Experimental validation of circumferential, longitudinal, and radial 2-dimensional strain during dobutamine stress echocardiography in ischemic conditions.


OBJECTIVES:The aim of this study was to assess and validate 2-dimensional (2D) strain for the detection of ischemia during dobutamine stress echocardiography (DSE). BACKGROUND:Evaluation of abnormalities of left ventricular (LV) function from wall thickening during DSE is unsatisfactory and requires a high level of expertise. METHODS:In 10 open-chest anesthetized pigs, myocardial deformation was studied before and during dobutamine infusion, under control and ischemic conditions produced by various degrees of coronary artery constriction: 2 of nonflow-limiting stenoses (NFLS) of increasing severity reducing left anterior descending artery hyperemic flow by 40% and 70% and 2 flow-limiting stenoses (FLS) reducing resting coronary flow by 25% and 50%. Agreement between 2D strain echocardiography and sonomicrometry (reference method) was evaluated by linear regression and Bland-Altman analysis. RESULTS:Good correlation and agreement were observed between 2-dimensional strain and sonomicrometry at rest and during dobutamine infusion; longitudinal strain: r = 0.77, p < 0.001 and r = 0.80, p < 0.001; radial strain: r = 0.57, p < 0.05 and r = 0.63, p < 0.05; and circumferential strain: r = 0.74, p < 0.001 and r = 0.58, p < 0.001. Circumferential and longitudinal strains in the risk area were significantly decreased at rest in the presence of FLS and during dobutamine infusion in the presence of NFLS. By contrast, radial strain was significantly decreased in the presence of severe FLS only during dobutamine infusion. CONCLUSIONS:The 2D strain provides accurate assessment of LV regional function. Evaluation of circumferential and longitudinal strains during DSE has real potential for quantitative evaluation of LV deformation in the routine assessment of ischemia.


J Am Coll Cardiol


Reant P,Labrousse L,Lafitte S,Bordachar P,Pillois X,Tariosse L,Bonoron-Adele S,Padois P,Deville C,Roudaut R,Dos Santos P




Has Abstract


2008-01-15 00:00:00














  • Reverse remodeling and enhanced adrenergic reserve from passive external support in experimental dilated heart failure.

    abstract:OBJECTIVES:We sought to test the efficacy of a passive elastic containment device to reverse chronic chamber remodeling and adrenergic down-regulation in the failing heart, yet still maintaining preload reserve. BACKGROUND:Progressive cardiac remodeling due to heart failure is thought to exacerbate underlying myocardi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Saavedra WF,Tunin RS,Paolocci N,Mishima T,Suzuki G,Emala CW,Chaudhry PA,Anagnostopoulos P,Gupta RC,Sabbah HN,Kass DA

    更新日期:2002-06-19 00:00:00

  • Economics of elective coronary revascularization. Comparison of costs and charges for conventional angioplasty, directional atherectomy, stenting and bypass surgery.

    abstract:OBJECTIVES:This study was designed to evaluate more closely the true in-hospital costs of elective revascularization by directional coronary atherectomy and intracoronary stenting and to compare these costs with those of the traditional revascularization alternatives (i.e., conventional balloon angioplasty and coronary...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Cohen DJ,Breall JA,Ho KK,Weintraub RM,Kuntz RE,Weinstein MC,Baim DS

    更新日期:1993-10-01 00:00:00

  • Associations among androgens, estrogens, and natriuretic peptides in young women: observations from the Dallas Heart Study.

    abstract:OBJECTIVES:We sought to determine if natriuretic peptides are associated with estrogen and androgen status in a population study of young women without known cardiac disease. BACKGROUND:Circulating concentrations of plasma B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are higher in women than in m...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Chang AY,Abdullah SM,Jain T,Stanek HG,Das SR,McGuire DK,Auchus RJ,de Lemos JA

    更新日期:2007-01-02 00:00:00

  • Coronary artery calcium to predict all-cause mortality in elderly men and women.

    abstract:OBJECTIVES:We sought to study the prognostic utility of coronary artery calcium (CAC) in the elderly. BACKGROUND:The prognostic significance of CAC in the elderly is not well known. METHODS:All-cause mortality was assessed in 35,388 patients (3,570 were >or=70 years old at screening, and 50% were women) after a mean ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Raggi P,Gongora MC,Gopal A,Callister TQ,Budoff M,Shaw LJ

    更新日期:2008-07-01 00:00:00

  • The signal-averaged electrocardiogram and ventricular arrhythmias after thrombolysis for acute myocardial infarction.

