Glycyrrhizin improves p75NTR-associated sciatic nerve regeneration in a BALB/c mouse model.

abstract：:Multiple cellular components are involved in the complex pathological process following central nervous system (CNS) injury, including neurons, glial cells and endothelial cells. Previous studies and neurotherapeutic clinical trials have assessed the molecular mechanisms that underlie neuronal cell death following CNS...

journal_title：Experimental and therapeutic medicine

authors： Yang JS,Wei HX,Chen PP,Wu G

更新日期：2018-03-01 00:00:00

abstract：:Preeclampsia is a major cause of maternal and perinatal mortality and morbidity, characterized by gestational hypertension, proteinuria, systemic endothelial cell activation and an exaggerated inflammatory response. The precise cause of preeclampsia is not currently known; however, it is widely accepted that the patho...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Dai LI,Zhou R

更新日期：2015-05-01 00:00:00

abstract：:Ischemic stroke is a life-threatening complication with a high rate of morbidity. Circulating fatty acid binding protein 4 (FABP4) has been reported to be associated with the outcome of acute ischemic stroke. The present study aimed to illustrate the function of FABP4 in ischemic stroke. PC12 cells exposed to oxygen g...

journal_title：Experimental and therapeutic medicine

authors： Yang XL,Mi JH,Dong Q

更新日期：2021-03-01 00:00:00

abstract：:The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue-derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms of PD in animal models. However, the mechanisms of the antifibrotic effects of AD...

journal_title：Experimental and therapeutic medicine

authors： Jiang H,Gao Q,Che X,Zhu L,Zhang Z,Chen Y,Dai Y

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to investigate the effects of advanced glycation end-products (AGEs) on podocyte adhesion and the underlying mechanisms. Immortalized mouse podocytes were exposed to various conditions and podocyte adhesion was evaluated using a hexosaminidase assay. The expression levels of integrin-linked k...

journal_title：Experimental and therapeutic medicine

authors： Cheng C,Zheng Z,Shi C,Liu X,Ye Z,Lou T

更新日期：2013-12-01 00:00:00

abstract：:Alcohol use disorder (AUD) is a primary, chronic and relapsing disease of brain reward, motivation and memory, which is associated with several comorbidities, including major depression and post-traumatic stress disorder. It has been revealed that Ibudilast (IBUD), a dual inhibitor of phosphodiesterase-4 and -10 and o...

journal_title：Experimental and therapeutic medicine

authors： Petralia MC,Mazzon E,Mangano K,Fagone P,Di Marco R,Falzone L,Basile MS,Nicoletti F,Cavalli E

更新日期：2020-03-01 00:00:00

abstract：:The aim of the present study was to determine whether the myocardial protective function of Shenmai injection (SM) during ischemia/reperfusion (I/R) is attributable to its regulation of intracellular calcium (Ca2+) and phospholamban (PLB) levels. Cultured neonatal Sprague Dawley rat cardiomyocytes were used to compare...

journal_title：Experimental and therapeutic medicine

authors： Ye LF,Zheng YR,Wang LH

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to investigate the mucus secretion status of mature goblet cells following the application of mitomycin-C (MMC) in ileal neobladder rat models. Bladder substitution models were established in Sprague Dawley rats, which had been divided into five groups, namely the control (sham), norma...

journal_title：Experimental and therapeutic medicine

authors： Fan W,Yu Y,Shu J,Ming H,Li W,Fan Z

更新日期：2015-08-01 00:00:00

abstract：:Expression and clinical significance of serum amyloid A (SAA) and interleukin-6 (IL-6) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) were investigated. Fifty-one patients with AECOPD (acute group, AG) and 51 patients with stable chronic obstructive pulmonary disease (stable grou...

journal_title：Experimental and therapeutic medicine

authors： Wei Y,Wang S,Wang D,Liu C

更新日期：2020-03-01 00:00:00

abstract：:The present study aimed to compare the diagnostic value of contrast-enhanced magnetic resonance angiography (CE MRA) with 3D time-resolved imaging of contrast kinetics, color Doppler ultrasound (CDUS) and digital subtraction angiography (DSA) in extracranial carotid stenosis (CS). A total of 54 patients with symptomat...

journal_title：Experimental and therapeutic medicine

authors： Cui H,Yan R,Zhai Z,Ren J,Li Z,Li Q,Wang S

更新日期：2018-02-01 00:00:00

abstract：:We previously demonstrated that vitamin B6 suppresses tumorigenesis in the colon of mice and exerts an anti-inflammatory effect through the inhibition of NF-κB activation. As these effects resemble the pharmacological properties of thiazolidinedione (TZD), a synthetic peroxisome proliferator-activated receptor-γ (PPAR...

