Abstract:
INTRODUCTION:The prognostic value of peak V˙O2 and V˙E/V˙CO2 slope measured during cardiopulmonary exercise (CPX) testing has been well established in patients with advanced heart failure, but blood pressure response to exercise is less well characterized. METHODS:We retrospectively studied 151 outpatients who underwent CPX testing as part of an advanced heart failure evaluation. The outcome of interest was failure of medical management, defined by death, cardiac transplantation, or left ventricular assist device placement. Patients were stratified into tertiles by change in systolic blood pressure (SBP) (<13, 13-26, and ≥27 mm Hg) during exercise. RESULTS:Patients in the lowest tertile had the lowest peak V˙O2 (10.2 vs 10.6 vs 13.6 mL·kg·min, P = <0.001), the highest V˙E/V˙CO2 slope (42.8 vs 42.1 vs 36.3, P = 0.030), the shortest mean exercise time (5.1 vs 6.0 vs 7.0 min, P = <0.001), and the highest probability of failure of medical management at 1.5 yr (0.69 vs 0.41 vs 0.34, P = 0.011). After multivariate adjustment, increased SBP <20 mm Hg during exercise was associated with a lower hazard of medical management failure (hazard ratio = 0.96, 95% confidence interval [CI] = 0.934-0.987), whereas SBP increases >20 mm Hg were associated with an increased hazard (hazard ratio = 1.046, 95% CI = 1.018-1.075). CONCLUSION:In conclusion, changes in SBP during CPX testing provide additional prognostic information above standard clinical variables. The peculiar increase in risk noted in those with a rise in SBP >20 mm Hg is less clear and needs to be investigated further.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Il'giovine ZJ,Solomon N,Devore AD,Wojdyla D,Patel CB,Rogers JGdoi
10.1249/MSS.0000000000001587subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1345-1349issue
7eissn
0195-9131issn
1530-0315journal_volume
50pub_type
杂志文章abstract::The kinetics of gas exchange at the on-transient of exercise are appreciably slowed in older individuals. Eight older men (72 yr) completed 6 months of aerobic cycle training. Ventilation and gas exchange kinetics were determined at the onset of a below threshold (ventilatory threshold, V(E)T) square wave exercise fun...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::In the present studies, the Leuven Tennis Performance Test (LTPT), a newly developed test procedure to measure stroke performance in match-like conditions in elite tennis players, was evaluated as to its value for research purposes. The LTPT is enacted on a regular tennis court. It consists of first and second service...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199808000-00016
更新日期:1998-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine whether highly active antiretroviral therapy (HAART), rather than the direct effect of HIV infection, limits peripheral muscle oxygen extraction-utilization (a-vO(2)) in individuals infected with the human immunodeficiency virus (HIV). METHODS:Fifteen subjects (6 female a...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000074567.61400.93
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:The purpose of the present study was to examine the effect of increased protein intake on short-term decrements in endurance performance during a block of high-intensity training. METHODS:Trained male cyclists (VO(2max) = 64.2 ± 6.5 mL·kg(-1)·min(-1)) completed two 3-wk trials both divided equally into normal ...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/MSS.0b013e3181f684c9
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To examine the effect of an increase in roller ski rolling resistance on the physiological and upper body demands of roller skiing with the V2-alternate technique. METHODS:Nine highly skilled cross-country skiers roller skied at three paced speeds on a flat oval loop using roller skis with high (HiR) and low...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199805000-00018
更新日期:1998-05-01 00:00:00
abstract::The gravity-dependency and age-dependency of noradrenergic vasoconstrictor outflow to skeletal muscle (muscle sympathetic nerve activity; MSNA) in humans was analyzed by applying microneurography technique. The basal level of MSNA in the horizontally supine position increased with aging without significant changes in ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199610000-00039
更新日期:1996-10-01 00:00:00
abstract::Skeletal muscle is characterized by its ability to dynamically adapt to variable levels of functional demands. During periods of insufficient training stimulus, muscular detraining occurs. This may be characterized by a decreased capillary density, which could take place within 2--3 wk of inactivity. Arterial-venous o...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-200108000-00009
更新日期:2001-08-01 00:00:00
abstract::This study examined the effects of age and physical activity on body composition and fat distribution by comparing differences between young and older endurance trained men and women with differences between young and older sedentary people. Although indices of total body adiposity (fat mass, percent body fat) were hi...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::During the past three to four decades, a significant amount of data was collected to reinforce the notion that mitochondrial function is irrevocably linked to mitochondrial structure. Indeed, data from numerous studies have revealed several salient points of mitochondrial biology that include the following: 1). mitoch...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-200301000-00014
更新日期:2003-01-01 00:00:00
abstract::A variety of physiological responses, classified as local or central factors, have been suggested as providing the primary input for perception of effort during exercise. The potency of these responses as perceptual cues, however, has seldom been addressed in terms of relevant modifying variables such as exercise inte...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:Compelling evidence suggests larger performance decrements during hypoxic versus normoxic repeated sprinting. Yet the underlying mechanical alterations have not been thoroughly investigated. Therefore, we examined the effects of different levels of normobaric hypoxia on running mechanical performance during rep...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000000937
更新日期:2016-08-01 00:00:00
abstract::Oxidation-reduction (redox) based regulation of gene expression appears to be a fundamental regulatory mechanism in cell biology. This basic information has been exploited to develop novel strategies in clinical therapeutics. In contrast to the conventional idea that reactive species mostly serve as a trigger for oxid...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-200103000-00005
更新日期:2001-03-01 00:00:00
abstract:PURPOSE:To investigate the maximal physiological responses between aquatic and land-based graded exercise tests in overweight women. METHODS:Twenty healthy, overweight (body mass index (BMI) > or = 25 kg.m(-2)), Caucasian women (mean +/- SD; age 48 +/- 7 yr, BMI 30 +/- 4 kg.m(-2)) completed a deep water running (DWR) ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318164d0e0
