Abstract：
OBJECTIVES:A number of studies conducted to assess the association between Clara cell 10-kDa protein (CC10) +38A/G polymorphism and susceptibility to asthma have yielded inconsistent and inconclusive results. In the present study, the possible association was assessed by a meta-analysis. METHODS:Relevant articles were identified for the period ranging from Jan 1998 up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed effects or random-effects models. RESULTS:Ten case-control studies with a total of 1529 asthma cases and 2399 controls were included in this meta-analysis. The association between CC10 +38A/G polymorphism and asthma risk was determined in dominant model, recessive model, additive model, and codominant model. In dominant model, CC10 +38A/G polymorphism seemed to be associated with elevated asthma risk (OR = 1.62; 95% CI, 1.23-2.12; P = 0.0005). Subgroup analyses by ethnicity also found significant associations between this polymorphism and asthma risk in Asians and Caucasians. RESULTS from other genetic models further identified this possible association. CONCLUSION:This meta-analysis suggests that CC10 +38A/G polymorphism confers asthma risk.
journal_name
Pak J Med Scijournal_title
Pakistan journal of medical sciencesauthors
Zhao G,Lin X,Zhou M,Zhao Jdoi
10.12669/pjms.296.3724subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1439-43issue
6eissn
1682-024Xissn
1681-715Xjournal_volume
29pub_type
杂志文章,评审abstract：OBJECTIVE:To compare the neuro-radiologic findings in Systemic lupus erythematosus (SLE) patients with and without antiphospholipid antibodies (aPL) in different neuro-psychiatric manifestations. METHODS:This cross-sectional comparative study was carried out at King Khalid University Hospital, a tertiary care teaching...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.315.7975
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVES:Ventilator-associated pneumonia (VAP) is a significant cause of hospital-related infections, one that must be prevented due to its high morbidity and mortality. The purpose of this study was to evaluate the incidence and risk factors in patients developing VAP in our intensive care units (ICUs). METHODS:Thi...
journal_title：Pakistan journal of medical sciences
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doi：10.12669/pjms.324.10381
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVES:To determine the prevalence of dental caries, and associated social risk factors among preschool children in Riyadh, Saudi Arabia. METHODS:The study consisted of a random sample of 3 to 5 years- old preschool children who were examined in Riyadh, Saudi Arabia; 388 children (184 boys and 204 girls) were exam...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.322.9439
更新日期：2016-03-01 00:00:00
abstract：Objectives:Epilepsy is one of the most common chronic neurologic disorders in childhood and it affects 0.5-1% of children. The purpose of the study was to determine the prevalence and types of structural abnormalities in the epileptic children. Methods:The study was performed in Near East University and Dr. Suat Gunse...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.342.14807
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the prevalence and the individual components of metabolic syndrome (MetS) in Jordanian adults. METHODS:In this cross sectional study, 630 adult subjects (308 men and 322 women) aged between 20-70 years were recruited from the clinics at the King Hussein Medical Center. The diagnosis of MetS was m...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.316.7714
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To study the effect and clinical value of mammography in the diagnosis of breast lump so as to improve the diagnosis level of breast cancer. METHODS:A retrospective analysis was carried out on clinical data of 110 patients with mammary lump confirmed by pathology to study the compliance of mammography diagno...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.324.9384
更新日期：2016-07-01 00:00:00
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pub_type： 杂志文章
doi：10.12669/pjms.344.14391
更新日期：2018-07-01 00:00:00
abstract：Objective:To determine the efficacy of oral eplerenone in anatomical and functional improvement in patients with chronic central serous chorioretinopathy (CSCR). Methods:This quasi experimental study was performed at PNS Shifa Hospital Karachi from September 2018 to February 2019. Study included 23 patients. Patients ...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.35.6.896
更新日期：2019-11-01 00:00:00
abstract：Objective:To compare the effects of simple saline dressings versus topical vancomycin dressings on Methicillin-resistant Staphylococcus Aureus positive chronic diabetic foot ulcers. Methods:It was quasi experimental study conducted in Combined Military Hospital Kohat and PNS-Shifa Hospital Karachi from 01 January 2017...
