older women and is often associated with comorbidities. Management of metastatic disease and/or relapse requires a multidisciplinary approach. Recent advances in the understanding of oncogenesis and molecular classification of endometrial cancers offer new therapeutic perspecti...
journal_title：Bulletin du cancer
pub_type： 杂志文章,实务指引
doi：10.1016/j.bulcan.2020.06.006
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:A high prevalence of renal insufficiency has been observed in cancer patients as well as a high incidence of de novo cancer in dialysis or renal transplant patients. MATERIAL AND METHODS:We aimed to determine the incidence of cancer in patients under dialysis and in kidney transplant recipients through a se...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2012.1545
更新日期：2012-03-01 00:00:00
abstract：:This article briefly outlines three major biochemical problems in relation to the presence of chemical carcinogens in mammalian cells: (a) the enzymatic systems responsible for the chemical carcinogen metabolism; (b) the nature of the reactive metabolites and (c) the cellular target(s). References and examples are onl...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:This survey, conducted in region Rhône-Alpes (France), aims to assess some data in thoracic oncology practice including availability of specialized equipments. This study is based on a questionnaire mailed to oncologists and pulmonologists in the region. Of 401 questionnaires, the response rate was 56%. Responses of 7...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2011.1366
更新日期：2011-06-09 00:00:00
abstract：:Angiogenesis plays an important role in the progression of tumors. This relationship has been described in several hematologic malignancies. Vascular endothelial growth factor and basic fibroblast growth factor are predictors of poor prognosis in leukemia and non Hodgkin's lymphoma. Bone marrow microvessels were found...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2007-07-01 00:00:00
abstract：:Advances in early detection and treatment have pushed in a few decades the management of cancers from a management model of the end of life to the management of a chronic disease. This evolution has accelerated the development of supportive care in two directions, firstly towards the best possible support to the end o...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.04.007
更新日期：2018-09-01 00:00:00
abstract：:Although cytotoxic chemotherapy is the main therapeutic option to treat gastric cancer in the metastatic setting, molecular targeted agents have recently been introduced in an effort to improve survival outcomes which in average do not exceed 1 year. Trastuzumab and ramucirumab, antibodies directed against HER2 and VE...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.07.012
更新日期：2018-10-01 00:00:00
abstract：:Recommendations for the management of gastrointestinal stromal tumours (GIST) in children and adolescents do presently not exist. Thus, a summary of the current literature was conducted serving as a basis for the development of optimal management strategies for childhood GIST. Pediatric cases of GIST may occur sporadi...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1296
更新日期：2011-01-01 00:00:00
abstract：:Localization of the sentinel lymph node (SLN) in digestive cancers was performed mainly for colorectal primaries and less frequently for oeso-gastric primaries. This technique is feasible in vivo or ex vivo, with a vital dye and/or with a radiolabeled marker. Technically, detection reliability is good, provided a few ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-06-01 00:00:00
abstract：:Androgen deprivation in patients with metastatic prostate cancer produces palliation of symptoms, PSA decrease and tumoral regression in most patients. After a brief period of disease regression lasting 18 to 24 months nearly all pts will progress to androgen independence disease (HRPC) with progressive clinical deter...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2007-07-01 00:00:00
abstract：:An increasing number of clinicians is to day aware of the need to assess their diagnostic tools. Despite the fact that monetary value is only one of the components of the cost of a diagnostic test, economical problems are decisive stimuli for such an effort. Any diagnostic test involves a cost which is borne by the pa...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The higher human and material costs induced by the development of conformal radiotherapy and other innovative techniques have to be evaluated. Different studies reflect benefit for three-dimensional conformal radiation therapy. This needs appropriate economic analyses (cost/benefit, cost/utility). Conclusions from stu...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:Angiopoietin-2 is a new member of the family of the ligands of Tek (Tie2), a transmembrane receptor with tyrosine kinase activity which is specifically expressed in endothelial cells during angiogenesis. Several lines of evidence indicate that angiopoietin-1 is involved in pericyte recruitment by endothelial cells and...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：:Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours and 5 to 10% of struma ovarii. The diagnosis is histologic and retrospective after pelvic surgery; radiographic imaging being unspecific. Because of its rarity, t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2017.11.014
更新日期：2018-03-01 00:00:00
abstract：:Primary chemotherapy is the use of anticancer drugs as the first treatment in patients with localized tumor presentations for which there is an alternative but less than satisfactory treatment. Its most important feature is the preservation of the primary tumor mass as a biologic marker of response, and in this sense ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
abstract：:This review will describe the current knowledge in the pathophysiology, diagnosis, prognosis and treatment of pulmonary MALT (Mucosa Associated Lymphoid Tissue) lymphoma. Pulmonary MALT lymphomas are low-grade B cell lymphoma and are the most frequent lymphomas arising from the lung. Tumour cells arise from mucosa ass...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2014.1885
更新日期：2014-02-01 00:00:00
abstract：:In this review, we will summarize the guidelines on the evaluation of anticancer medicinal products in man and definitions for genomic biomarkers (FDA validated), pharmacogenomics, pharmacogenetics, genomic data and sample coding categories. ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2008.0733
更新日期：2008-10-01 00:00:00
abstract：:Protein phosphorylation is a fundamental post-translational modification. It regulates a large number of critical cellular processes (differentiation, division, proliferation, apoptosis). Cell division is a process including a series of phases by which a parent cell divides into two daughter cells. The cells enter the...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2011.1383
更新日期：2012-02-01 00:00:00
abstract：:Hodgkin's and non-Hodgkin's lymphomas are frequent and represent a heterogenic group of haematologic diseases. Prognostic factors allow to classify patients into homogeneic risk groups, to adapt treatment proposal to disease's risk and, in some cases, to avoid over-treatment. For all lymphomas, the first step is to de...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2009.0844
更新日期：2009-04-01 00:00:00
abstract：:The effects various drugs exert on antioxidant enzyme and glyoxalase activity in rat livers were studied. All drugs tested provoked a marked reduction in glutathione peroxidase and a small drop in both glyoxalase I and II activity. It is hypothesized that the substances tested support tumour development by neutralizin...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:The biological diagnosis of prostatic carcinoma in relation with benign prostatic hypertrophy is essentially realized by the evaluation of plasma PAP or medullar PAP, the increase of which rises to 70% of the cases. This evaluation contains also other biochemical markers such as CK-BB, glucose-6-phosphate dehydrogenas...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The authors report their ultrastructural findings of 36 involved lymph-nodes in Hodgkin's disease (HD), before any treatment. More than 400 tumour cells were studied. An analytical study was carried out on the different aspects presented by the nuclei (uni or multi-lobated); the nucleoli (compact, reticulate or disper...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:We evaluated the efficacy and safety of a monotherapy by piperacillin and sulbactam potentially associated to vancomycin as an empiric antimicrobial therapy in febrile neutropenic patients treated with nephrotoxic chemotherapy for solid tumors. Twenty-three patients were treated during 32 episodes with piperacillin 4 ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
