Effect of oral eplerenone in anatomical and functional improvement in patients with chronic central serous chorioretinopathy.

Abstract:

Objective:To determine the efficacy of oral eplerenone in anatomical and functional improvement in patients with chronic central serous chorioretinopathy (CSCR). Methods:This quasi experimental study was performed at PNS Shifa Hospital Karachi from September 2018 to February 2019. Study included 23 patients. Patients were included using consecutive sampling technique and informed consent was taken from all patients before staring treatment. 50 mg of oral eplerenone per day was given for three months. Subretinal fluid (SRF) height and visual acuity (VA) were noted at baseline, one month and three month follow-up. Structured Study performa was used for data collection. Data was analysed and assessed with SPSS version 23. P value of <0.05 was considered statistically significant. Results:Mean age of patients was 40.7±7 years and mean duration of disease before treatment was 3.7±0.76 months. Mean baseline BCVA and SRF height was 0.39±0.02 logMAR and 123±12.5 µm respectively. Sixty-five percent patients responded at one month and 80% at three months with reduction in SRF height. Improvement in visual acuity was also statistically significant at 3 months (p<0.05). Conclusion:Use of eplerenone in chronic CSCR resulted in significant improvement in vision and decrease in mean SRF height.

journal_name

Pak J Med Sci

authors

Farooq O,Habib A,Shah MA,Ahmed N

doi

10.12669/pjms.35.6.896

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1544-1547

issue

6

eissn

1682-024X

issn

1681-715X

pii

PJMS-35-1544

journal_volume

35

pub_type

杂志文章
  • An assessment of knowledge, attitude and practices (KAP) towards diabetes and diabetic retinopathy in a suburban town of Karachi.

    abstract:OBJECTIVE:To assess the Knowledge, Attitude and Practices (KAP) towards diabetes and diabetic retinopathy in the general population of Bin Qasim Town (BQ), Karachi. METHODS:An observational, cross-sectional study was approved by Research Ethical Committee of Al-Ibrahim Eye Hospital. It included every third household b...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.311.6317

    authors: Memon MS,Shaikh SA,Shaikh AR,Fahim MF,N Mumtaz S,Ahmed N

    更新日期:2015-01-01 00:00:00

  • Insulin resistance in non-diabetic patients of chronic Hepatitis C.

    abstract:OBJECTIVE:To determine insulin resistance in non-diabetic chronic hepatitis C patients using Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). METHODOLOGY:Patients having anti-HCV positive were included in this study. Patients with diabetes mellitus, thyroid disease, hyperlipidemias, hypercortisolism and i...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.291.2888

    authors: Kiran Z,Zuberi BF,Anis D,Qadeer R,Hassan K,Afsar S

    更新日期:2013-01-01 00:00:00

  • Anatomical predicting factors of difficult spinal anesthesia in patients undergoing cesarean section: An observational study.

    abstract:Objectives:Although Spinal anesthesia is the most common and safe anesthetic method for patients undergoing cesarean section, difficult access to it is a frequent problem in operating theaters. The predictive factors for the difficulty of spinal anesthesia in patients undergoing cesarean section were investigated. Met...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.6.1276

    authors: Atashkhoei S,Samudi S,Abedini N,Khoshmaram N,Minayi M

    更新日期:2019-11-01 00:00:00

  • Clinical exploration of marking targeting biopsy in the intraoperative localization value of colon polypectomy.

    abstract:Objective:To evaluate the feasibility and safety of marking targeting biopsy (MTB) in the intraoperative localization value of colon polypectomy. Methods:The clinical data from patients with polyp of colon discovered under colonoscopy from January 2014 to January 2016 were retrospectively analyzed. A total of 87 patie...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.2.756

    authors: Song LY,Lin Q,Li LB,Cheng X

    更新日期:2020-01-01 00:00:00

  • Role of Vitamin D in reducing number of acute exacerbations in Chronic Obstructive Pulmonary Disease (COPD) patients.

    abstract:BACKGROUND AND OBJECTIVE:Chronic obstructive pulmonary disease (COPD) is characterized by chronic incompletely reversible poor airflow and air trapping and usually this debilitating disorder limits the outside activities of the patients depriving them of sunlight which is a rich source of Vitamin D. The objective of th...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.333.12397

    authors: Khan DM,Ullah A,Randhawa FA,Iqtadar S,Butt NF,Waheed K

    更新日期:2017-05-01 00:00:00

  • Effects of topical Vancomycin Dressing on Methicillin-Resistant Staphylococcus Aureus (MRSA) positive diabetic foot ulcers.