journal_title：Experimental and therapeutic medicine

authors： Yanaka N,Kanda M,Toya K,Suehiro H,Kato N

更新日期：2011-05-01 00:00:00

abstract：:Chronic exposure of workers to powder containing crystalline silica (Silicon dioxide; SiO2) can lead to chronic lung diseases (lung cancer, silicosis, etc.). Aim of this study was to evaluate the exposure of Greek construction workers to SiO2 and describe their pulmonary function. The study involved 86 outdoor and und...

journal_title：Experimental and therapeutic medicine

authors： Keramydas D,Bakakos P,Alchanatis M,Papalexis P,Konstantakopoulos I,Tavernaraki K,Dracopoulos V,Papadakis A,Pantazi E,Chelidonis G,Chaidoutis E,Constantinidis TC,Tsitsimpikou C,Kavantzas N,Patsouris E,Tsarouhas K,Spandidos

更新日期：2020-08-01 00:00:00

abstract：:Limited data exist concerning the long-term (≥5 year) survival rates of patients with stage IIIB and IV non-small cell lung carcinoma (NSCLC) receiving chemotherapy. We aimed to determine the long-term results of cisplatin plus third-generation (vinorelbine or gemcitabine) cytotoxic chemotherapy in patients with local...

journal_title：Experimental and therapeutic medicine

authors： Ozkaya S,Findik S,Dirican A,Atici AG

更新日期：2012-12-01 00:00:00

abstract：:UNBS5162, a naphthalimide derivative, has a strong anticancer effect and low clinical hematological toxicity. UNBS5162 has been shown to have an anticancer effect in numerous cancer types, except triple negative breast cancer (TNBC). To explore this issue, TNBC MDA-MB-231 cells were selected, and the effect of UNBS516...

journal_title：Experimental and therapeutic medicine

authors： Yue X,Li M,Chen D,Xu Z,Sun S

更新日期：2018-11-01 00:00:00

abstract：:In order to provide a scientific basis for rational use of antibiotics, we studied and compared the therapeutic effects of step-down and step-up antibiotic treatment schemes in children with lobar pneumonia. Eighty cases of children with lobar pneumonia were enrolled in this study and were randomly divided into two gr...

journal_title：Experimental and therapeutic medicine

authors： Li Y,Han F,Yang Y,Chu J

更新日期：2017-06-01 00:00:00

abstract：:MicroRNAs (miRs), a class of small non-coding RNAs, function as key regulators in gene expression through binding to the 3'-untranslated region (UTR) of their target mRNA, which further leads to translational repression or mRNA degradation. Recently, miR-138 has been found to have a tumor suppressive role in a variety...

journal_title：Experimental and therapeutic medicine

authors： Yuan Z,Mo H,Mo L,He J,Wu Z,Lin X

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to investigate the therapeutic effect of a combined treatment of Buyang Huanwu decoction (BYHWD), a well-known formula of traditional Chinese medicine, and neural stem cells (NSCs) on spinal cord injury (SCI) and the associated underlying mechanisms. A SCI model was established by surg...

journal_title：Experimental and therapeutic medicine

authors： Zhang M,Chai Y,Liu T,Xu N,Yang C

更新日期：2015-04-01 00:00:00

abstract：:Allicin has been reported to inhibit cancer cell proliferation, induce cell apoptosis and enhance the accumulation of reactive oxygen species. However, it has remained elusive whether allicin improves multidrug resistance in thyroid cancer cells through modulating autophagy. The present study demonstrated that combine...

journal_title：Experimental and therapeutic medicine

authors： Xiang Y,Zhao J,Zhao M,Wang K

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to investigate the effect of NVP-BEP800, a novel heat shock protein (Hsp) 90 inhibitor of the 2-aminothieno[2,3-d]pyrimidine class, in combination with radiation on glioblastoma cells. T98G human glioblastoma cells were treated with dimethyl sulfoxide (DMSO), NVP-BEP800, NVP-BEP800 in combinati...

journal_title：Experimental and therapeutic medicine

authors： Wu J,Wang W,Shao Q,Xiao G,Cheng J,Yuan Y,Zhang M

更新日期：2014-09-01 00:00:00

abstract：:The present study aimed to investigate changes in the levels of metabolites and appetite control factors caused by different dietary interventions in Sprague Dawley (SD) rats. A total of 35 male SD rats were weaned and immediately randomly assigned to five groups. The control group was given ad libitum access to a nor...

