Abstract：
:Improved techniques for inducing heat: ultrasound, microwaves, diathermy with different application modalities, capable of producing localized superficial or deep, regional or total body hyperthermia have been responsible for the multiplication of clinical trials. These studies have confirmed the tumoricidal effect of hyperthermia alone, or more especially when combined with radiotherapy, and the good tolerance of normal tissues to localized temperatures of 42 to 43.5 degrees C even in previously irradiated cases. Localized heating does not seem to increase the incidence of metastasis. Enhancement ratios and therapeutic gain with respect to normal tissues are not yet well documented. Many problems, including the heterogenicity of tissues to be heated, difficulties with temperature monitoring, and selection of appropriate sequential scheduling of radiation and hyperthermia remain unsolved and further investigations are required.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Jaulerry C,Bataini JP,Brunin F,Gaboriaud Gsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
261-7issue
3eissn
0007-4551issn
1769-6917journal_volume
68pub_type
杂志文章,评审abstract：:Blood glucose levels were temporarily elevated in normal and in tumor bearing Lewis rats subjected to one local hyperthermic treatment in the leg or in the upper abdomen. Serum transferred from locally heated animals or serum heated in-vitro and injected to normal recipients resulted in elevated blood glucose levels. ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:All the retrospective and prospective studies concerning IORT in tumors of the digestive tract tend to substantiate a significant improvement in local control without a significant increase in survival. Improvements in the results of IORT can be expected in the near future, and may occur on several fronts: - Technolog...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2001-02-01 00:00:00
abstract：:Paclitaxel is often used as an adjuvant antineoplastic agent. However, very little data is available in literature on its potential genotoxicity on healthy human cells. Our objective is to study the potential in vitro genotoxicity of paclitaxel, by using the cytokinesis-blocked micronucleus assay in combination with f...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：:Having to start chemotherapy during pregnancy remains a rare event. The decision to proceed this treatment relies on the drugs used, the time of exposure for the foetus and the gestational age at the time of exposure. As a matter of fact, the mutagenicity potential of the chosen medicine has to be known, and consequen...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:The discovery of oncogenes and tumor suppressors has established the original concept of cancer development based on a cascade of spontaneously occurring somatic mutations. It is now well known that genomes of cancer cells are deeply rearranged and that these rearrangements have devastating consequences on their organ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1200
更新日期：2010-11-01 00:00:00
abstract：:Gemcitabine has demonstrated a good efficacy in number of tumor types. Thanks to its favourable toxicity profile, gemcitabine can be used in combination with a number of drugs. Single agent gemcitabine and gemcitabine-based combinations have been evaluated in metastatic breast cancer. Some of these combinations, such ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-08-01 00:00:00
abstract：:The anticancer drug technical commission (COTECH) of the Auvergne OMEDIT has set up a region-wide professional practice evaluation (PPE) with regards to antiemetic prescription practices in chemotherapy-induced nausea and vomiting (CINV), in order to evaluate their compliance with OMEDIT's guidelines. Are not included...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2016.03.009
更新日期：2016-07-01 00:00:00
abstract：:Alveolar soft part sarcoma, ASPS, is a rare malignant tumor, with preferential primary localization in limbs, usually occurring in adolescents and young adults. This sarcoma, well defined histologically and at molecular level, has an indolent course, but a high potential metastatic pulmonary and cerebral evolution, so...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2015.05.004
更新日期：2015-09-01 00:00:00
abstract：:Integrins are a family of heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix adhesion. Integrin-mediated signaling is essential for the regulation of fundamental cellular functions, including proliferation and survival, and for tumor development. According to in vitro studies, i...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
abstract：:Glioblastoma multiforme still remains, at present, the most frequent and deadly primary malignant glioma in adult. Despite safer and larger neurosurgical resections, patients almost always relapse very close or inside the tumor bed. Since more than 20 years, radiation therapy (RT) continue delivering the same dose of ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:The standard treatment in first line of advanced or metastatic urothelial bladder cancer (MBC) is the association of Gemcitabine and Cisplatin (GC). Avelumab, an anti-PD-L1 agent, has recently demonstrated efficacy. The objective is to evaluate the combination of these 3 agents. METHODS:This phase II random...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/S0007-4551(20)30280-0
更新日期：2020-06-01 00:00:00
abstract：INTRODUCTION:Adolescents and young adults (AYA, 15-25years old) with cancer are treated either in adult or pediatric units. Management of febrile neutropenia (FN) is different between these units. Monitoring rules and indications of hospitalization are often stricter in pediatrics. This study evaluates if these differe...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2015.08.001
更新日期：2015-11-01 00:00:00
abstract：:Recommendations for the management of gastrointestinal stromal tumours (GIST) in children and adolescents do presently not exist. Thus, a summary of the current literature was conducted serving as a basis for the development of optimal management strategies for childhood GIST. Pediatric cases of GIST may occur sporadi...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1296
更新日期：2011-01-01 00:00:00
abstract：:From July 1987 to July 1988, 35 patients with non small cell lung cancer, stage IV, were included in a phase II trial (GLOT NPC 87/01). The treatment was as follows: cisplatin 50 mg/m2 day 1, vindesin 3 mg/m2 day 1, mitomycin 6 mg/m2 day 2, and bleomycin 15 mg/day, day 1 + 2 by continuous infusion. The evaluation for ...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-01-01 00:00:00
