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Homocysteine hypothesis for atherothrombotic cardiovascular disease: not validated.

Abstract：

:Homocysteine has been implicated in promoting atherosclerotic and thrombotic vascular disease. During the last decade, the utility of homocysteine in predicting risk for atherothrombotic vascular disease has been evaluated in several observational studies in a large number of patients. These studies show that the overall risk for vascular disease is small, with prospective, longitudinal studies reporting a weaker association between homocysteine and atherothrombotic vascular disease compared to retrospective case-control and cross-sectional studies. Furthermore, randomized controlled trials of homocysteine-lowering therapy have failed to prove a causal relationship. On the basis of these results, there is currently insufficient evidence to recommend routine screening and treatment of elevated homocysteine concentrations with folic acid and other vitamins to prevent atherothrombotic vascular disease. This review outlines the metabolism and pathophysiology of homocysteine, highlights the results of homocysteine observational and interventional trials, and presents areas of uncertainty and potential future work.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Kaul S,Zadeh AA,Shah PK

doi

10.1016/j.jacc.2006.04.086

subject

Has Abstract

pub_date

2006-09-05 00:00:00

pages

914-23

issue

5

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(06)01466-5

journal_volume

48

pub_type

杂志文章,评审

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