Abstract:
:Surgical resection of pancreatic cancer represents the only chance of cure and long-term survival in this common disease. Unfortunately, determination of a cancer-free margin at surgery is based on one or two tiny frozen section biopsies, which is far from ideal. Not surprisingly, cancer is usually left behind and is responsible for metastatic disease. We demonstrate a method of receptor-targeted imaging using peptide ligands, lipid microbubbles, and multiphoton microscopy that could lead to a fast and accurate way of examining the entire cut surface during surgery. Using a plectin-targeted microbubble, we performed a blinded in-vitro study to demonstrate avid binding of targeted microbubbles to pancreatic cancer cells but not noncancerous cell lines. Further work should lead to a much-needed point-of-care diagnostic test for determining clean margins in oncologic surgery.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Cromey B,McDaniel A,Matsunaga T,Vagner J,Kieu KQ,Banerjee Bdoi
10.1117/1.JBO.23.4.046501subject
Has Abstractpub_date
2018-04-01 00:00:00pages
1-8issue
4eissn
1083-3668issn
1560-2281pii
JBO-170811Rjournal_volume
23pub_type
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