    abstract::The prevalence of an abnormal signal-averaged electrocardiogram (ECG) and ventricular arrhythmias on 24 h ambulatory electrocardiography was evaluated in 118 patients 13 +/- 2 days after acute myocardial infarction. Group 1 (46 patients) underwent intravenous thrombolysis within 6 h of the onset of symptoms, whereas G...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Turitto G,Risa AL,Zanchi E,Prati PL

    更新日期:1990-05-01 00:00:00

  • Subcutaneous administration of brain natriuretic peptide in experimental heart failure.

    abstract:OBJECTIVES:The objective of this investigation was to define for the first time the cardiorenal and humoral actions of repeated short-term administration of subcutaneous (SQ) brain natriuretic peptide (BNP) administration during the evolution of experimental heart failure. BACKGROUND:The rationale of this study was ba...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Chen HH,Grantham JA,Schirger JA,Jougasaki M,Redfield MM,Burnett JC Jr

    更新日期:2000-11-01 00:00:00

  • The association among renal insufficiency, pharmacotherapy, and outcomes in 6,427 patients with heart failure and coronary artery disease.

    abstract:OBJECTIVES:This study was designed to examine the use of cardiovascular medications and outcomes in patients with heart failure (HF) and renal dysfunction. BACKGROUND:Renal insufficiency is associated with poorer outcomes in patients with HF, but the mechanisms are uncertain. In particular, the degree of therapeutic n...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Ezekowitz J,McAlister FA,Humphries KH,Norris CM,Tonelli M,Ghali WA,Knudtson ML,APPROACH Investigators.

    更新日期:2004-10-19 00:00:00

  • Long-Term Use of Cardiovascular Drugs: Challenges for Research and for Patient Care.

    abstract::Little is known about the benefits and risks of the long-term use of cardiovascular drugs. Evidence from randomized clinical trials (RCTs) rarely goes beyond a few years of follow-up, but patients are often given continuous treatment with multiple drugs well into old age. We focus on 4 commonly used cardiovascular dru...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审


    authors: Rossello X,Pocock SJ,Julian DG

    更新日期:2015-09-15 00:00:00

  • The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study.

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    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Gurbel PA,Bliden KP,Logan DK,Kereiakes DJ,Lasseter KC,White A,Angiolillo DJ,Nolin TD,Maa JF,Bailey WL,Jakubowski JA,Ojeh CK,Jeong YH,Tantry US,Baker BA

    更新日期:2013-08-06 00:00:00

  • Gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the United States.

    abstract:BACKGROUND:Rates of referral to cardiac rehabilitation after percutaneous coronary intervention (PCI) have been historically low despite the evidence that rehabilitation is associated with lower mortality in PCI patients. OBJECTIVES:This study sought to determine the prevalence of and factors associated with referral ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究


    authors: Aragam KG,Dai D,Neely ML,Bhatt DL,Roe MT,Rumsfeld JS,Gurm HS

    更新日期:2015-05-19 00:00:00

  • Arrhythmias after the Mustard operation for transposition of the great arteries: a long-term study.

    abstract::This study presents follow-up data on 95 patients with transposition of the great arteries who underwent a Mustard intraatrial baffle operation. The patients were followed up serially by means of scalar electrocardiograms and 24 hour Holter monitoring studies. The latter study was effective in documenting abnormal rhy...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Hayes CJ,Gersony WM

    更新日期:1986-01-01 00:00:00

  • Predicting the Unpredictable: Drug-Induced QT Prolongation and Torsades de Pointes.

    abstract::Drug-induced long QT syndrome (diLQTS) and congenital LQTS (cLQTS) share many features, and both syndromes can result in life-threatening torsades de pointes (TdP). Our understanding of their mechanistic and genetic similarities has led to their improved clinical management. However, our inability to prevent diLQTS ha...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审


    authors: Schwartz PJ,Woosley RL

    更新日期:2016-04-05 00:00:00

  • A Simple Disease-Guided Approach to Personalize ACC/AHA-Recommended Statin Allocation in Elderly People: The BioImage Study.

    abstract:BACKGROUND:The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines recommend primary prevention with statins for individuals with ≥7.5% 10-year risk for atherosclerotic cardiovascular disease (ASCVD). Everyone living long enough will become eligible for risk-based statin therapy due to...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Mortensen MB,Fuster V,Muntendam P,Mehran R,Baber U,Sartori S,Falk E

