Abstract：
BACKGROUND:Myosin-IIB is a non-muscle isoform in the brain with increased expression in the brains of diabetic rats. Chronic hyperglycemia caused by diabetes can impair learning and memory. Oral hypoglycemic agents such as glibenclamide have been used to control hyperglycemia. We report changes in the expression and distribution of myosin-IIB in the frontal cortex and hippocampus of diabetic rats treated with glibenclamide. METHODS:The brains were removed after 43 days of treatment with glibenclamide (6 mg/kg bw orally), homogenized and analyzed by Western blotting, qRT-PCR and immunohistochemistry. RESULTS:Myosin-IIB expression increased in the brains of diabetic rats. However, protein expression returned to control levels when treated with glibenclamide. In addition, the expression of MYH10 gene encoding non-muscle myosin heavy chain-B decreased in diabetic rats treated with glibenclamide. Moreover, we found weak myosin-IIB labeling in the hippocampus and frontal cortex of rats treated with glibenclamide. Therefore, the expression of myosin-IIB is affected by diabetes mellitus and may be modulated by glibenclamide treatment in rats. Structural changes in the hippocampus and prefrontal cortex are reversible, and glibenclamide treatment may reduce the patho-physiological changes in the brain. CONCLUSIONS:Our findings can contribute to the understanding of the regulation of myosins in the brains of diabetic rats.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
da Costa AV,Calábria LK,de Souza Santos P,Goulart LR,Espindola FSdoi
10.1016/j.jns.2014.03.020subject
Has Abstractpub_date
2014-05-15 00:00:00pages
159-64issue
1-2eissn
0022-510Xissn
1878-5883pii
S0022-510X(14)00164-6journal_volume
340pub_type
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