Abstract：
:Directional coronary atherectomy, a new transluminal procedure for treatment of obstructive lesions in coronary arteries by excision and removal of tissue, was performed on 447 lesions in 382 procedures. Successful outcome, defined as a reduction of stenosis by greater than or equal to 20% with a less than 50% residual stenosis, was achieved in 89.5% of lesions and mean stenosis was reduced from 75.9 +/- 13.3% to 14.5 +/- 22.1% (p less than 0.001). Complications included vessel occlusion during the procedure, 2.4%; vessel occlusion after the procedure, 1.3%; new lesion, 0.5%; nonobstructive guiding catheter-induced dissection, 0.3%; perforation, 0.8%; distal embolization, 2.1%; Q wave myocardial infarction, 0.8% and non-Q wave myocardial infarction, 4.2%. Twelve patients (3.1%) required coronary artery bypass surgery for these complications. The atherectomy success rate was greater than 80% and the combined atherectomy and angioplasty success rate was greater than 90% for complex morphologic features such as eccentric lesions, lengthy lesions, lesions with abnormal contour, angulated lesions, ostial lesions and lesions with branch involvement. In the presence of calcific deposition, atherectomy success rate was 52% for primary lesions and 83% for restenosed lesions. Among angiographically complex lesions, calcium was the predictor for failed atherectomy (p less than 0.0001). In summary, directional coronary atherectomy is safe and effective for treatment of obstructive lesions in coronary arteries in selected cases. In particular, it achieves a high success rate in lesions with complex morphologic characteristics, such as eccentricity, abnormal contour and ostial involvement.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Hinohara T,Rowe MH,Robertson GC,Selmon MR,Braden L,Leggett JH,Vetter JW,Simpson JBdoi
10.1016/0735-1097(91)90840-6subject
Has Abstractpub_date
1991-04-01 00:00:00pages
1112-20issue
5eissn
0735-1097issn
1558-3597pii
0735-1097(91)90840-6journal_volume
17pub_type
杂志文章abstract：OBJECTIVE:The purpose of this study was to determine if the atrial response upon cessation of ventricular pacing associated with 1:1 ventriculoatrial conduction during paroxysmal supraventricular tachycardia is a useful diagnostic maneuver in the electrophysiology laboratory. BACKGROUND:Despite various maneuvers, it c...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(98)00614-7
更新日期：1999-03-01 00:00:00
abstract：:The purpose of this study was to investigate whether heart rate variability could be reliably assessed in patients with ventricular arrhythmias and to evaluate whether it is affected by antiarrhythmic drugs. The study was based on an analysis of 239 ambulatory electrocardiographic (ECG) recordings obtained from 67 pat...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(10)80172-x
更新日期：1991-03-01 00:00:00
abstract：:The highest-risk patients with heart failure with reduced ejection fraction are those with ischemic cardiomyopathy and severe left ventricular systolic dysfunction (ejection fraction≤35%). The cornerstone of treatment is guideline-driven medical therapy for all patients and implantable device therapy for appropriately...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2014.10.070
更新日期：2015-02-17 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the feasibility and safety of carotid artery stenting (CAS) with a filter protection system. BACKGROUND:Neurologic events linked to the embolization of particulate matter to the cerebral circulation may complicate CAS. Strategies designed to capture embolic particles du...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0735-1097(02)01692-3
更新日期：2002-03-06 00:00:00
abstract：BACKGROUND:The wearable cardioverter-defibrillator (WCD) has emerged as a means of protecting patients with newly diagnosed nonischemic cardiomyopathy (NICM) or ischemic cardiomyopathy (ICM) against sudden cardiac death while awaiting re-evaluation of cardiac function. OBJECTIVES:This study sought to characterize the ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2015.09.079
更新日期：2015-12-15 00:00:00
abstract：:Coronary artery calcium (CAC) is a highly specific feature of coronary atherosclerosis. On the basis of single-center and multicenter clinical and population-based studies with short-term and long-term outcomes data (up to 15-year follow-up), CAC scoring has emerged as a widely available, consistent, and reproducible ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2018.05.027
更新日期：2018-07-24 00:00:00
abstract：OBJECTIVES:We investigated whether three platelet gene polymorphisms, Pl(A1/A2), C807T, and C-5T Kozak (encoding, respectively, for platelet membrane glycoproteins (GP) IIIa, GP Ia/IIa, GP Ibalpha), could contribute to the resistance to a low dose of aspirin (160 mg/day). BACKGROUND:Aspirin antiplatelet effect is not ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(03)00921-5