    更新日期:2016-08-30 00:00:00

  • Diffuse myocardial fibrosis evaluated by post-contrast t1 mapping correlates with left ventricular stiffness.

    abstract:OBJECTIVES:The purpose of this study was to use cardiac magnetic resonance (CMR) imaging and invasive left ventricular (LV) pressure-volume (PV) measurements to explore the relationship between diffuse myocardial fibrosis and indexes of diastolic performance in a cohort of cardiac transplant recipients. BACKGROUND:The...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Ellims AH,Shaw JA,Stub D,Iles LM,Hare JL,Slavin GS,Kaye DM,Taylor AJ

    更新日期:2014-03-25 00:00:00

  • Influence of treatment modality on angiographic outcome after coronary stenting in diabetic patients: a controlled study.

    abstract:OBJECTIVES:This retrospective study was designed to determine the six-month angiographic outcome after stenting of native coronary arteries in insulin-treated (ITDM) and non-ITDM patients with diabetes mellitus (DM) and compare the results with those in non-DM patients. BACKGROUND:The influence of the treatment modali...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Schofer J,Schlüter M,Rau T,Hammer F,Haag N,Mathey DG

    更新日期:2000-05-01 00:00:00

  • Gender differences and normal left ventricular anatomy in an adult population free of hypertension. A cardiovascular magnetic resonance study of the Framingham Heart Study Offspring cohort.

    abstract:OBJECTIVES:We sought to derive gender-specific cardiovascular magnetic resonance (CMR) reference values for normative left ventricular (LV) anatomy and function in a healthy adult population of clinically relevant age. BACKGROUND:Cardiovascular magnetic resonance imaging is increasingly applied in the clinical setting...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Salton CJ,Chuang ML,O'Donnell CJ,Kupka MJ,Larson MG,Kissinger KV,Edelman RR,Levy D,Manning WJ

    更新日期:2002-03-20 00:00:00

  • The detection of viral genomes by polymerase chain reaction in the myocardium of pediatric patients with advanced HIV disease.

    abstract:OBJECTIVES:The aim of this study was to investigate the frequency of viral nucleic acid detection in the myocardium of human immunodeficiency virus (HIV)-infected children to determine whether an association exists with the development of heart disease. BACKGROUND:As improved medical interventions increase the life ex...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Bowles NE,Kearney DL,Ni J,Perez-Atayde AR,Kline MW,Bricker JT,Ayres NA,Lipshultz SE,Shearer WT,Towbin JA

    更新日期:1999-09-01 00:00:00

  • Determination of pulmonary to systemic blood flow ratio in children by a simplified Doppler echocardiographic method.

    abstract::Doppler echocardiographic determination of the pulmonary to systemic blood flow (Qp/Qs) ratio requires calculation of pulmonary artery and aortic luminal areas and integrals of the Doppler systolic velocity curves. To simplify the Doppler calculation of the Qp/Qs ratio, the square of the ratio of pulmonary to aortic l...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Cloez JL,Schmidt KG,Birk E,Silverman NH

    更新日期:1988-04-01 00:00:00

  • Mechanism of prevention of sudden death by nadolol: differential actions on arrhythmia triggers and substrate after myocardial infarction in the dog.

    abstract::Electrocardiographic monitoring and provocative ventricular pacing were used to evaluate control and nadolol treatment groups 6 to 24 hours after left anterior descending coronary artery ligation in the dog. During the 6 to 24 hour period, the control group (n = 20) developed ventricular triplets at rates exceeding 27...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Patterson E,Scherlag BJ,Lazzara R

    更新日期:1986-12-01 00:00:00

  • In vivo effects of nonionic and ionic contrast media on beta-thromboglobulin and fibrinopeptide levels.

    abstract::Nonionic contrast media are suggested to cause increased thromboembolism (in vivo), platelet aggregation and procoagulant effect (in vitro) as compared with ionic contrast media. To study these effects in vivo, 30 consecutive patients undergoing routine angiography were prospectively randomized to three groups of 10 p...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Arora R,Khandelwal M,Gopal A

    更新日期:1991-06-01 00:00:00

  • Ongoing clinical trials of angiotensin-converting enzyme inhibitors for treatment of coronary artery disease in patients with preserved left ventricular function.

    abstract::At present there is considerable activity in the area of prevention of atherosclerosis-related events using angiotensin-converting enzyme inhibitors. Large trials have demonstrated significant reduction in cardiovascular morbidity and mortality with long-term use of angiotensin-converting enzyme inhibitors in patients...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审


    authors: Pepine CJ

    更新日期:1996-04-01 00:00:00

  • Medical Therapy for Heart Failure With Reduced Ejection Fraction: The CHAMP-HF Registry.

