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Angioinvasive fungal infections impacting the skin: Diagnosis, management, and complications.

Abstract：

:As discussed in the first article in this continuing medical education series, angioinvasive fungal infections pose a significant risk to immunocompromised and immunocompetent patients alike, with a potential for severe morbidity and high mortality. The first article in this series focused on the epidemiology and clinical presentation of these infections; this article discusses the diagnosis, management, and potential complications of these infections. The mainstay diagnostic tests (positive tissue culture with histologic confirmation) are often supplemented with serum biomarker assays and molecular testing (eg, quantitative polymerase chain reaction analysis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry) to ensure proper speciation. When an angioinvasive fungal infection is suspected or diagnosed, further workup for visceral involvement also is essential and may partially depend on the organism. Different fungal organisms have varied susceptibilities to antifungal agents, and knowledge on optimal treatment regimens is important to avoid the potential complications associated with undertreated or untreated fungal infections.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Berger AP,Ford BA,Brown-Joel Z,Shields BE,Rosenbach M,Wanat KA

doi

10.1016/j.jaad.2018.04.058

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

883-898.e2

issue

4

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(18)32370-3

journal_volume

80

pub_type

杂志文章,评审

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