    abstract:Objective:To compare the effects of simple saline dressings versus topical vancomycin dressings on Methicillin-resistant Staphylococcus Aureus positive chronic diabetic foot ulcers. Methods:It was quasi experimental study conducted in Combined Military Hospital Kohat and PNS-Shifa Hospital Karachi from 01 January 2017...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.4.368

    authors: Saif AB,Jabbar S,Akhtar MS,Mushtaq A,Tariq M

    更新日期:2019-07-01 00:00:00

  • Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer.

    abstract:Objective:To evaluate the clinical efficacy of intensity modulated radiation therapy and endocrinotherapy for middle and advanced prostate cancer. Methods:Total 104 elderly patients with middle and advanced prostate cancer who were admitted to our hospital from November 2014 to August 2015 were selected using random n...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.5.591

    authors: Zhang S,Zhao S,Fu X

    更新日期:2019-09-01 00:00:00

  • Ultrasound diagnosis of age-related involutional changes in the lower third of face and neck to determine treatment techniques.

    abstract:Objective:To develop a clinical technique for objective estimation of exact location and degree of participation of face and neck soft tissues in age-related deformations for determine effective mini-invasive treatment techniques. Methods:Ultrasound examination was performed in 2017-2019 at 63 patients with age-relate...

    journal_title:Pakistan journal of medical sciences

    pub_type:

    doi:10.12669/pjms.37.1.3034

    authors: Sharobaro V,Alimova S,Telnova A,Shamanaeva L

    更新日期:2021-01-01 00:00:00

  • Psychological well-being of substance use patient: Role of religious therapy as the treatment.

    abstract:Objective:To evaluate the psychological well-being of substance use patients in comparison of combined religious therapy and pharmacotherapy effects with that of pharmacotherapy effects alone and also to assess the psychological well-being of drug addicts in comparison of demographics characteristics. Methods:This exp...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.5.561

    authors: Bano Z,Naz I,Leghari N,Ahmed I

    更新日期:2019-09-01 00:00:00

  • The learning environment of four undergraduate health professional schools: Lessons learned.

    abstract:Background and Objectives:Learning is an interplay between cognition and environmental factors. Any learning environment, that fulfills the intrinsic and extrinsic needs of the students will probably lead to better and more promising learning outcomes. This study aimed to investigate the student perceptions of Learning...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.3.712

    authors: Irfan F,Faris EA,Maflehi NA,Karim SI,Ponnamperuma G,Saad H,Ahmed AM

    更新日期:2019-01-01 00:00:00

  • Culture and PCR based detection of bacteria causing urinary tract infection in urine specimen.

    abstract:Objectives:Urinary tract infections are the second most common bacterial infections occurring at all ages and both sexes. The increasing rate of antibiotic resistance is a global concern. The use of routinely used antibiotics is resulting in treatment failure. The objective of this study was to diagnose the urinary tra...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.3.1577

    authors: Pirkani GS,Awan MA,Abbas F,Din M

    更新日期:2020-03-01 00:00:00

  • Perceived social support in pregnant adolescents in Mersin area in Turkey.

    abstract:Objective:The study examines the level and source of perceived social support in pregnant adolescents and the factors related to their perception of social support. Methods:This descriptive study was conducted with the voluntary participation of 127 adolescent pregnant females who visited the Gynecology and Pediatric ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.341.14221

    authors: Yurdakul M

    更新日期:2018-01-01 00:00:00

  • A comparison of the scorings of real and standardized patients on physician communication skills.

    abstract:OBJECTIVES:To compare the scorings of real and standardized patients on physician communication skills. METHODS:Patient scoring (n=183) on physicians' communication skills was determined by 93 real and 90 standardized patients. Eighty physicians (42 specialists and 38 general physicians) in private practice were enrol...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.303.3255

    authors: Rezaei R,Mehrabani G

    更新日期:2014-05-01 00:00:00

  • Effect of gastric residual volume monitoring on incidence of ventilator-associated pneumonia in mechanically ventilated patients admitted to intensive care unit.

    abstract:Objectives:The value of gastric residual volume (GRV) monitoring in ventilator-associated pneumonia (VAP) has frequently been questioned in the past years. In this trial, the effect of GRV on the frequency of VAP was evaluated in critically ill patients under mechanical ventilation. Methods:This descriptive study was ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.2.1321

    authors: Faramarzi E,Mahmoodpoor A,Hamishehkar H,Shadvar K,Iranpour A,Sabzevari T,Sanaie S

