Mitochondria: biogenesis, structure, and function--symposium introduction.

Abstract:

:During the past three to four decades, a significant amount of data was collected to reinforce the notion that mitochondrial function is irrevocably linked to mitochondrial structure. Indeed, data from numerous studies have revealed several salient points of mitochondrial biology that include the following: 1). mitochondria exist as a reticulum rather than as single entities, 2). different mitochondrial populations identified by their cellular location are characterized by different structural and functional characteristics, and 3). muscle mitochondrial respiratory capacity readily adapts to changes in muscle use and disuse by adjusting tissue metabolic capacity to match functional demands. More recently, research in the area of mitochondrial biology has focused on uncovering 1). the cellular signals responsible for the control of mitochondrial biogenesis via coordinate regulation of nuclear and mitochondrial gene expression, 2). the mechanisms by which mitochondrial respiration is regulated, and 3). the role of mitochondria in apoptotic cell death. The most current knowledge in these areas of mitochondrial biology will be addressed in the following symposium papers.

journal_name

Med Sci Sports Exerc

authors

Turcotte LP

doi

10.1097/00005768-200301000-00014

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

82-5

issue

1

eissn

0195-9131

issn

1530-0315

journal_volume

35

pub_type

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