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:Considering the different loading and training characteristics of the sports practiced during growth, it is important to specify and categorize the bone and soft tissue adaptations in adolescent athletes. This study aimed to categorize 10 different loading sports and a nonsport group and identify the difference...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002420
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate physical performance (static and dynamic) of U.S. Air Force reservists after an eastbound air travel across seven time zones and to estimate the pharmacological aids slow-release caffeine and melatonin versus placebo in attempt to overcome the decline in performance. M...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200104000-00018
更新日期:2001-04-01 00:00:00
abstract::It has been suggested that television watching and physical activity are related to obesity. This association, however, has been investigated mainly in children. This study provided the opportunity to examine the relationship between television watching, physical activity, and body mass index in adult Pima Indians, a ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199707000-00010
更新日期:1997-07-01 00:00:00
abstract:UNLABELLED:Exertional heat stroke (EHS) is a state of extreme hyperthermia that occurs when excess heat that is generated by muscular exercise exceeds the body's ability to dissipate it at the same rate. EHS is thought to coincide with previously healthy, highly motivated, and relatively untrained individuals exerting ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199902000-00004
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare architectural characteristics of leg muscles of sprinters and distance runners. METHODS:Skeletal muscle architectural characteristics were studied in 23 elite male 100-m sprinters (SPR, 10.0-10.9 s for 100 m), 24 elite male distance runners (DR, 13.5-14.5 min for 5000 m...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200006000-00014
更新日期:2000-06-01 00:00:00
abstract:PURPOSE:Overtraining is primarily related to sustained high load training, often coupled with other stressors. Studies in animal models have suggested that unremittingly heavy training (monotonous training) may increase the likelihood of developing overtraining syndrome. The purpose of this study was to extend our prel...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199807000-00023
更新日期:1998-07-01 00:00:00
abstract:PURPOSE:The magnitude of atrophy and strength loss induced by partial or complete disuse of skeletal muscles varies greatly among individuals. Factors predisposing some individuals to more extreme responses have not been identified. The purpose of this investigation was to determine whether 1) level of activity before ...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.mss.0000176302.99185.be
更新日期:2005-11-01 00:00:00
abstract::The field of developmental neurobiology is entering a very exciting phase, in which the application of new techniques promises to lead to major advances in our understanding of basic developmental processes. There is a need to apply much of this new knowledge to problems of spinal cord and muscle development, about wh...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1985-02-01 00:00:00
abstract::Anaerobic threshold (AT) and Vo2max were determined by automated analysis for 25 members of the 1980 U.S. Olympic Rowing Team during a progressive rowing ergometer exercise to exhaustion. Heart rates and power outputs were also measured to gauge severity of the exercise and to compare with metabolic data. Power increm...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198206000-00006
更新日期:1982-01-01 00:00:00
abstract:PURPOSES:To compare the claudication distances between men and women patients with peripheral arterial disease (PAD), and to determine whether sex differences in claudication pain persisted after controlling for potential confounders such as demographic, functional, and physiological measures. METHODS:A total of 488 m...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200211000-00001
更新日期:2002-11-01 00:00:00
abstract::We examined illness patterns in a cohort of 530 male and female runners who completed a monthly log for 12 months. The average number of upper respiratory tract infections (URTIs) per person per year for the cohort was 1.2. An upper respiratory tract infection was indicated by the report of any of the following sympto...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract:INTRODUCTION:Physical endurance can be limited by muscle glycogen stores, in that glycogen depletion markedly reduces external work. During carbohydrate restriction, the liver synthesizes the ketone bodies, D-β-hydroxybutyrate, and acetoacetate from fatty acids. In animals and in the presence of glucose, D-β-hydroxybut...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000001292
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Recent data indicate a direct relationship between the sympathetic nervous system and bone metabolism. The purpose of this study was to evaluate the effects of a beta-1 adrenergic (Adrb1) agonist, dobutamine (DOB), on disuse-induced changes in bone integrity during 28 d of hindlimb unloading (HU). METHODS...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31828d39bc
更新日期:2013-09-01 00:00:00
abstract::The utility of a biomechanical evaluation of an injury is shown for an incident involving bilateral tibial spiral fractures during skiing. With incorporation of directly measured binding release forces into a biomechanical model, estimates of torques transmitted to the skier's leg were determined. The analysis reveale...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198104000-00007
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:The effects of chronic exercise training on the expression of heat shock protein (HSP) in skeletal muscle of senescent animals are unknown. Therefore, the purpose of this study was to investigate the effects of chronic exercise training on skeletal muscle HSP expression in both young and old rats. METHODS:Youn...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200105000-00008
更新日期:2001-05-01 00:00:00
abstract::Exercise represents the primary countermeasure used during spaceflight to maintain or restore maximal aerobic capacity (VO2max), musculoskeletal structure, and orthostatic function. However, no single exercise or combination of prescriptions has proven entirely effective in restoring cardiovascular and musculoskeletal...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-199608000-00010
更新日期:1996-08-01 00:00:00
abstract::To discriminate suitable fire fighters from recurring large groups of applicants, an objective test battery was developed which screened applicants on the basis of physical, psychomotor, and mental abilities. The physical and psychomotor selection procedures first involved fundamental tests of general aerobic enduranc...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198512000-00007
更新日期:1985-12-01 00:00:00