    更新日期:2020-01-01 00:00:00

  • Impact of an IEC (Information, Education and Communication) intervention on key family practices of mothers related to child health in Jamshoro, Sindh.

    abstract:OBJECTIVE:To determine change in practice of mothers having children less than five years of age in five key areas related to child health, growth and development including immunization, feeding during illness, appropriate home treatment for infections and care seeking behavior. METHODS:This was a community based inte...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.303.4798

    authors: Shaikh S,Memon S,Ahmed I,Amna,Manzoor R,Shaikh S

    更新日期:2014-05-01 00:00:00

  • Allergic Fungal rhino-sinusitis frequency in chronic rhino-sinusitis patients and accuracy of fungal culture in its diagnosis.

    abstract:Objective:To determine the frequency of Allergic Fungal Rhino-sinusitis (AFRS) in Chronic Rhino-sinusitis (CRS) patients and the accuracy of fungal culture in diagnosing AFRS. Methods:Immunocompetent patients with CRS and without invasive fungal rhino-sinusitis presenting over a period of 3 years in ENT department of ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.3.1661

    authors: Awan NU,Cheema KM,Naumeri F,Qamar S

    更新日期:2020-03-01 00:00:00

  • The relationship between dispositional empathy and prefrontal cortical functioning in patients with frontal lobe epilepsy.

    abstract:BACKGROUND & OBJECTIVE:Rehabilitation focuses brain-behavior relationship which highlights interaction between psychological and neurobiological factors for better patient care. There is a missing link in the literature about socio-cognitive aspects of frontal lobe epilepsy. Our objective was to examine prefrontal cort...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.331.11742

    authors: Gul A,Ahmad H

    更新日期:2017-01-01 00:00:00

  • KCNQ1 rs2237895 polymorphism is associated with Gestational Diabetes in Pakistani Women.

    abstract:BACKGROUND AND OBJECTIVE:Genetic studies on gestational diabetes (GDM) are relatively scarce; moreover, limited data is available for KCNQ1 polymorphism in Pakistani pregnant women. We aimed to determine the frequency of KCNQ1 rs2237895 in GDM and normal pregnant controls and its association with GDM-related phenotypes...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.326.11052

    authors: Fatima SS,Chaudhry B,Khan TA,Farooq S

    更新日期:2016-11-01 00:00:00

  • Effect of energy drink consumption on baroreceptor sensitivity in young normal weight and overweight/obese males.

    abstract:Objectives:There is lack of evidence exploring sympathetic effect by baroreceptor sensitivity in obese consuming energy drink. The purpose of this study was to investigate the acute effect of energy drink on individuals baroreceptor sensitivity in young healthy normal weight and overweight/obese males. Methods:This cr...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.7.2419

    authors: Majeed F,Yar T,Alsunni AA,AlHawaj AF,AlRahim AA

    更新日期:2020-11-01 00:00:00

  • Mixed method survey to assess the problems and propose solutions for implementation of CME/CPD in Sindh, Pakistan.

    abstract:Objectives:To determine the type of CME/CPD sessions attended by doctors, identify the problems with implementation of CME/CPD program and propose possible solutions for successful implementation of CME/CPD Program. Methods:This was a concurrent triangulation mixed method study. Quantitative questionnaires were filled...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.2.243

    authors: Shah N,Soomro M,Musharraf M,Shaikh S

    更新日期:2019-03-01 00:00:00

  • Fetomaternal outcome of pregnancy with Mitral stenosis.

    abstract:OBJECTIVE:To evaluate the frequency of fetomaternal outcome of pregnancy with Mitral stenosis admitted in Civil Hospital Karachi. METHODS:It was a two years descriptive study done in the Department of Obstetrics and Gynaecology Civil Hospital Karachi. All pregnant women with a known or newly diagnosed Mitral stenosis ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.313.7020

    authors: Ahmed N,Kausar H,Ali L,Rakhshinda

    更新日期:2015-01-01 00:00:00

  • Clinical Characteristics and Immediate-Outcome of Children Mechanically Ventilated in PICU of Pakistan.

    abstract:UNLABELLED:Back ground and Objective: Mechanical Ventilation (MV) is frequently used as one of the most frequent life-supportive technology in Pediatric Intensive Care Units (PICUs). Very little data is available from Asian countries like Pakistan regarding use of MV in PICUs. Our objective was to assess the frequency,...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.305.5159

    authors: Mukhtar B,Siddiqui NR,Haque A

    更新日期:2014-09-01 00:00:00

  • The results of photorefractive keratectomy with Mitomycin-C in myopia correction after 5 years.

