Abstract:
INTRODUCTION:Recent data indicate a direct relationship between the sympathetic nervous system and bone metabolism. The purpose of this study was to evaluate the effects of a beta-1 adrenergic (Adrb1) agonist, dobutamine (DOB), on disuse-induced changes in bone integrity during 28 d of hindlimb unloading (HU). METHODS:Male Sprague-Dawley rats, age 6 months, were assigned to either a normal cage activity (CC) or HU (n = 24/group). Animals were given one daily bolus dose (4 mg·kg body weight a day) of DOB (n = 12) or an equal volume of saline (VEH, n = 12). RESULTS:In vivo peripheral quantitative computed tomography scans revealed a 9% loss in proximal tibia metaphysis (PTM) volumetric bone mineral density (vBMD) over 28 d of disuse. DOB administration during HU significantly attenuated reductions in PTM vBMD and inhibited reductions in mid-diaphysis tibia cross-sectional moment of inertia. A significant decline in PTM bone formation rate in the HU-VEH group (-56% vs CC-VEH) was completely abolished in the HU-DOB group. Significant reductions in strength of the femoral shaft and neck in the HU-VEH group (14% and 15%, respectively) were prevented with DOB treatment. CONCLUSION:In conclusion, DOB administration during HU effectively attenuates significant declines in total vBMD at PTM by mitigating associated decrements in bone formation rate. Positive effects of DOB were observed only in unloaded animals, with no effects observed in normal weight-bearing rats. These data provide evidence for the importance of Adrb1 signaling in maintaining osteoblast function during periods of mechanical unloading.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Swift JM,Hogan HA,Bloomfield SAdoi
10.1249/MSS.0b013e31828d39bcsubject
Has Abstractpub_date
2013-09-01 00:00:00pages
1665-73issue
9eissn
0195-9131issn
1530-0315journal_volume
45pub_type
杂志文章abstract::Maximal lactate steady state (MLSS) refers to the upper limit of blood lactate concentration indicating an equilibrium between lactate production and lactate elimination during constant workload. The aim of the present study was to investigate whether different levels of MLSS may explain different blood lactate concen...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199602000-00013
更新日期:1996-02-01 00:00:00
abstract:PURPOSE:There is interest in the potential long-term use of dietary supplementation with bovine colostrum to enhance exercise performance. The purpose of the present study was to determine the dose effects of bovine colostrum on cycling performance. METHODS:Forty-two competitive cyclists were randomly divided into thr...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200207000-00020
更新日期:2002-07-01 00:00:00
abstract:PURPOSE:Exercise training restores innate immune system cell function in post-myocardial infarction (post-MI) rats. However, studies of the involvement of lymphocyte (Ly) in the setting of the congestive heart failure (CHF) are few. To address this issue, we investigated the function of Ly obtained from cervical lymph ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31815ed6d2
更新日期:2008-03-01 00:00:00
abstract::We examined whether the relation between of ratings of perceived exertion (RPE) and exercise intensities associated with the lactate threshold (LT) and blood lactate concentrations (BLC) of 2.5 and 4.0 mM, established with an incremental protocol, held during 30-min treadmill run at constant velocity (V). RPE (11.6, 1...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-199406000-00021
更新日期:1994-06-01 00:00:00
abstract::Sudden cardiac death is always a tragedy. Sudden death during sport is particularly poignant because people tend to associate sport with health and fitness. Both the public and the medical profession would like to prevent such events, and preparticipation medical screening is often promoted as one such method. When we...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-199810001-00002
更新日期:1998-10-01 00:00:00
abstract::The present investigation tested the hypotheses that there would be greater prevalence of expiratory flow limitation (EFL) in endurance-trained (ET) youth cyclists compared with a recreationally active control (CON) group. METHODS:Twelve ET youth male cyclists (16.3 ± 1.0 yr (13-18 yr), 176.5 ± 6.2 cm, 64.2 ± 5.9 kg)...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002325
更新日期:2020-09-01 00:00:00
abstract:UNLABELLED:Migrating birds have been able to sustain an energy expenditure (EE) that is five times their basal metabolic rate. Although humans can readily reach these levels, it is not yet clear what levels can be sustained for several days. PURPOSE:The study's purposes were 1) to determine the upper limits of human E...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,meta分析,评审
