Abstract:
OBJECTIVES:The purpose of this study was to investigate whether probiotics had an effect on proinflammatory markers and cytokines in overweight and obese individuals and whether they could have synergistic effects with weight-loss diets. METHODS:A total of 75 healthy overweight and obese individuals completed this randomized doubled-blind controlled clinical trial. Participants were randomly assigned to groups consuming regular yogurt with a low-calorie diet (LCD, RLCD; n = 25) or receiving probiotic yogurt with LCD (PLCD; n = 25) or consuming probiotic yogurt without LCD (PWLCD; n = 25) for 8 weeks. The pribiotic regimen contained 200 g/day yogurt, enriched by Lactobacillus acidophilus La5, Bifidobacterium BB12, and Lactobacillus casei DN001 10(8) colony-forming units/g. Body fat percentage, high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), leptin, and mRNA levels of inflammation-related genes (TNF-α and RAR-related orphan receptor gamma [ROR-γt]) in peripheral blood mononuclear cells (PBMCs) were measured. RESULTS:A reduction in body mass index (BMI), fat percentage, and leptin level was observed that was more obvious in groups who received the weight-loss diet with probiotic yogurt. Reduction in the gene expression of ROR-γt was significant in the PLCD group (p < 0.001). The expression of TNF-α did not change among all groups after intervention. The mean concentration of leptin was significantly decreased in all groups after the dietary intervention, but the mean changes in leptin level in the PLCD group was more prominent compared to the other two groups (-2.38, p < 0.001 [PLCD] vs -1.75, p = 0.002 [RLCD] and -0.55 ng/mL, p = 0.12 [PWLCD]). The reduction in serum levels of hs-CRP was more evident in the PWLCD group compared to the PLCD and RLCD groups after the 8-week intervention (-3.4, p = 0.03 vs -1.76, p < 0.001 and -2.98 pg/mL, p < 0.001, respectively). CONCLUSION:Our results suggested that the weight-loss diet and probiotic yogurt had synergistic effects on T-cells subset specific gene expression in PBMCs, fat percentage, and body weight among overweight and obese individuals.
journal_name
J Am Coll Nutrjournal_title
Journal of the American College of Nutritionauthors
Zarrati M,Salehi E,Nourijelyani K,Mofid V,Zadeh MJ,Najafi F,Ghaflati Z,Bidad K,Chamari M,Karimi M,Shidfar Fdoi
10.1080/07315724.2013.874937subject
Has Abstractpub_date
2014-01-01 00:00:00pages
417-25issue
6eissn
0731-5724issn
1541-1087journal_volume
33pub_type
杂志文章,随机对照试验abstract::Prevention of vascular disease and acute pancreatitis is the goal of hyperlipidemia treatment. The risk of coronary heart disease (CHD) increases with increasing plasma cholesterol levels because low-density lipoprotein (LDL), the major carrier of cholesterol in the plasma, is atherogenic. High-density lipoprotein (HD...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.1989.10737968
更新日期:1989-01-01 00:00:00
abstract::We collected 3-day dietary intake information from both incarcerated (n = 137) and nonincarcerated (n = 42) adolescent males to provide an objective assessment of diets of residents of a juvenile correctional facility. Average daily intake of energy, protein, 13 indicator micronutrients and of macronutrients as percen...
journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.1992.10718202
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abstract:OBJECTIVE:C-reactive protein (CRP) may directly affect the progression of atherosclerosis, and therefore, may be a target for reducing disease risk. The objective was to determine whether antioxidant supplementation reduces plasma CRP in active and passive smokers. DESIGN:Randomized, double-blind, placebo-controlled, ...
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pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.2004.10719354
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abstract::The inverse relationship between intake of dairy products and blood pressure levels was first suggested by several epidemiologic surveys in the early 1980's that revealed low calcium intake in populations with increased prevalence of hypertension. Subsequent laboratory and clinical investigations provided further evid...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.2000.10718085
更新日期:2000-04-01 00:00:00
abstract::Histidemia, first described by Ghadimi in 1961, is caused by a defect in histidase. The defect results in elevated urinary excretion of histidine and its transamination products, and in high blood histidine. Blood histidine levels in histidinemic patients range from 290 to 1420 microM (normal 70-120 microM). The clini...
journal_title:Journal of the American College of Nutrition
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abstract:OBJECTIVE:Zinc (Zn) and selenium (Se) are essential trace elements involved in thyroid hormone metabolism. This study was conducted to investigate the effects of Zn and Se supplementation on thyroid function of overweight or obese female hypothyroid patients in a double-blind, randomized controlled trial. METHODS:Sixt...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2014.926161
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.2017.1416312
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abstract:OBJECTIVE:Aging health is associated with nutritional changes which are not well understood and were therefore evaluated in this study by comparing the nutritional status of centenarians and elderly (in their 70s) relative to young subjects. SUBJECTS:The participants were 27 young subjects (10 males, 17 females), 40 h...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1999.10718876
更新日期:1999-08-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.1989.10720323
更新日期:1989-12-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2014.971193
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1983.10719906
更新日期:1983-01-01 00:00:00
abstract:UNLABELLED:Many publications indicate the beneficial effect of n-6 polyunsaturated fatty acids (n-6 PUFAs) in the control of coronary heart disease and diabetes, although the mechanism is not clear. Some of our previous results suggest that, in contrast to other lipids, n-6 PUFAs could have a permissive effect on carbo...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1987.10720202
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVES:Rheumatoid arthritis (RA) is an autoimmune disease characterized by an increase in some autoantibodies and proteolytic enzymes, leading to joint destruction. Although recent investigations have considered vitamin K as an anti-inflammatory nutrient with an important role in bone metabolism, there is currently...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2015.1026004
更新日期:2016-07-01 00:00:00
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.1999.10718842
更新日期:1999-04-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.2004.10719368
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journal_title:Journal of the American College of Nutrition
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.1993.10718284
更新日期:1993-02-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2011.10719977
更新日期:2011-10-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1409139
更新日期:2018-07-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1991.10718161
更新日期:1991-08-01 00:00:00
abstract::The determination of blood mononuclear cell magnesium content may be a predictor of total body magnesium status. Separation techniques employing Ficoll-Hypaque have been used for this assay; however, Hypaque contains a significant concentration of iodine that may be toxic to the cell membrane and affect the results. W...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1983.10719933
更新日期:1983-01-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
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更新日期:1995-06-01 00:00:00
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.2007.10719608
更新日期:2007-06-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2011.10719963
更新日期:2011-06-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.2011.10719988
更新日期:2011-10-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.1996.10718560
更新日期:1996-02-01 00:00:00