    abstract:BACKGROUND:Guidelines strongly recommend patients with heart failure with reduced ejection fraction (HFrEF) be treated with multiple medications proven to improve clinical outcomes, as tolerated. The degree to which gaps in medication use and dosing persist in contemporary outpatient practice is unclear. OBJECTIVES:Th...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Greene SJ,Butler J,Albert NM,DeVore AD,Sharma PP,Duffy CI,Hill CL,McCague K,Mi X,Patterson JH,Spertus JA,Thomas L,Williams FB,Hernandez AF,Fonarow GC

    更新日期:2018-07-24 00:00:00

  • Geographic Variation in the Treatment of U.S. Adult Heart Transplant Candidates.

    abstract:BACKGROUND:The current U.S. priority ranking for heart candidates is based on treatment intensity, not objective markers of severity of illness. This system may encourage centers to overtreat candidates. OBJECTIVES:This study sought to describe national variation in the intensity of treatment of adult heart transplant...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Parker WF,Anderson AS,Hedeker D,Huang ES,Garrity ER Jr,Siegler M,Churpek MM

    更新日期:2018-04-24 00:00:00

  • Low molecular weight heparin (enoxaparin) reduces restenosis after iliac angioplasty in the hypercholesterolemic rabbit.

    abstract::Smooth muscle cell proliferation is central to the process of restenosis. Attempts to inhibit the events leading to this proliferation have met with little success. In addition to its known antithrombotic effects, heparin also has inhibitory effects on smooth muscle cell proliferation. These effects appear to be unrel...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Currier JW,Pow TK,Haudenschild CC,Minihan AC,Faxon DP

    更新日期:1991-05-01 00:00:00

  • Lack of association of C-reactive protein and coronary calcium by electron beam computed tomography in postmenopausal women: implications for coronary artery disease screening.

    abstract:OBJECTIVES:We sought to test the hypothesis that C-reactive protein, a marker of inflammation, would correlate positively with coronary calcium, a marker of atherosclerosis, in postmenopausal women. BACKGROUND:High sensitivity testing for C-reactive protein (hsCRP) has recently been shown in large population studies t...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Redberg RF,Rifai N,Gee L,Ridker PM

    更新日期:2000-07-01 00:00:00

  • Hematologic correlates of left atrial spontaneous echo contrast and thromboembolism in nonvalvular atrial fibrillation.

    abstract:OBJECTIVES:This study examined the relation between left atrial spontaneous echo contrast, hematologic variables and thrombo-embolism in patients with nonvalvular atrial fibrillation. BACKGROUND:Left atrial spontaneous echo contrast is associated with left atrial stasis and thromboembolism in patients with nonvalvular...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Black IW,Chesterman CN,Hopkins AP,Lee LC,Chong BH,Walsh WF

    更新日期:1993-02-01 00:00:00

  • Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines.

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    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,评论,杂志文章,随机对照试验


    authors: Bozkurt B,Agoston I,Knowlton AA

    更新日期:2003-01-15 00:00:00

  • Tachycardia, contractility and volume loading alter conventional indexes of coronary flow reserve, but not the instantaneous hyperemic flow versus pressure slope index.

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    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Cleary RM,Ayon D,Moore NB,DeBoe SF,Mancini GB

    更新日期:1992-11-01 00:00:00

  • Randomized comparison of upstream tirofiban versus downstream high bolus dose tirofiban or abciximab on tissue-level perfusion and troponin release in high-risk acute coronary syndromes treated with percutaneous coronary interventions: the EVEREST trial.

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    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Bolognese L,Falsini G,Liistro F,Angioli P,Ducci K,Taddei T,Tarducci R,Cosmi F,Baldassarre S,Burali A

    更新日期:2006-02-07 00:00:00

  • Survival of patients with diabetes and multivessel coronary artery disease after surgical or percutaneous coronary revascularization: results of a large regional prospective study. Northern New England Cardiovascular Disease Study Group.

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    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Niles NW,McGrath PD,Malenka D,Quinton H,Wennberg D,Shubrooks SJ,Tryzelaar JF,Clough R,Hearne MJ,Hernandez F Jr,Watkins MW,O'Connor GT,Northern New England Cardiovascular Disease Study Group.

    更新日期:2001-03-15 00:00:00