当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > The characteristics of camptocormia in patients with Parkinson's disease: A large cross-sectional multicenter study in Japan.

The characteristics of camptocormia in patients with Parkinson's disease: A large cross-sectional multicenter study in Japan.

Abstract：

PURPOSE:The goal of the present study was to clarify the clinical characteristics and laboratory results of parkinsonian symptoms among patients with and without camptocormia. METHODS:Seventy-eight Parkinson's disease (PD) patients with camptocormia and 78 PD patients without camptocormia underwent a neurological examination, a blood test, and spinal magnetic resonance imaging (MRI). PD with camptocormia group and PD with non-camptocormia group were matched on age, age at PD onset, and sex. PRINCIPAL RESULTS:Camptocormia group had significantly higher prevalence of compression fractures, more severe parkinsonian symptoms, and a greater incidence of dementia than those without camptocormia. Serum creatine kinase levels in camptocormia group significantly elevated compared with non-camptocormia group. There were higher prevalence of abnormal findings in spine MRI including compression fractures and paravertebral muscle changes in camptocormia group compared with non-camptocormia group. MAJOR CONCLUSIONS:Camptocormia is associated with a greater prevalence of compression fractures and associated with greater UPDRS part II, part III score, axial score, and lower MMSE in this cross-sectional study. Thus, it can be concluded that camptocormia in PD is predominantly myopathic.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Nakane S,Yoshioka M,Oda N,Tani T,Chida K,Suzuki M,Funakawa I,Inukai A,Hasegawa K,Kuroda K,Mizoguchi K,Shioya K,Sonoda Y,Matsuo H

doi

10.1016/j.jns.2015.09.015

subject

Has Abstract

pub_date

2015-11-15 00:00:00

pages

299-303

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(15)02095-X

journal_volume

358

pub_type

杂志文章,多中心研究

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