Acanthosis nigricans: a cutaneous marker of tissue resistance to insulin.

abstract：:We reviewed all cases of malignant melanoma in children younger than 17 years of age who were evaluated at Sainte Justine Hospital, a tertiary care pediatric center, between 1980 and 2002. The medical records and histologic features of all cases were reviewed. Thirteen cases were identified, 4 boys and 9 girls. Fifty-...

journal_title：Journal of the American Academy of Dermatology

authors： Jafarian F,Powell J,Kokta V,Champagne M,Hatami A,McCuaig C,Marcoux D,Savard P

更新日期：2005-11-01 00:00:00

abstract：:The large stellate and polygonal cells observed in eleven fibrous papules and two angiofibromas were examined immunohistochemically for alpha 1-antitrypsin and lysozyme. The positive findings suggest that these cells are related to histiocytes rather than nevomelanocytes. ...

journal_title：Journal of the American Academy of Dermatology

authors： Kwan TH,Smoller BR,Schneider DR

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Pigmented Spitz nevi have distinct clinical features but often may be difficult to differentiate from malignant melanoma by clinical criteria. OBJECTIVE:The purpose of this study was to use a new noninvasive diagnostic approach to improve the clinical diagnosis of Spitz nevi. METHODS:Epiluminescence micros...

journal_title：Journal of the American Academy of Dermatology

authors： Steiner A,Pehamberger H,Binder M,Wolff K

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Dermatomyositis (DM) is a multisystem autoimmune disease, in which serologic evidence of immune responses to disease-specific antigenic targets is found in approximately 50% to 70% of patients. Recently, melanoma differentiation-associated gene 5 (MDA5) has been identified as a DM-specific autoantigen that a...

journal_title：Journal of the American Academy of Dermatology

authors： Fiorentino D,Chung L,Zwerner J,Rosen A,Casciola-Rosen L

更新日期：2011-07-01 00:00:00

abstract：:The Patient Protection and Affordable Care Act will have substantial effects on the US health care system. Physicians hold varied opinions regarding the overall merits or drawbacks of the health system reform law, but it is critical that we understand its components and the implications for our practices and our patie...

journal_title：Journal of the American Academy of Dermatology

authors： Resneck JS Jr

更新日期：2010-10-01 00:00:00

abstract：:Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population. With the appropriate knowledge of the imp...

journal_title：Journal of the American Academy of Dermatology

authors： Olsen EA

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Treatment guidelines are lacking for classic Kaposi sarcoma. OBJECTIVE:We sought to review the evidence on efficacy of treatments for classic Kaposi sarcoma. METHODS:Articles published in English or French in MEDLINE, Trip, Cochrane Library, and Pascal databases from 1980 to December 2010 were screened. St...

journal_title：Journal of the American Academy of Dermatology

authors： Régnier-Rosencher E,Guillot B,Dupin N

更新日期：2013-02-01 00:00:00

abstract：:We report reactive perforating collagenosis in an intravenous heroin abuser with acquired immunodeficiency syndrome and end-stage renal disease. The literature on perforating disorders in patients with acquired immunodeficiency syndrome and the pathogenesis of reactive perforating collagenosis in this setting is revie...

journal_title：Journal of the American Academy of Dermatology

authors： Bank DE,Cohen PR,Kohn SR

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:The histopathological and clinical overlapping features between condyloma acuminata and bowenoid papulosis can present a diagnostic challenge and we sought to determine if immunochemistry can be helpful in this setting. OBJECTIVE:In this study, we evaluate the specificity and sensitivity of p16 immunohistoc...

journal_title：Journal of the American Academy of Dermatology

authors： Kazlouskaya V,Shustef E,Allam SH,Lal K,Elston D

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The mature psoriatic lesion does not necessarily demonstrate changes relevant to early phases of the lesion. OBJECTIVE:In a model for relapsing psoriasis we examined the epidermal phenotype by means of a panel of immunohistochemical parameters: keratins 14 and 16, epidermal growth factor receptor (EGFR), Ki...

journal_title：Journal of the American Academy of Dermatology

authors： Castelijns FA,Gerritsen MJ,van Vlijmen-Willems IM,van Erp PE,van de Kerkhof PC

