Abstract:
OBJECTIVES:The purpose of this study was to compare 3 non-invasive techniques for assessment of endothelial function in adults and children and evaluate their utility in acute inflammation. BACKGROUND:Endothelial dysfunction is a key early event in pre-clinical atherosclerosis. Flow-mediated dilation (FMD), although the established technique, is expensive and technically demanding. Measurements of vascular responses to inhaled salbutamol by pulse wave analysis (PWA) or pulse contour analysis (PCA) are potential alternatives. METHODS:Sixteen adults (mean age 28 years, range 18 to 39) and 16 children (mean age 13 years, range 7 to 17) underwent concurrent vascular function testing on 2 occasions with ultrasound, PWA, and PCA. Eighteen men were also studied before and after typhoid vaccination. RESULTS:Reproducibility of FMD was high in adults and children (coefficient of variation [CV] = 7.1 and 6.3, respectively). Salbutamol responses were more variable with PWA (adults CV = 11.5, children CV = 17.1) and PCA particularly in children (adults CV = 18.2, children CV = 36.3). Flow-mediated dilation (p < 0.001) and PWA with salbutamol (p = 0.03) responses fell after typhoid vaccination, and PCA (p = 0.7) was unchanged. CONCLUSIONS:Vascular dysfunction during acute inflammation can be measured by FMD and by PWA with salbutamol. Flow-mediated dilation is less variable than PWA. Variability of PCA makes this technique currently unsuited to serial measures of endothelial function in children. Flow-mediated dilation remains the most reproducible method.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Donald AE,Charakida M,Cole TJ,Friberg P,Chowienczyk PJ,Millasseau SC,Deanfield JE,Halcox JPdoi
10.1016/j.jacc.2006.07.039subject
Has Abstractpub_date
2006-11-07 00:00:00pages
1846-50issue
9eissn
0735-1097issn
1558-3597pii
S0735-1097(06)01967-Xjournal_volume
48pub_type
杂志文章abstract:BACKGROUND:Major disparities between women and men in the diagnosis, management, and outcomes of acute coronary syndrome are well recognized. OBJECTIVES:The aim of this study was to evaluate the impact of implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds for myocardial in...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jacc.2019.07.082
更新日期:2019-10-22 00:00:00
abstract:OBJECTIVES:The purpose of this study was to validate a digital color Doppler (DCD) automated cardiac flow measurement method for quantifying pulmonary regurgitation (PR) in an in vitro and a chronic animal model of the right ventricular outflow tract of postoperative tetralogy of Fallot (TOF). BACKGROUND:There has bee...
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doi:10.1016/s0735-1097(00)01106-2
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abstract::The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Trial randomized 368 patients with symptoms and signs of acute myocardial infarction of less than 6 h duration to either conventional care or 1.5 million units of intravenous streptokinase. The mean time to randomization was 209 min and 52...
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pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0735-1097(88)90197-0
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVES:This study tested whether genetic variation in the CETP gene is consistent with a protective effect of cholesteryl ester transfer protein (CETP) inhibition on risk of ischemic events and on total mortality, without the adverse effects reported for torcetrapib. BACKGROUND:Torcetrapib, an inhibitor of CETP, i...
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更新日期:2012-11-13 00:00:00
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doi:10.1016/s0735-1097(98)00221-6
更新日期:1998-07-01 00:00:00
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doi:10.1016/j.jacc.2013.07.091
更新日期:2014-01-28 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(98)00283-6
更新日期:1998-09-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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journal_title:Journal of the American College of Cardiology
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更新日期:2012-12-18 00:00:00
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更新日期:2009-03-17 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2008-09-16 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-07-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2005-12-06 00:00:00
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更新日期:2012-06-19 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1989-08-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 评论,杂志文章
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更新日期:2007-05-08 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(10)80156-1
更新日期:1991-05-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2008.01.028
更新日期:2008-04-29 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2010-02-16 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1994-06-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2003.12.054
更新日期:2004-06-02 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
abstract:OBJECTIVES:This study was designed to evaluate the presence or absence of atypical T wave evolution in patients with a postinfarction pericardial effusion but without clinically recognized postinfarction pericarditis. A second purpose was to evaluate the frequency of atypical T wave evolution in a previous study of pos...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
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更新日期:1994-10-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1996-11-15 00:00:00