Abstract:
OBJECTIVES:To determine the effect of angiotensin-converting enzyme (ACE) inhibition on brachial flow-mediated vasodilation. BACKGROUND:Quinapril, an ACE inhibitor with high affinity, has been shown to improve coronary endothelial dysfunction in patients with coronary artery disease. The effectiveness of different vasoactive agents to improve human endothelial function is unknown. METHODS:High resolution ultrasound was used to assess endothelium-dependent brachial artery flow-mediated vasodilation (FMD) in patients with coronary disease. We studied 80 patients (mean age 58 +/- 0.9 years) in a partial-block, cross-over design trial. Patients were randomized to one of four different drug sequences to receive quinapril 20 mg, enalapril 10 mg, losartan 50 mg or amlodipine 5 mg daily. Each patient received three drugs with a two-week washout period between treatments. The primary end point was the absolute difference in FMD after eight weeks of each study drug compared with their respective baselines analyzed in a blinded fashion. RESULTS:There was mild impairment of FMD at baseline (7.3 +/- 0.6%). The change in FMD from baseline was significant only for quinapril (1.8 +/- 1%, p < 0.02). No change was seen with losartan (0.8 +/- 1.1%, p = 0.57), amlodipine (0.3 +/- 0.9%, p = 0.97) or enalapril (-0.2 +/- 0.8%, p = 0.84). No significant change in nitroglycerin-induced dilation occurred with drug therapy. The improvement in quinapril response was not seen in those with the DD ACE genotype (0.5 +/- 2.1%) but was seen in those with the ID and II genotype (3.3 +/- 1.2 and 3.2 +/- 1.9%, respectively, p = 0.03). CONCLUSION:Only quinapril was associated with significant improvement in FMD, and this response is related to the presence of the insertion allele of the ACE genotype.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Anderson TJ,Elstein E,Haber H,Charbonneau Fdoi
10.1016/s0735-1097(99)00537-9subject
Has Abstractpub_date
2000-01-01 00:00:00pages
60-6issue
1eissn
0735-1097issn
1558-3597pii
S0735-1097(99)00537-9journal_volume
35pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVES:This study attempted to evaluate the effects of supine and lateral recumbent positions on pulmonary venous flow by transesophageal Doppler echocardiography in healthy subjects. BACKGROUND:Although transesophageal echocardiographic examination is usually performed with the patient lying in the left lateral d...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(94)90154-6
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abstract:OBJECTIVES:The Air Primary Angioplasty in Myocardial Infarction (PAMI) study was designed to determine the best reperfusion strategy for patients with high-risk acute myocardial infarction (AMI) at hospitals without percutaneous transluminal coronary angioplasty (PTCA) capability. BACKGROUND:Previous studies have sugg...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0735-1097(02)01870-3
更新日期:2002-06-05 00:00:00
abstract:BACKGROUND:Previously, observational studies have identified associations between higher levels of dietary-derived antioxidants and lower risk of coronary heart disease (CHD), whereas randomized clinical trials showed no reduction in CHD risk following antioxidant supplementation. OBJECTIVES:The purpose of this study ...
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doi:10.1016/j.jacc.2020.10.048
更新日期:2021-01-05 00:00:00
abstract::Thirty-one dogs underwent in vivo scanning with computed transmission tomography; 15 dogs were studied within 7 days (mean 4) after coronary occlusion, 10 dogs 21 to 25 days (mean 28) after occlusion and 6 dogs 4 days after coronary reperfusion of a 2 to 3 hour coronary ligation. Ungated scans (1 cm in depth) of the l...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,收录出版
doi:10.1016/s0735-1097(84)80440-4
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the efficacy of radiofrequency catheter ablation (RFCA) in the treatment of hypertrophic obstructive cardiomyopathy in children. BACKGROUND:Hypertrophic obstructive cardiomyopathy is an uncommon cause of left ventricular outflow tract obstruction in children. In symptomat...
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更新日期:2011-12-06 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2011-11-22 00:00:00
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doi:10.1016/j.jacc.2005.11.083
更新日期:2006-05-16 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(98)00005-9
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journal_title:Journal of the American College of Cardiology
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更新日期:1984-06-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:2000-05-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2003-05-07 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(85)80264-3
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doi:10.1016/s0735-1097(10)80351-1
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of the American College of Cardiology
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journal_title:Journal of the American College of Cardiology
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更新日期:2013-04-09 00:00:00
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更新日期:2003-06-18 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2002-08-21 00:00:00
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更新日期:2009-12-01 00:00:00
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更新日期:2010-05-04 00:00:00
abstract:OBJECTIVES:The purpose of this study was to characterize the occurrence of phrenic nerve injury (PNI) and its outcome after radiofrequency (RF) ablation of atrial fibrillation (AF). BACKGROUND:It is recognized that extra-myocardial damage may develop owing to penetration of ablative energy. METHODS:Between 1997 and 2...
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更新日期:2006-06-20 00:00:00
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更新日期:2020-03-17 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1994-04-01 00:00:00