journal_title：Experimental and therapeutic medicine

authors： Lin B,Liu Y,Zhang W,Zou W

更新日期：2020-09-01 00:00:00

abstract：:This study aimed to assess the effect on solid tumors of mild temperature hyperthermia (MTH) combined with hexamethylenetetramine (HMTA) or tirapazamine (TPZ). Squamous cell carcinoma (SCC VII) tumor-bearing mice were continuously administered 5-bromo-2'-deoxyuridine (BrdU) to label intratumor proliferating (P) cells....

journal_title：Experimental and therapeutic medicine

authors： Masunaga SI,Tano K,Nakamura J,Watanabe M,Kashino G,Suzuki M,Kinashi Y,Ono K

更新日期：2010-01-01 00:00:00

abstract：:The aim of the present study was to investigate the feasibility of using composite scaffolds of poly(lactic-co-glycolic acid) (PLGA) and bioactive glass (BG) to repair bone defects. PLGA/BG composite scaffolds were prepared by thermally-induced phase separation. Scanning electron microscopy (SEM) was used to study the...

journal_title：Experimental and therapeutic medicine

authors： Yang L,Liu S,Fang W,Chen J,Chen Y

更新日期：2019-12-01 00:00:00

abstract：:Atrial remodeling is considered to be any persistent change in atrial structure or function, and is responsible for the development and perpetuation of atrial fibrillation (AF). Oxidative stress and intracellular pH regulation may also be linked to AF; however it remains unclear whether eicosapentaenoic acid (EPA) or ...

journal_title：Experimental and therapeutic medicine

authors： Tong M,Wang J,Ji Y,Chen X,Wang J,Wang S,Ruan L,Cui H,Zhou Y,Zhang Q,Watanabe E

更新日期：2017-09-01 00:00:00

abstract：:Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modification of hepatic phosp...

journal_title：Experimental and therapeutic medicine

authors： Yang H,Hwang I,Kim S,Hong EJ,Jeung EB

更新日期：2013-12-01 00:00:00

abstract：:The Chinese population are at an increased risk of autoimmune hepatitis (AIH). The aims of this study were to determine the demographic and clinical features of AIH in China. A total of 83 patients with AIH diagnosed by the revised scoring system were re-analyzed, and the clinical presentations among the different age...

journal_title：Experimental and therapeutic medicine

authors： Peng M,Li Y,Zhang M,Jiang Y,Xu Y,Tian Y,Peng F,Gong G

更新日期：2014-01-01 00:00:00

abstract：:Eyelid conditioning, including delay eyelid conditioning and trace eyelid conditioning, has been used extensively to study neural structures and mechanisms of learning and memory as a form of associative learning. In the present study, microcurrent electrical stimulation was used to stimulate the medial prefrontal cor...

journal_title：Experimental and therapeutic medicine

authors： Zheng YJ,Dong YC,Zhu C,Zhao MS

更新日期：2016-03-01 00:00:00

abstract：:Effects of triamcinolone acetonide (TA) combined with aminoguanidine (AG) on vascular endothelial function, vascular endothelial growth factor (VEGF) expression and retinal function in diabetic retinopathy (DR) patients were studied. A total of 100 patients with DR admitted to the Taizhou Second People's Hospital Affi...

journal_title：Experimental and therapeutic medicine

authors： Xu K,Qian H,Zou M

更新日期：2020-04-01 00:00:00

abstract：:The action mechanism of long non-coding ribonucleic acid-homeobox transcript antisense ribonucleic acid (lncRNA-HOTAIR) in the regulation of the Wnt signaling pathway on the drug resistance of non-small cell lung cancer was investigated. Forty eight patients with non-small cell lung cancer, who were treated with cispl...

journal_title：Experimental and therapeutic medicine

authors： Guo F,Cao Z,Guo H,Li S

更新日期：2018-06-01 00:00:00

abstract：:Primary lung enteric adenocarcinoma is a rare type of invasive lung carcinoma. Its morphology and immunohistochemistry are those of colorectal carcinoma, but there is no associated primary colorectal carcinoma. The present study describes the case of a 53-year-old female who presented with an irritating cough and a ma...

journal_title：Experimental and therapeutic medicine

authors： Lin LI,Xu CW,Zhang BO,Liu RR,Ge FJ,Zhao CH,Jia RU,Qin QH,Stojsic J,Wang Y,Xu JM

更新日期：2016-01-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is the most common congenital infection worldwide, and remains a significant cause of the neurological deficiency and sensory deafness in developed countries. Maternal primary infection, reactivation or reinfection during pregnancy may lead to fetal infection and congenital CMV syndrome...

journal_title：Experimental and therapeutic medicine

authors： Gorun F,Motoi S,Malita D,Navolan DB,Nemescu D,Olariu TR,Craina M,Vilibic-Cavlek T,Ciohat I,Boda D,Dobrescu A

更新日期：2020-09-01 00:00:00