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pub_type： 杂志文章
doi：10.12669/pjms.35.4.368
更新日期：2019-07-01 00:00:00
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journal_title：Pakistan journal of medical sciences
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更新日期：2014-03-01 00:00:00
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journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.291.2896
更新日期：2013-01-01 00:00:00
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journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.331.11758
更新日期：2017-01-01 00:00:00
abstract：Objective:To investigate the predictive validity of Uniform Entrance Test for academic performance in the first two years in various health science degree programs. Methods:A retrospective analysis of admissions data and academic performance of students admitted in under-graduate programs of medicine, dentistry and ph...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.35.2.334
更新日期：2019-03-01 00:00:00
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journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.333.12294
更新日期：2017-05-01 00:00:00
abstract：Objective:Zinc is a vital trace element and its deficiency in cirrhosis might potentiate the development of hepatic encephalopathy. The objective of this study was to assess the zinc levels in serum of patients having viral cirrhosis and compare it with normal healthy controls. Methods:This study was conducted in Depa...
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pub_type： 杂志文章
doi：10.12669/pjms.342.14457
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:Trendelenburg positioning is a common approach used during internal jugular vein (IJV) cannulation. No evidence indicates that Trendelenburg positioning significantly increases the cross-sectional area (CSA) of the IJV in obese patients. The primary aim of this study was to determine the effectiveness of Tren...
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pub_type： 杂志文章
doi：10.12669/pjms.314.7326
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:To determine an association between body composition analysis and physical fitness in the Saudi population and derive gender specific physical fitness equations. METHODS:A total of 530 healthy Saudi adults aged 15-72 years (mean 37.16±14.12 years) were enrolled in this study. Body composition analysis was as...
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pub_type： 杂志文章
doi：10.12669/pjms.304.4974
更新日期：2014-07-01 00:00:00
abstract：Objectives:To assess the immediate effect of TEAM® on trauma related knowledge of undergraduate medical students and to highlight the stakeholders' acceptability of TEAM® for trauma training of undergraduate medical students. Methods:Effectiveness of TEAM® course in terms of knowledge gain was assessed using 20-item-M...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.36.6.2588
更新日期：2020-09-01 00:00:00
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journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.36.6.1982
更新日期：2020-09-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
abstract：Objective:To investigate the relationship between myocardial enzymes, liver function and metabolic acidosis in children with rotavirus infection diarrhea. Methods:The data of 70 children with infectious diarrhea treated in Baoding Children's Hospital, China, from October 2017 to April 2018 were retrospectively studied...
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pub_type： 杂志文章
doi：10.12669/pjms.36.6.2325
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:To compare the effects of thoracotomy and total thoracoscopic surgery on coronary artery fistulae complicated with ectasia. METHODS:Forty-six patients with coronary artery fistulae complicated with ectasia were randomly divided into a treatment group and a control group (n=23) which were given totally thorac...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.321.7501
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To share our findings that the new treatment modality Video Assisted Anal Fistula Treatment (VAAFT) is a better alternate to the conventional treatments of Fistula in Ano in our setup with minor changes in the initial method described by Meinero. METHODS:Karl Storz Video equipment including Meinero Fistulosc...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.315.6836
更新日期：2015-09-01 00:00:00
abstract：Objective:To evaluate the diagnostic accuracy of ultrasound in obstructive jaundice taking MRCP as gold standard. Methods:This cross-sectional study was conducted at Dow Institute of Radiology (DIR), Dow University of Health Sciences (DUHS), Karachi from 2nd May 2018 till 2nd November 2018. Both male and female patien...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.36.4.1665
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Each year millions of Muslims perform pilgrimage to Makkah, Saudi Arabia. It is particularly stressful during the peak five days, when all rituals have to be performed at specific periods of time at different sites. Poor diabetes control in people with diabetes predisposes to morbidity and incr...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.325.11217
更新日期：2016-09-01 00:00:00
abstract：Objective:To study the clinical, biochemical and radiological features and management outcomes of patients with primary hyperparathyroidism. Methods:This retrospective study was conducted at the Aga Khan University Hospital, Karachi, Pakistan and comprised data of patients with primary hyperparathyroidism from 2008 to...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.36.6.2572
更新日期：2020-09-01 00:00:00
abstract：Objective:To determine diagnostic accuracy of NMP 22 and urine cytology in the detection of transitional cell carcinoma (TCC) urinary bladder taking cystoscopy as a gold standard in patients having provisional diagnosis of bladder cancer (BC). Methods:This cross sectional validational study enrolled 380 patients fulfi...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.36.4.1638
更新日期：2020-05-01 00:00:00
abstract：Objective:Work-related asthma (WRA) is one of the most common occupational diseases. In this study, we aimed to review diagnosing procedures and the characteristics of patients who were diagnosed with WRA. Methods:Between November 2013 and June 2016; 214 patients were referred to our clinic with WRA suspicion by an oc...
journal_title：Pakistan journal of medical sciences
pub_type： 杂志文章
doi：10.12669/pjms.335.12923
更新日期：2017-09-01 00:00:00