    abstract:OBJECTIVE:To evaluate the results of photorefractive keratectomy (PRK) with mitomycin C in myopia correction after five years. METHODS:This is a cross sectional study which included 145 eyes of 74 patients in 18 to 51 years age group that were undergoing Photorefractive keratectomy with mitomycin C using Allegretto Wa...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.321.8576

    authors: Hashemi M,Amiri MA,Tabatabaee M,Ayatollahi A

    更新日期:2016-01-01 00:00:00

  • Clinical value of mammography in diagnosis and identification of breast mass.

    abstract:OBJECTIVE:To study the effect and clinical value of mammography in the diagnosis of breast lump so as to improve the diagnosis level of breast cancer. METHODS:A retrospective analysis was carried out on clinical data of 110 patients with mammary lump confirmed by pathology to study the compliance of mammography diagno...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.324.9384

    authors: Li H,Zhang S,Wang Q,Zhu R

    更新日期:2016-07-01 00:00:00

  • Reperfusion times of ST-Segment elevation myocardial infarction in hospitals.

    abstract:OBJECTIVE:To investigate the reperfusion time in patients with ST-segment elevation myocardial infarction (STEMI) in Henan Province, China, and discuss the strategies for shortening that period. METHODS:The reperfusion times of 1556 STEMI cases in 30 hospitals in Henan Province were analyzed from January 2008 to Augus...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.306.5696

    authors: Dong S,Chu Y,Zhang H,Wang Y,Yang X,Yang L,Chen L,Yu H

    更新日期:2014-11-01 00:00:00

  • Correlation of hematological indices and ratios derived from them with FIQR scores in fibromyalgia.

    abstract:Objectives:To determine the hematological indices and ratios derived from them in patients with fibromyalgia and to correlate the scores of Fibromyalgia Impact Questionnaire Revised (FIQR) with the ratios. Methods:This case control study was performed in the College of Pharmacy at Hawler Medical University in Erbil-Ir...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.345.15169

    authors: Al-Nimer MSM,Mohammad TAM

    更新日期:2018-09-01 00:00:00

  • What gastroenterologists should know during COVID-19 Pandemic!

    abstract::The WHO has declared a Pandemic due to Novel Corona virus-19 (COVID-19). Patients usually have respiratory symptoms but gastrointestinal and hepatic dysfunction are not uncommon presentations and can lead to a delay in diagnosis and management. Virus shedding can continue even after the nasopharyngeal swab gets negati...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.COVID19-S4.2651

    authors: Kamani L

    更新日期:2020-05-01 00:00:00

  • Prevalence of extensive drug resistance in bacterial isolates harboring blaNDM-1 in Quetta Pakistan.

    abstract:Objective:Extensive drug resistant Gram-negative bacilli, harboring New Delhi metallo-β-lactamase-1 (blaNDM-1) having the ability to hydrolyze β-lactams, have become a vital global clinical threat. The present study was, therefore, designed to investigate the prevalence and epidemiology of NDM-1 producers in Quetta, Pa...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.4.372

    authors: Din M,Babar KM,Ahmed S,Aleem A,Shah D,Ghilzai D,Ahmed N

    更新日期:2019-07-01 00:00:00

  • An assessment of ventilator-associated pneumonias and risk factors identified in the Intensive Care Unit.

    abstract:OBJECTIVES:Ventilator-associated pneumonia (VAP) is a significant cause of hospital-related infections, one that must be prevented due to its high morbidity and mortality. The purpose of this study was to evaluate the incidence and risk factors in patients developing VAP in our intensive care units (ICUs). METHODS:Thi...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.324.10381

    authors: Karatas M,Saylan S,Kostakoglu U,Yilmaz G

    更新日期:2016-07-01 00:00:00

  • Beyond transmission: Dire need for integration of nutrition interventions in COVID-19 pandemic-response strategies in Developing Countries like Pakistan.

    abstract::Synergistic associations between infection and nutrition are well known. Impact of nutrition interventions on the outcomes have been scientifically assessed and reported. The role of nutrition in limiting the infection related morbidity and mortality does not appear to be a debatable question but nutrition interventio...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章,评审

    doi:10.12669/pjms.36.COVID19-S4.2784

    authors: Hakeem R,Sheikh MA

    更新日期:2020-05-01 00:00:00