Primary Hyperparathyroidism: Experience from a Tertiary Care Centre in Pakistan.

Abstract:

Objective:To study the clinical, biochemical and radiological features and management outcomes of patients with primary hyperparathyroidism. Methods:This retrospective study was conducted at the Aga Khan University Hospital, Karachi, Pakistan and comprised data of patients with primary hyperparathyroidism from 2008 to 2017. Results:Out of 103 patients, 83(80.6%) were female. Overall mean age was 59.3±16.2 years. Musculoskeletal manifestations were seen in 60(58.3%) patients and renal manifestations in 28(27.2%). Ostieits fibrosa cystica was found in 04(3.88%) patients. Overall, Ultrasound neck and sestamibi scan localized the lesion in 66 (64.1%) and 77 (76.2%) patients respectively. Among 79 patients who underwent surgery, 67 (84.8%) patients had an adenoma, 05 (6.3%) had hyperplasia and 02(2.53%) patients had parathyroid carcinoma whereas histopathology was inconclusive in 5 (6.32%) out of the 79 surgically treated patients. Disease recurrence was seen in 13 out of 79(16.45%) patients who underwent surgery. Conclusion:Primary hyperparathyroidism is associated with significant morbidity in our population. Targeted measures like improving patient awareness, routine calcium screening, vitamin D supplementation and a high index of suspicion by the clinician may help in early diagnosis of the condition and thus reduce morbidity.

journal_name

Pak J Med Sci

authors

Fatima T,Das B,Sattar S,Islam N

doi

10.12669/pjms.36.6.2572

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1199-1203

issue

6

eissn

1682-024X

issn

1681-715X

pii

PJMS-36-1199

journal_volume

36

pub_type

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