Abstract:
OBJECTIVE:Children with chronic kidney diseases (CKD) are at risk for neurological diseases at early adulthood. Spectral-domain optical coherence tomography (SD-OCT) of the retina is especially suitable for determination of intraretinal layer thickness. We wonder whether retinal thinning is already present in pediatric patients with mild-to-moderate CKD. PATIENTS AND METHODS:Children (n = 15; 14.9 ± 2.4 years) with mild-to-moderate CKD (median eGFR of 95ml/min/1.73m2; range: 28-187ml/min/1.73m2) due to glomerulopathy, congenital anomalies of kidney and urinary tract (CAKUT), or haemolytic uremic syndrome (HUS) underwent a detailed ophthalmologic examination including high-resolution SD-OCT. Three OCT scans were obtained from the right eyes of all patients. Within each scan, retinal layers were separated and the mean thickness was determined at the foveal, parafoveal, and perifoveal area. The results were compared to those we obtained previously from healthy children. RESULTS:At the parafoveal area, thickness (median, range) of the total retina (ALL), ganglion cell layer (GCL), and inner plexiform layer (IPL) were reduced compared to healthy volunteers (339µm, (288-361µm) vs. 348µm, (320-385µm); 49.8µm (30.5-56.6µm) vs. 53.5μm (49.5-60.5µm) and 41.0µm (29.4-43.7µm) vs. 43.46µm (39.5-46.3μm); each p < 0.05). The intraretinal thickness measurements at the foveal and perifoveal areas revealed no statistically significant differences between patients and controls. CONCLUSION:Distinct changes within the parafoveal area of the total retina, GCL, and IPL are present in children with mild-to-moderate CKD. Prospective studies are required to assess the clinical significance of our findings.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Prakasam RK,Götze A,von Keyserlingk S,Jünemann A,Röhlig M,Stachs O,Fischer DCdoi
10.1080/02713683.2018.1522649subject
Has Abstractpub_date
2019-02-01 00:00:00pages
206-211issue
2eissn
0271-3683issn
1460-2202journal_volume
44pub_type
杂志文章abstract:PURPOSE:Transplantation of in vitro cultured limbal epithelial stem cells (LESCs) is a treatment widely used for LESC deficiency. However, the number of limbal tissue donors is limited, and protocols for LESC cultivation often include compounds and/or feeder layers that can induce side effects and/or increase the cost ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1250278
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To determine the role of apoptosis in the pathogenesis of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. METHODS:Forty-three eyes from patients with cytomegalovirus retinitis treated before the introduction of highly active anti-retroviral therapy were examined by routine hi...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:AIM:To compare patient satisfaction and experience after external dacryocystorhinostomy (EX-DCR) versus transcanalicular DCR (TC-DCR) with a diode laser and to evaluate the change in quality of life following simultaneous bilateral DCR. METHODS:Prospective evaluation of 38 eyes of 19 patients with bilateral nasolacrim...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.658488
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:The purpose of this work is to describe and review the technology of plasma rich in growth factors (PRGF), a novel blood derivative product, in the treatment of ocular surface disorders. METHODS:To demonstrate the importance of this technology in the treatment of ocular pathologies, a thorough review of the pr...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713683.2015.1104362
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To evaluate how patient satisfaction after cataract surgery is associated with postoperative visual acuity, visual functioning, dry eye signs and symptoms, health anxiety, and depressive symptoms. PATIENTS AND METHODS:Fifty-four patients (mean age: 68.02 years) were assessed 2 months after uneventful phacoemul...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1262429
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine the retinal expression of angiogenic chemokines/cytokines in a mouse model of oxygen-induced retinopathy. METHODS:C57BL/6 (B6) mice were exposed to 75% oxygen from postnatal day 7 (P7) to P12 and then recovered in room air. Reverse transcription-polymerase chain react...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680590923276
更新日期:2005-04-01 00:00:00
abstract::An isopter of visual field charted using the Goldmann perimeter represents a conical area of visual space whose apex is at the eye of the subject and whose base intersects the hemispherical surface of the perimeter bowl. Conventional isopter plotting conceals cartographic distortion and leads to serious underestimates...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109001732