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Detection of melanoma by physicians via opportunistic surveillance during focused physical examinations may reduce mortality. Medical students may not encounter a clinical case of melanoma during a dermatology clerkship. OBJECTIVE:This study examined the proficiency of fourth-year University of Illinois at ...

journal_title：Journal of the American Academy of Dermatology

authors： Hernandez C,Mermelstein R,Robinson JK,Yudkowsky R

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The pathologic evaluation of mycosis fungoides (MF) is a challenging area in dermatopathology. OBJECTIVE:We sought to determine the usefulness of flow cytometry for the diagnosis of MF from skin biopsy specimens. METHODS:Skin biopsy specimens from 22 patients with a clinical suggestion for MF were evaluate...

journal_title：Journal of the American Academy of Dermatology

authors： Oshtory S,Apisarnthanarax N,Gilliam AC,Cooper KD,Meyerson HJ

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud is an uncommon disorder of unknown cause for which a variety of treatments have been proposed. OBJECTIVE:We attempted to evaluate the effectiveness of oral minocycline. METHODS:Nine patients with CRP were treated with oral minocycline,...

journal_title：Journal of the American Academy of Dermatology

authors： Montemarano AD,Hengge M,Sau P,Welch M

更新日期：1996-02-01 00:00:00

abstract：:Scleromyxedema is a rare fibromucinous connective tissue that can be associated with systemic changes, such as myopathy, neurologic defects, esophageal dysmotility, paraproteinemia, and restrictive lung disease. We describe a fatal case of scleromyxedema in which neurologic, cardiac, gastrointestinal, and muscle chang...

journal_title：Journal of the American Academy of Dermatology

authors： Godby A,Bergstresser PR,Chaker B,Pandya AG

更新日期：1998-02-01 00:00:00

abstract：:Hutchinson's sign, periungual extension of brown-black pigmentation from longitudinal melanonychia onto the proximal and lateral nailfolds, is an important indicator of subungual melanoma. However, experience has demonstrated that Hutchinson's sign, although valuable, is not an infallible predictor of melanoma. Periun...

journal_title：Journal of the American Academy of Dermatology

authors： Baran R,Kechijian P

更新日期：1996-01-01 00:00:00

abstract：:Renewed interest in experimental photocarcinogenesis was stimulated by the observation that skin cancers induced in mice by ultraviolet radiation are highly antigenic. Most of these cancers are rejected by the immune system on transplantation into a normal, genetically identical animal. This finding raised the questio...

journal_title：Journal of the American Academy of Dermatology

authors： Kripke ML

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Hereditary polymorphic light eruption (HPLE) occurs unique ly in the American Indian and Inuit and exhibits autosomal dominant transmission. Because the cutaneous expression of HPLE resembles that of polymorphic light eruption (PLE) and because many non-Indians in the United States have American Indian herit...

journal_title：Journal of the American Academy of Dermatology

authors： Fusaro RM,Johnson JA

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Drug-specific T cells are involved in the pathogenesis of cutaneous adverse drug reactions (CADRs). OBJECTIVE:We sought to evaluate the diagnostic role of in vitro drug-induced release of interferon gamma in CADRs. METHODS:The study group consisted of 36 patients with CADRs after intake of 106 drugs that w...

journal_title：Journal of the American Academy of Dermatology

authors： Halevy S,Cohen AD,Grossman N

更新日期：2005-02-01 00:00:00

abstract：:We describe the clinical and biochemical features of an infant with marked transient porphyrinemia in whom blistering developed while the infant was undergoing phototherapy for severe Rh isoimmunization. The cause of the transient porphyrinemia was likely to be multifactorial--abnormal porphyrin metabolism or accumula...

journal_title：Journal of the American Academy of Dermatology

authors： Mallon E,Wojnarowska F,Hope P,Elder G

更新日期：1995-08-01 00:00:00

abstract：:Isolated plantar cerebriform collagenomas are a relatively rare type of connective tissue nevus. They have been suggested to be pathognomonic of Proteus syndrome. However, their presence is now considered to be a major criterion of Proteus syndrome, but the diagnosis of Proteus syndrome also requires the presence of o...

