[Biological bases for individualising prescriptions in oncology: the germline genome].

Abstract:

:Sequencing the human genome brings new tools for the individualisation of cancer chemotherapy, especially thanks to the identification of polymorphisms of genes involved in anticancer drug metabolism or activity (pharmacogenetics). A few functional polymorphisms have been known for a long time (thiopurine methyltransferase, glutathion S-transferases), but several new ones have been identified recently, at the level of the genes encoding drug targets (thymidylate synthase), at the level of DNA repair enzymes (XPD) or at the level of transport proteins (MDR1). Clinical trials, first on a retrospective basis, then on a prospective one, are implemented to validate this approach.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Robert J,Le Morvan V

doi

10.1684/bdc.2008.0722

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

911-21

issue

10

eissn

0007-4551

issn

1769-6917

pii

bdc.2008.0722

journal_volume

95

pub_type

杂志文章
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  • [Recognition of occupational cancers: review of existing methods and perspectives].

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  • [Tumor-stroma interactions].

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  • [SOR SAVOIR PATIENT Cancer and fatigue. Information dedicated to cancer patients and relatives].

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  • [Secondary non-Hodgkin's lymphomas].

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  • [Effectiveness of a supportive care form for family physicians].

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  • [Angiogenesis targeting in renal carcinomas].

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Pouessel D,Culine S

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  • [Primary prevention of colorectal cancer].

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    doi:

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    doi:

    authors: Maubant S,Staedel C,Gauduchon P

    更新日期:2002-11-01 00:00:00

  • [Gangliosides and cancer].

    abstract::Gangliosides are glycosphingolipids which contain neuraminic acid. Although they are present in the plasma membranes of all cells, gangliosides are expressed differently, both quantitatively and qualitatively, in certain types of cancer. Modifications in ganglioside composition may account for some of the abnormal int...

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    doi:

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    doi:

    authors: Bates SE,Regis JI,Robey RW,Zhan Z,Scala S,Meadows BJ

    更新日期:1994-12-01 00:00:00

  • [Ondansetron: a specific 5-HT3 serotonin receptor inhibitor, a new antiemetic in oncology].

    abstract::Serotonin (5-Hydroxytryptamine) seems to play a dominant role in triggering vomiting induced by cytotoxic agents through the stimulation of 5-HT3 receptors. They have been observed in the GI tract as well as in the brain (area postrema). Ondansetron is a specific antagonist of 5-HT3 serotonin receptors. Its anti-emeti...

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    pub_type: 杂志文章,评审

    doi:

    authors: d'Allens H,Aubert B,Bons J,Pappo M

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Yerushalmi A

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  • [Cytotoxicity of tamoxifen and its principal metabolites in human breast cancer cell lines].

    abstract::The antiestrogen tamoxifen (TAM) has been successfully used to treat breast cancer expressing estrogen and progesterone receptors (ER+ and PR+). However, the development of antiestrogen resistance is frequently observed in patients following long-term treatment. To better understand the mechanism of action of TAM and ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Bachmann-Moisson N,Barberi-Heyob M,Merlin JL,Ledrich ML,Batt AM,Guillemin F

    更新日期:1996-10-01 00:00:00

  • [Individualized anticancer therapies: which regulatory guidelines?].

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    doi:10.1684/bdc.2008.0733

    authors: Bedairia N,Marty M

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  • [Proton therapy in soft tissue and bone sarcomas].

    abstract::Sarcomas are a common type of tumor within the pediatric population. The utilization of proton therapy as a primary attribute the ability to spare adjacent healthy tissue, therefore, proton therapy has become a preferential indication in pediatrics compared to other photon irradiation modalities. Proton therapy is als...

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