更新日期:1981-01-01 00:00:00
abstract:PURPOSE OF THE STUDY:To assess differences in healthy eyes in volume (CV) and choroidal thicknesses (CT) across all macular Early Treatment Diabetic Retinopathy Study (ETDRS) areas measured by swept source (SS)-OCT and spectral domain (SD)-OCT with enhanced depth imaging (EDI). MATERIALS AND METHODS:One hundred and fi...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1795883
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:To investigate whether retinal impairment was affected by age of rats in acute glaucoma model. METHODS:Young adult and aged rats were randomly divided into normal control, 45 mmHg, 60 mmHg and 90 mmHg groups. Intraocular pressures (IOP) of rats were acutely elevated to 45 mmHg, 60 mmHg and 90 mmHg, respectivel...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.922194
更新日期:2015-03-01 00:00:00
abstract::Two alternative methods for the study of the lens cytoskeleton are described which serve to overcome some of the difficulties imparted by the unique biology of the lens. The first technique involves rapid freezing, thick sectioning, and selective extraction and/or fixation of the lens section. This approach offers sev...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008997582
更新日期:1990-11-01 00:00:00
abstract::To investigate the role of lymphocytes in the pathogenesis of uveitis, we analyzed the expression of memory markers, CD29 and CD45RO antigens, and apoptosis-related Fas antigen on T lymphocytes in the aqueous humor (AH) and peripheral blood (PB) from patients with uveitis. Using three-color flow cytometry, we assessed...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689609007624
更新日期:1996-03-01 00:00:00
abstract::Four groups of BALB/c mice were treated locally with different concentrations (0.1-1.0%) of retinoic acid (Etretinate) ointment for a period of one to four weeks. A fifth group was treated with the ointment base only. Ia-positive dendritic cells were identified by an indirect immunofluorescence technique which was con...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689509033511
更新日期:1995-03-01 00:00:00
abstract:PURPOSE:To investigate the relationship between meibomian gland dysfunction (MGD) and incomplete blinking caused by cranial nerve seven (CN VII) palsy. METHODS:A prospective case series of 60 consecutive patients with unilateral CN VII palsy was evaluated for MGD. According to the House-Brackmann scale, patients were ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1007211
更新日期:2016-01-01 00:00:00
abstract::Purpose: To determine the prevalence of posterior segment manifestations among consecutive patients with pathological myopia attending our University Hospital general ophthalmology clinic and their association with age, refractive error, axial length and each other. Methods: Patients diagnosed with pathological myopia...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1606252
更新日期:2019-09-01 00:00:00
abstract::The immunochemical reactivities of the alpha A and alpha B subunits from bovine alpha-crystallin have been compared using 5 monoclonal antibodies and 2 polyvalent antisera. Each subunit bound the same maximum amount of antibody, regardless of its source, and each subunit was able to completely displace alpha-crystalli...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609020047
更新日期:1986-03-01 00:00:00
abstract::Calpains are calcium-activated proteinases which have been implicated in tissue differentiation and degeneration. The aims of the present study were: (1) to determine the relationship between postnatal age and calpain activity in the rat retina; (2) to test if calpain activity was aberrant in the RCS retina at differe...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508998502
更新日期:1995-08-01 00:00:00
abstract:PURPOSE:To assess the upper eyelid kinematics during spontaneous blinking in unilateral paralytic lagophthalmos before and after upper eyelid load with gold weight (GW) or autogenous temporalis fascia (TF) sling. DESIGN:Comparative case series. SUBJECTS:Patients with long-standing unresolved unilateral facial palsy w...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2015.1031252
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:The prospective study evaluated the effects of optical defocus on kinetic sensitivity using automated kinetic perimetry. MATERIALS AND METHODS:The 17 eyes of 17 healthy young participants were evaluated. All of the participants had myopia (≥ -5.00 D) and mild to no astigmatism (<1.00 D). Automated kinetic peri...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.961614
更新日期:2015-01-01 00:00:00