abstract：:Sixty percent of cancer patients have or develop bone metastases during the development of their cancer. Bone metastases are the most common cause of cancer-related pain. External radiation therapy is the standard treatment of uncomplicated bone metastases, for the treatment of pain, the prevention of fracture, and fo...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2013.1845
更新日期：2013-11-01 00:00:00
abstract：:Irinotecan (CPT11), a topoisomerase I inhibitor, is a new cytotoxic agent with a broad spectrum of clinical activity. Two main schedules have been studied and produce similar activity and side-effects: the "european" one--350 mg/m2 every 21 days-, and the "japanese-north american" one where CPT11 is given at a weekly ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1998-12-01 00:00:00
abstract：:Phase III clinical trials (CT) are carried out more and more often in a multicentric way, under the aegis of one or more cooperative groups (CG). The goal of this study was to analyze the influence of the GC on ethical quality (EQ) and methodological quality (MQ) in phase III cancer CT. EQ (Berdeu-score) and MQ (Jadad...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：:Between October 1987 and June 1992, 244 patients with metastatic renal carcinoma were referred to our Institute. One hundred and sixty-nine were included in immunotherapy protocols. The 40 most recent patients were included in the ongoing multicentric randomised Crecy study. The previous patients were treated with IL2...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-07-01 00:00:00
abstract：:Sarcomas are a common type of tumor within the pediatric population. The utilization of proton therapy as a primary attribute the ability to spare adjacent healthy tissue, therefore, proton therapy has become a preferential indication in pediatrics compared to other photon irradiation modalities. Proton therapy is als...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.05.008
更新日期：2018-09-01 00:00:00
abstract：:Advances in medical imaging have greatly enhanced the speciality of radiation oncology by allowing more healthy tissue to be speared for better tumour coverage. Positron emission tomography (PET) with the glucose analogue [18F]-fluoro-2-deoxy-D-glucose (FDG) is a functional imaging method that has become widely used i...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:At the time of diagnosis, central nervous system (CNS) involvement is identified in less than 10% of adult acute lymphoblastic leukemia (ALL). Long-term disease-free survival can be achieved in these patients. CNS disease at presentation does not appear to be an independent poor prognostic factor. In CNS leukemia, inn...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2008.0645
更新日期：2008-07-01 00:00:00
abstract：:Adjuvant chemotherapy after apparently complete resection of gastrointestinal cancer may be theoretically justified by the high rate of local and metastatic recurrences. However, the results of controlled trials are generally disappointing, even if some of them have recently suggested some hope, chiefly for adjuvant t...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:EXPRESSION III was designed to evaluate the information, needs and expectations of patients with ovarian cancer in different European countries. This abstract focuses on specific results from French OC patients. Two hundred and fifty-seven patients filled a 27-item questionnaire during a medical visit. Median age rang...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2014.09.004
更新日期：2015-03-01 00:00:00
abstract：:Originally described for its capacity to induce hemorrhagic necrosis of transplantable tumors in mice, TNF-alpha also exerts cytotoxic effects against some tumor cell lines in vitro. It is now known that TNF is an essential mediator of cellular immunity and a wide variety of biological activities of TNF in vitro and i...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:The association between cancer and dependence was estimated using a cross-sectional study among persons 75 years of age or-older in Tarn county (area with a cancer registry recognized by the National Committee of Registries). A representative random sample stratified on age, sex, and size of district, was drawn using ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：:Hodgkin's and non-Hodgkin's lymphomas are frequent and represent a heterogenic group of haematologic diseases. Prognostic factors allow to classify patients into homogeneic risk groups, to adapt treatment proposal to disease's risk and, in some cases, to avoid over-treatment. For all lymphomas, the first step is to de...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2009.0844
更新日期：2009-04-01 00:00:00
abstract：:Conservative management of at least a part of one ovary and the uterus, in order to preserve fertility-potential, could be propose in most of patients with nonepithelial and borderline ovarian tumor. This conservative management could be performed even in patients with borderline ovarian tumor associated with noninvas...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：:The epithelial-mesenchymal transition (EMT) is a morphogenetic program that converts epithelial into mesenchymal cells during the embryonic development. This mechanism is frequently reactivated during tumor progression and provides cells with motility and invasive capabilities favoring the metastatic dissemination fro...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2009.1025
更新日期：2010-01-01 00:00:00
abstract：:A retrospective, morphological and immunochemical study was performed on 60 bone marrow biopsies (BOM) and 12 tumor specimens surgically excised, from 9 patients with neuroblastoma (NB). Immunochemistry concerned "neuron-specific enolase" (NSE), chromogranin A (CGA) and synaptophysin (SP). The results of immunochemica...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Malnutrition is frequently observed in oncology. The consequences on patient survival, chemotherapy toxicities and quality of life need to be identified and treated appropriately. A set of tools are available that enable clinicians to diagnose and detect malnutrition. Each tool must consider three items: the patient's...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2016.06.003
更新日期：2016-09-01 00:00:00