journal_title：Journal of the American Academy of Dermatology

authors： Nelson AA,Ruben BS

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Lipedematous alopecia and lipedematous scalp are two similar unusual conditions mostly affecting healthy black women. OBJECTIVE:The purpose of our study was to report three cases of this condition with emphasis on clinical and histologic findings, and to review the literature on the subject. METHODS:The st...

journal_title：Journal of the American Academy of Dermatology

authors： Martín JM,Monteagudo C,Montesinos E,Guijarro J,Llombart B,Jordá E

更新日期：2005-01-01 00:00:00

abstract：:Infections with mycobacteria are of importance in the differential diagnosis of skin lesions in immunocompromised patients. We report the case of a human immunodeficency virus (HIV)-infected patient who presented with an annular plaque as cutaneous manifestation of Mycobacterium haemophilum. Improvement of the immunol...

journal_title：Journal of the American Academy of Dermatology

authors： Friedli A,Krischer J,Hirschel B,Saurat JH,Pechère M

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:The possible association of silicone breast implants and disease is a subject of continuous debate and concern. OBJECTIVE:Our purpose was to examine microscopically and ultrastructurally the periprosthetic fibrous capsules and reconstruction scars of women with silicone breast implants. METHODS:Representat...

journal_title：Journal of the American Academy of Dermatology

authors： Raso DS,Greene WB,Harley RA,Maize JC

更新日期：1996-07-01 00:00:00

abstract：:From the origin of civilization the pursuit of beauty has exemplified the highest order of the human being's quest for achievement, and from the beginning, this pursuit has focused, in part, on perfecting the human form. Freed from much of the time-consuming burden of attending to elemental needs, the present generati...

journal_title：Journal of the American Academy of Dermatology

authors： Basler RS

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Condyloma acuminatum are common lesions caused by human papillomavirus (HPV). HPV is associated with many human cancers, and a vaccine now prevents infection with high-risk HPV. However, eradication of established disease is difficult, indicating that these lesions are capable of local immunosuppression. OB...

journal_title：Journal of the American Academy of Dermatology

authors： Le Poole C,Denman CJ,Arbiser JL

更新日期：2008-12-01 00:00:00

abstract：:Cicatricial pemphigoid is a chronic, presumed autoimmune, blistering disease of the mucous membranes and occasionally of the skin. The characteristic feature is scarring at the sites of healing. We report the use of thalidomide as a therapeutic agent to control previously resistant disease. ...

journal_title：Journal of the American Academy of Dermatology

authors： Duong DJ,Moxley RT 3rd,Kellman RM,Pincus SH,Gaspari AA

更新日期：2002-08-01 00:00:00

abstract：:We report 2 cases of relapsing nummular dermatitis according to mercury sensitivity, which was confirmed by patch testing. Removal of the amalgam from dental metal alloys markedly improved their skin eruptions. One of the patients, a dentist, experienced exacerbation of the eruptions on his lower legs after handling d...

journal_title：Journal of the American Academy of Dermatology

authors： Adachi A,Horikawa T,Takashima T,Ichihashi M

更新日期：2000-08-01 00:00:00

abstract：:Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance thera...

journal_title：Journal of the American Academy of Dermatology

authors： Join-Lambert O,Duchatelet S,Delage M,Miskinyte S,Coignard H,Lemarchand N,Alemy-Carreau M,Lortholary O,Nassif X,Hovnanian A,Nassif A

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Tinea corporis gladiatorum has been an infrequently reported condition in the dermatological literature. Two previous reports have investigated wrestlers during recognized epidemics of tinea corporis gladiatorum, but no study has examined wrestlers to determine the point prevalence of tinea corporis gladiato...

journal_title：Journal of the American Academy of Dermatology

authors： Adams BB

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Dermoscopy improves the recognition of melanoma and Spitz nevus but occasionally melanoma may exhibit a symmetric pattern mimicking Spitz nevus. OBJECTIVE:We sought to investigate the likelihood of finding melanoma when excising a symmetric Spitzoid-looking lesion in patients aged 12 years or older. METHOD...

journal_title：Journal of the American Academy of Dermatology

authors： Lallas A,Moscarella E,Longo C,Kyrgidis A,de Mestier Y,Vale G,Guida S,Pellacani G,Argenziano G

更新日期：2015-01-01 00:00:00