abstract::The lacrimal gland stores retinyl esters which are synthesized by the enzyme acyl CoA:retinyl acyl transferase. Retinol is released from retinyl ester reserves by retinyl ester hydrolase (REH). Since the lacrimal gland secretes retinol, this gland should also contain this enzyme. To identify bile salt-dependent REH ac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209033486
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:To determine retinal vessel diameter variations in response to neuronal activity induced by diffuse luminance flicker. METHODS:The diameter of retinal arteries and veins was measured in 9 normal subjects by computer analysis of fundus pictures taken in monochromatic light under normal conditions of illuminatio...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.12.1252.5021
更新日期:1997-12-01 00:00:00
abstract::To better define the growth requirements for corneal epithelial cells, methods for serum-free culture were established. Sheets of corneal epithelium from eyes of swine and rabbits were obtained by dispase treatment of corneal buttons, and single cells and small clumps were obtained by further dissociation with trypsin...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999564
更新日期:1990-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to characterize a standardized porcine ex-vivo testing system for intraocular pressure (IOP) monitoring after vitrectomy with different endotamponades. METHODS:Twenty-four pig eyes, six per endotamponade group were obtained immediately postmortem. After pars plana vitrectomy, vitreous...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1297461
更新日期:2017-08-01 00:00:00
abstract::The possible roles of monocytes and lymphocytes in vitreous fibrosis were examined by injecting various numbers of the peripheral cell types into the rabbit vitreous. Our results indicated that the degree of vitreous fibrosis and the presence of traction retinal detachment corresponded to the number of cells injected....
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809033223
更新日期:1988-12-01 00:00:00
abstract:PURPOSE:To review the microbiological spectrum and antibiotic sensitivities of the pathogens that cause culture-proven endophthalmitis and to understand the status and trends of antibiotic susceptibility at a public hospital over a 10-year period. METHODS:The data of 577 culture-proven endophthalmitis isolates collect...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1188118
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:In the mature retina retinoic acid (RA) biosynthesis was reported to be regulated by light. RA is of vital importance for proper function of the retina. RA activity is mediated by interaction with nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The purpose of this study was to determine ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.4.338.5307
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:To determine the plasma levels of the sulfur-containing amino-acids homocysteine, cysteine, cysteinylglycine, glutamylcysteine, glutathione, and taurine in patients with central retinal vein occlusion (CRVO) and in healthy subjects and to ascertain whether there are statistically significant differences between...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713681003698863
更新日期:2010-07-01 00:00:00
abstract::Purpose: To evaluate the efficacy of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing sustained-release thalidomide for delayed adjustable strabismus surgery. Methods: This is a prospective, masked-observer, controlled study using 50 eyes of 25 rabbits. After superior rectus muscle (SRM...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1591461
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To investigate the expression in the mouse retina and the function in a retinal cell of cullin5 that is known as a protein that is associated with ubiquitilation. METHODS:The retinal sites of expressing cullin5 were determined by immunohistochemistry with a specific antibody for cullin5. Retinal cells were tra...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.514658
更新日期:2011-01-01 00:00:00
abstract::Intraocular synthesis of IgG antibodies against HSV (herpes simplex virus), CMV (cytomegalovirus) and VZV (varicella zoster virus) is considered as an indirect proof of uveoretinal infection. Paired serum and aqueous samples obtained from 16 patients with retinitis associated with AIDS, 3 patients with ARN, 8 patients...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999412
更新日期:1990-01-01 00:00:00
abstract::The full length cDNA sequence for the lens-specific intermediate filament protein, CP49, from chicken is presented. The sequence contains features typical of the other intermediate filament proteins, including two major alpha-helical regions, helix I and II and appropriate linker regions. CP49 lacks a C-terminal non-a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508998401
更新日期:1995-07-01 00:00:00