Abstract:
:Osterix belongs to the SP gene family and is a core transcription factor responsible for osteoblast differentiation and bone formation. Activation of protein kinase A (PKA), a serine/threonine kinase, is essential for controlling bone formation and BMP-induced osteoblast differentiation. However, the relationship between Osterix and PKA is still unclear. In this report, we investigated the precise role of the PKA pathway in regulating Osterix during osteoblast differentiation. We found that PKA increased the protein level of Osterix; PKA phosphorylated Osterix, increased protein stability, and enhanced the transcriptional activity of Osterix. These results suggest that Osterix is a novel target of PKA, and PKA modulates osteoblast differentiation partially through the regulation of Osterix.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
He S,Choi YH,Choi JK,Yeo CY,Chun C,Lee KYdoi
10.1002/jcb.24851subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1808-15issue
10eissn
0730-2312issn
1097-4644journal_volume
115pub_type
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