更新日期：2003-09-17 00:00:00
abstract：:The mechanism of electrocardiographic ST segment changes during acute coronary occlusion was evaluated in 28 consecutive patients with single vessel coronary artery disease undergoing coronary angioplasty. Patients were continuously monitored with a six lead electrocardiogram. Twenty-three patients showed ST changes i...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(85)80250-3
更新日期：1985-07-01 00:00:00
abstract：OBJECTIVES:This study was designed to establish the direct vascular effects of apelin in vivo in man. BACKGROUND:Apelin is the endogenous ligand for the previously orphaned G-protein-coupled receptor, APJ. This novel pathway is widely expressed in the cardiovascular system and is emerging as an important mediator of c...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2008.06.013
更新日期：2008-09-09 00:00:00
abstract：:Percutaneous coronary intervention (PCI) has become a mainstay in the treatment of patients with coronary artery disease. Currently, more than one million coronary angioplasty and stent implantation procedures are performed annually. Although increasingly complex lesions and higher risk patients are being successfully...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2003.09.032
更新日期：2004-02-04 00:00:00
abstract：:High-risk plaques that are vulnerable to rupture demonstrate distinct morphological characteristics. They are differentiated from the lesions responsible for stable coronary artery disease by their large necrotic cores, thin-inflamed fibrous caps, and positive remodeling. Adiponectin is an adipocytokine that is reduce...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2010.11.011
更新日期：2011-02-15 00:00:00
abstract：OBJECTIVES:The aim of this research was to assess the efficacy of paclitaxel-eluting stents in chronic total coronary occlusions (CTO). BACKGROUND:Percutaneous coronary interventions for CTOs are characterized by a high target vessel failure rate. METHODS:In 48 consecutive patients, paclitaxel-eluting stents (Taxus, ...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jacc.2004.09.040
更新日期：2004-12-21 00:00:00
abstract：OBJECTIVES:Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels predict incident coronary heart disease (CHD) in adults without known CHD, independent of heart disease risk factors. We examined whether the independent association was apparent in older adults. BACKGROUND:Serum levels of Lp-PLA2, an enzyme that hydr...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2007.10.048
更新日期：2008-03-04 00:00:00
abstract：OBJECTIVES:We hypothesized that angiotensin-converting enzyme inhibition (ACE-I) during left ventricular assist device (LVAD) support in patients with end-stage heart failure prevents potentially deleterious effects on the extracellular matrix. BACKGROUND:Left ventricular assist device-induced mechanical unloading inc...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2006.10.071
更新日期：2007-03-20 00:00:00
abstract：:High-sensitivity cardiac troponin (hs-cTn) assays have been used clinically by thousands of physicians in many countries throughout the world since their clinical introduction 7 years ago. In the early diagnosis of myocardial infarction (MI), beyond doubt, the most important indication of hs-cTn assays, these simple, ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2017.07.718
更新日期：2017-08-22 00:00:00
abstract：OBJECTIVES:This study investigated the influences of ventricular morphology, hemodynamics and clinical findings on exercise capacity in patients after the Fontan operation. BACKGROUND:Determinants of exercise capacity after the Fontan operation remain unclear. METHODS:Peak oxygen uptake (PVo2) was determined in 105 p...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(01)01266-9
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVES:The effect of dipyridamole on smooth muscle cell proliferation and prevention of intimal thickening after arterial injury was investigated. BACKGROUND:In addition to antiplatelet activity, dipyridamole also inhibits cell proliferation. We examined whether the antiproliferative action of dipyridamole on smoo...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(94)90752-8
更新日期：1994-03-01 00:00:00
abstract：:Analysis of the rate-related change in exercise-induced ST segment depression using the exercise ST segment/heart rate slope and ST segment/heart rate index can improve the accuracy of the exercise electrocardiogram (ECG) for the identification of patients with coronary artery disease, recognition of patients with ana...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/0735-1097(95)00085-i
更新日期：1995-06-01 00:00:00