doi:10.1249/MSS.0b013e31822430ed
更新日期:2011-12-01 00:00:00
abstract:INTRODUCTION:Gastroesophageal reflux disease is a disorder in which gastric contents move from stomach to esophagus. Exercise is a recognized contributing factor to reflux in healthy volunteers and is reported to be proportional to exercise intensity and the type of exercise. Our aim was to explore changes in physiolog...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000064937.99001.56
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:Lower-limb muscle weakness has often been reported in COPD, and contributes to exercise intolerance. Controversial information is available regarding upper-limb muscle adaptations and the influence of muscle wasting on muscle weakness. We investigated leg and arm muscle function in 59 stable COPD patients (GOLD...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.mss.0000150082.59155.4f
更新日期:2005-01-01 00:00:00
abstract::Red blood cells obtained from well-trained athletes consumed glucose at a higher rate than those from sedentary subjects when incubated in vitro in a glucose containing medium at 37 degrees C. Similar results were obtained when fructose was substituted for glucose, but not when galactose was the monosaccharide. The ut...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:This study was designed to determine changes in metabolic and cardiovascular risk factors following normobaric hypoxic exercise training in healthy men. METHODS:Following a randomized baseline maximal exercise test in hypoxia and/or normoxia, 34 physically active subjects were randomly assigned to either a nor...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-200006000-00004
更新日期:2000-06-01 00:00:00
abstract:INTRODUCTION:Chronic unimanual motor practice increases the motor output not only in the trained but also in the nonexercised homologous muscle in the opposite limb. We examined the hypothesis that adaptations in motor cortical excitability of the nontrained primary motor cortex (iM1) and in interhemispheric inhibition...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0b013e31820a94b8
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:The increased physiological demand of pregnancy results in profound adaptation of the maternal cardiovascular system, reflected by greater resting cardiac output and left ventricular (LV) deformation. Whether the increased resting demand alters acute cardiac responses to exercise in healthy pregnant women is no...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002554
更新日期:2020-11-03 00:00:00
abstract:INTRODUCTION/PURPOSE:Cycling is associated with a reproducible systolic anterograde and diastolic retrograde flow pattern in the brachial artery (BA) of the inactive upper limb, which results in endothelial nitric oxide (NO) release. The purpose of this study was to examine the impact of different types and intensities...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181923957
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:To compare training loads between men and women during 14 wk of British Army standard entry basic training. METHODS:Thirty-one male (mean ± SD: age, 21 ± 4 yr; height, 1.78 ± 0.08 m; mass, 77.1 ± 10.5 kg) and 28 female (age, 22 ± 4 yr; height, 1.65 ± 0.05 m; mass, 63.9 ± 8.9 kg) British Army recruits had exter...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001716
更新日期:2018-12-01 00:00:00
abstract::Changes in body composition, fat distribution and lipoprotein lipids in response to weight loss elicited by a 10-month program of hypocaloric diet (HD) therapy alone or combined with aerobic exercise training (AEX+HD) were examined in sedentary obese older males. Body composition was assessed by hydrodensitometry and ...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:PURPOSE:This study aimed to analyze the influence of foot strike pattern on running economy and biomechanical characteristics in subelite runners with a similar performance level. METHODS:Twenty subelite long-distance runners participated and were divided into two groups according to their foot strike pattern: rearfoo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000139
更新日期:2014-03-01 00:00:00
abstract:INTRODUCTION:Loud sounds can decrease reaction time (RT) and increase force generated during voluntary contractions. Accordingly, we hypothesized that the loud starter's pistol at the Olympic Games allows runners closer to the starter to react sooner and stronger than runners farther away. METHODS:RT for the 100/110 m...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31816770e1
更新日期:2008-06-01 00:00:00
