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Decreased oxidative stress in patients with idiopathic dilated cardiomyopathy one year after immunoglobulin adsorption.

Abstract：

OBJECTIVES:In a substudy to a recently reported investigation that demonstrated the benefit of immunoglobulin adsorption (immunoadsorption) for patients with idiopathic dilated cardiomyopathy (IDC), we tested whether this benefit is associated with a reduction of oxidative stress. BACKGROUND:The progression of cardiomyopathy is believed to be related to the increase of oxidative stress. Therefore, reduction of oxidative stress could be one of the effects of immunoadsorption for improvement of cardiac performance and clinical status. METHODS:Plasma markers for oxidative stress-thiobarbituric acid-reactive substances (TBARS), lipid peroxides (LPO), anti-oxidized low-density lipoprotein-autoantibodies (anti-oxLDL-AB), thiol groups and vitamin E-were compared in 31 patients, of whom 16 underwent immunoadsorption and 15 received conventional treatment (controls). All patients received a daily supplement of vitamins, minerals and trace elements. RESULTS:After one year, TBARS (p = 0.026), LPO (p = 0.026) and anti-oxLD

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Schimke I,Müller J,Priem F,Kruse I,Schön B,Stein J,Kunze R,Wallukat G,Hetzer R

doi

10.1016/s0735-1097(01)01309-2

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

178-83

issue

1

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(01)01309-2

journal_volume

38

pub_type

杂志文章

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