abstract：OBJECTIVES:This study compared the efficacy and safety of two antitachycardia pacing algorithms in the treatment of ventricular tachycardia. BACKGROUND:There is agreement that antitachycardia pacing should be adapted to tachycardia rate and be delivered in a burst, but the ideal pacing pattern is not well understood. ...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0735-1097(93)90318-u
更新日期：1993-05-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(96)00136-2
更新日期：1996-08-01 00:00:00
abstract：OBJECTIVES:This study was designed to investigate the mutual effects of chronic atrial dilation and electrical remodeling on the characteristics of atrial fibrillation (AF). BACKGROUND:Both electrical remodeling and atrial dilation promote the inducibility and perpetuation of AF. METHODS:In seven goats AF was induced...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2005.09.041
更新日期：2006-02-07 00:00:00
abstract：OBJECTIVES:To assess whether 15-(p-[iodine-123] iodophenyl)-3-(R,S) methylpentadecanoic acid (BMIPP) imaging can identify previous ischemic areas, BMIPP SPECT was performed in patients with acute chest pain to compare its findings with those of technetium-99m-tetrofosmin (tetrofosmin) SPECT and coronary angiography. B...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(01)01634-5
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVE:We sought to evaluate the vena contracta width (VCW) measured using color Doppler as an index of severity of tricuspid regurgitation (TR). BACKGROUND:The VCW is a reliable measure of mitral and aortic regurgitation, but its value in measuring TR is uncertain. METHODS:In 71 consecutive patients with TR, the ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(00)00762-2
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVES:In a substudy to a recently reported investigation that demonstrated the benefit of immunoglobulin adsorption (immunoadsorption) for patients with idiopathic dilated cardiomyopathy (IDC), we tested whether this benefit is associated with a reduction of oxidative stress. BACKGROUND:The progression of cardiom...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(01)01309-2
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVES:The goal of this study was to evaluate the role of percutaneous aortic valvuloplasty in patients with cardiogenic shock due to severe aortic stenosis and associated major comorbid conditions and to establish predictors of survival. BACKGROUND:The prognosis for patients in cardiogenic shock with severe aorti...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(94)90592-4
更新日期：1994-04-01 00:00:00
abstract：OBJECTIVES:The aim of this randomized placebo-controlled trial was to determine if withdrawing clopidogrel therapy leads to increased platelet activity compared with pre-treatment values in patients with stable coronary artery or peripheral arterial disease. BACKGROUND:Reports of increased cardiovascular events after ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jacc.2013.10.018
更新日期：2014-01-28 00:00:00
abstract：:The management of anticoagulant therapy in patients with atrial fibrillation undergoing electrical cardioversion remains controversial, largely because of inadequate studies demonstrating risk or benefit, a relatively inconvenient anticoagulation management strategy and the increasing use of transesophageal echocardio...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/0735-1097(94)90443-x
更新日期：1994-02-01 00:00:00
abstract：:The feasibility of using a flexible, steerable angioscope to perform coronary angioscopy before and after percutaneous coronary angioplasty was tested. The microangioscope fits through an 8F coronary angioplasty guiding catheter and contains a multifiber viewing bundle incorporated into the body of a 4.3F balloon cath...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章
doi：10.1016/0735-1097(91)90710-q
更新日期：1991-01-01 00:00:00
abstract：:Many patients with hypertrophic cardiomyopathy experience postprandial exacerbation of their symptoms. The vasodilation associated with eating may be deleterious in hypertrophic cardiomyopathy, especially during exercise. To examine the hemodynamic effects of a meal in hypertrophic cardiomyopathy, 11 patients were stu...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(91)90596-2
更新日期：1991-08-01 00:00:00
abstract：:Evidence from cohort studies and a randomized clinical trial indicates that annual vaccination against seasonal influenza prevents cardiovascular morbidity and all-cause mortality in patients with cardiovascular conditions. The American Heart Association and American College of Cardiology recommend influenza immunizat...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,实务指引,评审
doi：10.1016/j.jacc.2006.09.004
更新日期：2006-10-03 00:00:00