abstract:PURPOSE AND METHODS:It is commonly recognized that there is familial aggregation for physical activity level. However, the genes and sequence variants responsible for the familial clustering have not been investigated. We performed a genome-wide linkage scan based on 432 markers typed in 767 subjects from 207 families ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000078937.22939.7E
更新日期:2003-08-01 00:00:00
abstract::Although no conclusive evidence exists to suggest that vitamin supplementation improves athletic performance in nutritionally adequate individuals, exercise may increase requirements for certain vitamins in individuals with marginal vitamin stores. This review summarizes results from recent research studies of vitamin...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract::Cardiovascular responses were obtained during cycling with graded levels of lower-body positive pressure (LBPP) applied to the exercising limbs. Seven men performed four incremental work rate (25 W.min-1) exercise (IWREx) tests to their limit of tolerance while exposed to 0, 15, 30, or 45 Torr LBPP. They also performe...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-199406000-00008
更新日期:1994-06-01 00:00:00
abstract::This study examined the effects of age and physical activity on body composition and fat distribution by comparing differences between young and older endurance trained men and women with differences between young and older sedentary people. Although indices of total body adiposity (fat mass, percent body fat) were hi...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract:PURPOSE:To validate the 7-d Physical Activity Recall (PAR) telephone interview version and its activity intensity categories. METHODS:Seventy-four adults (47 women, 27 men), ranging in age (18-67) and activity levels, were interviewed by phone and in-person using the same PAR protocol. Each participant wore a TriTrac-...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000064941.43869.4E
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:The prevalences of diabetes, hypertension, and high cholesterol all decrease with increased levels of physical activity and cardiorespiratory fitness. Whether these reductions extend beyond contemporary guideline activity levels and whether fitness affects medication use independent of activity, remains unclear...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/mss.0b013e318145b337
更新日期:2007-11-01 00:00:00
abstract::The inheritance of cardiac changes during acute dynamic physical exercise was studied in 21 pairs of monozygotic and 12 pairs of dizygotic male twins, ages 18-31 yr. Echocardiography was performed in resting conditions and at submaximal supine bicycle exercise at a heart rate of 110 bpm. In resting conditions signific...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract:PURPOSE:The purpose of the current study was to investigate the associations between the GNB3 C825T polymorphism, body fatness and fitness, and blood pressure in a sample of young Korean men. METHODS:A total of 282 apparently healthy Korean men (nonobese N = 152, obese N = 130) aged 19-33 yr participated in the study....
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000170096.96662.05
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:This prospective magnetic resonance (MR) imaging study investigated the development of symptomatic pars lesions in the lumbar spine of adolescent cricket fast bowlers. METHODS:Annual MR examinations of the lumbar spine in male fast bowlers (N = 51) and swimmers (N = 20) without a prestudy history of symptomati...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000241642.82725.ac
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:There is a lack of robust evidence to support a daily step count target that equates to current physical activity guidelines in children and youth. This information would be useful to researchers and practitioners who are using pedometers to monitor physical activity. METHODS:Accelerometer and pedometer data c...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31823f23b1
更新日期:2012-05-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to validate a parent proxy record of children's physical activity with CSA Model 7164 accelerometers. METHODS:A parent proxy record was developed to record children's activity after school on weekdays and all day long on weekends for 7 d. Parents recorded both duration and in...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000174906.38722.2e
更新日期:2005-08-01 00:00:00
abstract:UNLABELLED:Uncoupling protein 3 (UCP3) is a mitochondrial inner membrane protein, which is hypothesized to shuttle nonmetabolized fatty acids, particularly when excessive fatty acids are present. PURPOSE:Obese Zucker rats (OZR) have systematically elevated levels of fatty acids, with decreased fatty acid metabolism. W...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31817702a4
更新日期:2008-09-01 00:00:00