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Remote ischemic conditioning.

Abstract：

:In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and render remote tissues and organs resistant to ischemia/reperfusion injury. The peripheral stimulus can be chemical, mechanical, or electrical and involves activation of peripheral sensory nerves. The signal transfer to the heart or other organs is through neuronal and humoral communications. Protection can be transferred, even across species, with plasma-derived dialysate and involves nitric oxide, stromal derived factor-1α, microribonucleic acid-144, but also other, not yet identified factors. Intracardiac signal transduction involves: adenosine, bradykinin, cytokines, and chemokines, which activate specific receptors; intracellular kinases; and mitochondrial function. RIC by repeated brief inflation/deflation of a blood pressure cuff protects against endothelial dysfunction and myocardial injury in percutaneous coronary interventions, coronary artery bypass grafting, and reperfused acute myocardial infarction. RIC is safe and effective, noninvasive, easily feasible, and inexpensive.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Heusch G,Bøtker HE,Przyklenk K,Redington A,Yellon D

doi

10.1016/j.jacc.2014.10.031

subject

Has Abstract

pub_date

2015-01-20 00:00:00

pages

177-95

issue

2

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(14)06858-2

journal_volume

65

pub_type

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