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Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19.

Abstract：

:We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care unit with severe COVID-19 undergoing brain MRI for evaluation of coma or neurologic deficits were retrospectively identified. Eleven patients had punctate susceptibility-weighted imaging (SWI) lesions in the subcortical and deep white matter, eight patients had >10 SWI lesions, and four patients had lesions involving the corpus callosum. The distribution of SWI lesions was similar to that seen in patients with hypoxic respiratory failure, sepsis, and disseminated intravascular coagulation. Brain autopsy in one patient revealed that SWI lesions corresponded to widespread microvascular injury, characterized by perivascular and parenchymal petechial hemorrhages and microscopic ischemic lesions. Collectively, these radiologic and histopathologic findings add to growing evidence that patients with severe COVID-19 are at risk for multifocal microvascular hemorrhagic and ischemic lesions in the subcortical and deep white matter.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Conklin J,Frosch MP,Mukerji SS,Rapalino O,Maher MD,Schaefer PW,Lev MH,Gonzalez RG,Das S,Champion SN,Magdamo C,Sen P,Harrold GK,Alabsi H,Normandin E,Shaw B,Lemieux JE,Sabeti PC,Branda JA,Brown EN,Westover MB,Huan

doi

10.1016/j.jns.2021.117308

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

117308

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(21)00001-0

journal_volume

421

pub_type

杂志文章

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