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Correlation between plasma cortisol and CSF catecholamines in endogenous depressed dexamethasone nonsuppressors.

Abstract：

:Nineteen endogenous depressive in-patients (13 with major depression and 6 with bipolar disorder-depressed) and 10 other patients with dysthymic disorder serving as the control group were given the dexamethasone suppression test (DST, 1 mg/subject). The results showed that the DST sensitivity in endogenous depressives was 73.7% and the specificity was 90%. After the patients were treated daily for 6 weeks with 150-200 mg imipramine, 88.9% of those endogenous depressive patients who previously had a positive DST response exhibited a negative response. Moreover, a significantly negative correlation was found between the CSF norepinephrine level and the pre-dexamethasone 4 p.m. plasma cortisol level in those endogenous depressed patients who had a positive DST response. Pre-treatment data also showed that the 4 p.m. plasma cortisol had a significant negative correlation with CSF dopamine. These findings suggest that endogenous depression with positive DST could be related not only to a lower norepinephrine level, but also to a lower dopamine level.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Lu RB,Ho SL,Ho BT,Leu SY,Shian LR,Chen WL

doi

10.1016/0165-0327(86)90002-9

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

177-84

issue

3

eissn

0165-0327

issn

1573-2517

pii

0165-0327(86)90002-9

journal_volume

10

pub_type

杂志文章

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